Structural basis for shape-selective recognition and aminoacylation of a D-armless human mitochondrial tRNA
Mitochondrial tRNAs are indispensable and yet underwent an extreme mutational erosion. The authors report the structures of a mitochondrial aaRS-tRNA complex and show how the most degenerated of all human mtRNAs is recognized by its cognate synthetase to maintain mitochondrial gene expression.
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-32544-1 |
| _version_ | 1811274842516750336 |
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| author | Bernhard Kuhle Marscha Hirschi Lili K. Doerfel Gabriel C. Lander Paul Schimmel |
| author_facet | Bernhard Kuhle Marscha Hirschi Lili K. Doerfel Gabriel C. Lander Paul Schimmel |
| author_sort | Bernhard Kuhle |
| collection | DOAJ |
| description | Mitochondrial tRNAs are indispensable and yet underwent an extreme mutational erosion. The authors report the structures of a mitochondrial aaRS-tRNA complex and show how the most degenerated of all human mtRNAs is recognized by its cognate synthetase to maintain mitochondrial gene expression. |
| first_indexed | 2024-04-12T23:27:26Z |
| format | Article |
| id | doaj.art-c61de2c5906644379fa90b8007176bd0 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T23:27:26Z |
| publishDate | 2022-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-c61de2c5906644379fa90b8007176bd02022-12-22T03:12:23ZengNature PortfolioNature Communications2041-17232022-08-0113111210.1038/s41467-022-32544-1Structural basis for shape-selective recognition and aminoacylation of a D-armless human mitochondrial tRNABernhard Kuhle0Marscha Hirschi1Lili K. Doerfel2Gabriel C. Lander3Paul Schimmel4Department of Molecular Medicine, The Scripps Research InstituteDepartment of Integrative Structural and Computational Biology, The Scripps Research InstituteDepartment of Integrative Structural and Computational Biology, The Scripps Research InstituteDepartment of Integrative Structural and Computational Biology, The Scripps Research InstituteDepartment of Molecular Medicine, The Scripps Research InstituteMitochondrial tRNAs are indispensable and yet underwent an extreme mutational erosion. The authors report the structures of a mitochondrial aaRS-tRNA complex and show how the most degenerated of all human mtRNAs is recognized by its cognate synthetase to maintain mitochondrial gene expression.https://doi.org/10.1038/s41467-022-32544-1 |
| spellingShingle | Bernhard Kuhle Marscha Hirschi Lili K. Doerfel Gabriel C. Lander Paul Schimmel Structural basis for shape-selective recognition and aminoacylation of a D-armless human mitochondrial tRNA Nature Communications |
| title | Structural basis for shape-selective recognition and aminoacylation of a D-armless human mitochondrial tRNA |
| title_full | Structural basis for shape-selective recognition and aminoacylation of a D-armless human mitochondrial tRNA |
| title_fullStr | Structural basis for shape-selective recognition and aminoacylation of a D-armless human mitochondrial tRNA |
| title_full_unstemmed | Structural basis for shape-selective recognition and aminoacylation of a D-armless human mitochondrial tRNA |
| title_short | Structural basis for shape-selective recognition and aminoacylation of a D-armless human mitochondrial tRNA |
| title_sort | structural basis for shape selective recognition and aminoacylation of a d armless human mitochondrial trna |
| url | https://doi.org/10.1038/s41467-022-32544-1 |
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