Altered ocular microvasculature in patients with systemic sclerosis and very early disease of systemic sclerosis using optical coherence tomography angiography
Abstract The vascular hypothesis of systemic sclerosis (SSc) would predict microvascular alterations should also affect anatomical regions like ocular microvasculature. The objective of this study was to evaluate retinal and choriocapillary vessel density (VD) in patients with definite SSc and very...
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Nature Portfolio
2022-06-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-14377-6 |
| _version_ | 1811328800647020544 |
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| author | Nataša Mihailovic Larissa Lahme Sonja Braasch Friederike Rosenberger Nicole Eter Jan Ehrchen Maged Alnawaiseh |
| author_facet | Nataša Mihailovic Larissa Lahme Sonja Braasch Friederike Rosenberger Nicole Eter Jan Ehrchen Maged Alnawaiseh |
| author_sort | Nataša Mihailovic |
| collection | DOAJ |
| description | Abstract The vascular hypothesis of systemic sclerosis (SSc) would predict microvascular alterations should also affect anatomical regions like ocular microvasculature. The objective of this study was to evaluate retinal and choriocapillary vessel density (VD) in patients with definite SSc and very early disease of systemic sclerosis (VEDOSS) using optical coherence tomography angiography (OCTA). 22 eyes of 22 patients and 22 eyes of 22 healthy subjects were included in this study. Patients were classified into patients with definite SSc and patients with VEDOSS. VD data of the superficial OCT angiogram (OCTA-SCP), deep OCT angiogram (OCTA-DCP) and choriocapillaris (OCTA-CC) were analysed. VD in the OCTA-SCP and OCTA-CC was lower in patients with SSc (p < 0.05). In VEDOSS patients, VD in the OCTA-CC was still reduced compared to controls (p < 0.05). Correlation analysis revealed a positive correlation between nailfold capillaroscopy and VD of OCTA-CC (Spearman correlation coefficient (rSp) 0.456, p < 0.05) and a negative correlation between skin score and VD of OCTA-SCP (p < 0.05). Ocular perfusion seems to be impaired in patients with SSc and even VEDOSS. VD correlated with disease severity. OCTA could be a new useful diagnostic and predictive parameter for monitoring patients with different stages of the disease. |
| first_indexed | 2024-04-13T15:32:35Z |
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| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-13T15:32:35Z |
| publishDate | 2022-06-01 |
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| series | Scientific Reports |
| spelling | doaj.art-c61e3fb78db048c5af8165c0623756792022-12-22T02:41:21ZengNature PortfolioScientific Reports2045-23222022-06-011211710.1038/s41598-022-14377-6Altered ocular microvasculature in patients with systemic sclerosis and very early disease of systemic sclerosis using optical coherence tomography angiographyNataša Mihailovic0Larissa Lahme1Sonja Braasch2Friederike Rosenberger3Nicole Eter4Jan Ehrchen5Maged Alnawaiseh6Department of Ophthalmology, University of Muenster Medical CenterDepartment of Ophthalmology, University of Muenster Medical CenterDepartment of Dermatology, University of MuensterDepartment of Ophthalmology, University of Muenster Medical CenterDepartment of Ophthalmology, University of Muenster Medical CenterDepartment of Dermatology, University of MuensterDepartment of Ophthalmology, University of Muenster Medical CenterAbstract The vascular hypothesis of systemic sclerosis (SSc) would predict microvascular alterations should also affect anatomical regions like ocular microvasculature. The objective of this study was to evaluate retinal and choriocapillary vessel density (VD) in patients with definite SSc and very early disease of systemic sclerosis (VEDOSS) using optical coherence tomography angiography (OCTA). 22 eyes of 22 patients and 22 eyes of 22 healthy subjects were included in this study. Patients were classified into patients with definite SSc and patients with VEDOSS. VD data of the superficial OCT angiogram (OCTA-SCP), deep OCT angiogram (OCTA-DCP) and choriocapillaris (OCTA-CC) were analysed. VD in the OCTA-SCP and OCTA-CC was lower in patients with SSc (p < 0.05). In VEDOSS patients, VD in the OCTA-CC was still reduced compared to controls (p < 0.05). Correlation analysis revealed a positive correlation between nailfold capillaroscopy and VD of OCTA-CC (Spearman correlation coefficient (rSp) 0.456, p < 0.05) and a negative correlation between skin score and VD of OCTA-SCP (p < 0.05). Ocular perfusion seems to be impaired in patients with SSc and even VEDOSS. VD correlated with disease severity. OCTA could be a new useful diagnostic and predictive parameter for monitoring patients with different stages of the disease.https://doi.org/10.1038/s41598-022-14377-6 |
| spellingShingle | Nataša Mihailovic Larissa Lahme Sonja Braasch Friederike Rosenberger Nicole Eter Jan Ehrchen Maged Alnawaiseh Altered ocular microvasculature in patients with systemic sclerosis and very early disease of systemic sclerosis using optical coherence tomography angiography Scientific Reports |
| title | Altered ocular microvasculature in patients with systemic sclerosis and very early disease of systemic sclerosis using optical coherence tomography angiography |
| title_full | Altered ocular microvasculature in patients with systemic sclerosis and very early disease of systemic sclerosis using optical coherence tomography angiography |
| title_fullStr | Altered ocular microvasculature in patients with systemic sclerosis and very early disease of systemic sclerosis using optical coherence tomography angiography |
| title_full_unstemmed | Altered ocular microvasculature in patients with systemic sclerosis and very early disease of systemic sclerosis using optical coherence tomography angiography |
| title_short | Altered ocular microvasculature in patients with systemic sclerosis and very early disease of systemic sclerosis using optical coherence tomography angiography |
| title_sort | altered ocular microvasculature in patients with systemic sclerosis and very early disease of systemic sclerosis using optical coherence tomography angiography |
| url | https://doi.org/10.1038/s41598-022-14377-6 |
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