SAMe, Choline, and Valproic Acid as Possible Epigenetic Drugs: Their Effects in Pregnancy with a Special Emphasis on Animal Studies

SAMe, Choline, and Valproic Acid as Possible Epigenetic Drugs: Their Effects in Pregnancy with a Special Emphasis on Animal Studies

In this review, we discuss the functions and main effects on pregnancy outcomes of three agents that have the ability to induce epigenetic modifications: valproic acid (VPA), a well-known teratogen that is a histone deacetylase inhibitor; S-adenosylmethionine (SAMe), the most effective methyl donor;...

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Bibliographic Details
Main Authors: Asher Ornoy, Liza Weinstein-Fudim, Maria Becker
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Pharmaceuticals
Subjects:
S-adenosylmethionine (SAMe)
valproic acid (VPA)
choline
epigenetic modulators
gene expression
gestation
Online Access:https://www.mdpi.com/1424-8247/15/2/192

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