The Potential Role of Small-Molecule PERK Inhibitor LDN-0060609 in Primary Open-Angle Glaucoma Treatment

The Potential Role of Small-Molecule PERK Inhibitor LDN-0060609 in Primary Open-Angle Glaucoma Treatment

Primary open-angle glaucoma (POAG) constitutes the most common type of glaucoma. Emerging evidence suggests that Endoplasmic Reticulum (ER) stress and the protein kinase RNA-like endoplasmic reticulum kinase (PERK)-mediated Unfolded Protein Response (UPR) signaling pathway play a key role in POAG pa...

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Bibliographic Details
Main Authors: Wioletta Rozpędek-Kamińska, Grzegorz Galita, Natalia Siwecka, Steven L. Carroll, John Alan Diehl, Ewa Kucharska, Dariusz Pytel, Ireneusz Majsterek
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
glaucoma
PERK
eIF2α
endoplasmic reticulum stress
unfolded protein response
apoptosis
Online Access:https://www.mdpi.com/1422-0067/22/9/4494

Internet

https://www.mdpi.com/1422-0067/22/9/4494

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