Electrically stimulated cell migration and its contribution to wound healing
Abstract Naturally occurring electric fields are known to be morphogenetic cues and associated with growth and healing throughout mammalian and amphibian animals and the plant kingdom. Electricity in animals was discovered in the eighteenth century. Electric fields activate multiple cellular signali...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Oxford University Press
2018-07-01
|
| Series: | Burns & Trauma |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s41038-018-0123-2 |
| _version_ | 1819078407461273600 |
|---|---|
| author | Guangping Tai Michael Tai Min Zhao |
| author_facet | Guangping Tai Michael Tai Min Zhao |
| author_sort | Guangping Tai |
| collection | DOAJ |
| description | Abstract Naturally occurring electric fields are known to be morphogenetic cues and associated with growth and healing throughout mammalian and amphibian animals and the plant kingdom. Electricity in animals was discovered in the eighteenth century. Electric fields activate multiple cellular signaling pathways such as PI3K/PTEN, the membrane channel of KCNJ15/Kir4.2 and intracellular polyamines. These pathways are involved in the sensing of physiological electric fields, directional cell migration (galvanotaxis, also known as electrotaxis), and possibly other cellular responses. Importantly, electric fields provide a dominant and over-riding signal that directs cell migration. Electrical stimulation could be a promising therapeutic method in promoting wound healing and activating regeneration of chronic and non-healing wounds. This review provides an update of the physiological role of electric fields, its cellular and molecular mechanisms, its potential therapeutic value, and questions that still await answers. |
| first_indexed | 2024-12-21T19:12:36Z |
| format | Article |
| id | doaj.art-c62591a5c02b4e648a40713287c1233e |
| institution | Directory Open Access Journal |
| issn | 2321-3876 |
| language | English |
| last_indexed | 2024-12-21T19:12:36Z |
| publishDate | 2018-07-01 |
| publisher | Oxford University Press |
| record_format | Article |
| series | Burns & Trauma |
| spelling | doaj.art-c62591a5c02b4e648a40713287c1233e2022-12-21T18:53:09ZengOxford University PressBurns & Trauma2321-38762018-07-01611710.1186/s41038-018-0123-2Electrically stimulated cell migration and its contribution to wound healingGuangping Tai0Michael Tai1Min Zhao2Centre of Advanced Biofabrication, Department of Bioengineering and Environmental Sciences, Hefei UniversitySt Catherine’s College, Medical Sciences Division, University of OxfordDepartments of Dermatology and Ophthalmology, School of Medicine, University of CaliforniaAbstract Naturally occurring electric fields are known to be morphogenetic cues and associated with growth and healing throughout mammalian and amphibian animals and the plant kingdom. Electricity in animals was discovered in the eighteenth century. Electric fields activate multiple cellular signaling pathways such as PI3K/PTEN, the membrane channel of KCNJ15/Kir4.2 and intracellular polyamines. These pathways are involved in the sensing of physiological electric fields, directional cell migration (galvanotaxis, also known as electrotaxis), and possibly other cellular responses. Importantly, electric fields provide a dominant and over-riding signal that directs cell migration. Electrical stimulation could be a promising therapeutic method in promoting wound healing and activating regeneration of chronic and non-healing wounds. This review provides an update of the physiological role of electric fields, its cellular and molecular mechanisms, its potential therapeutic value, and questions that still await answers.http://link.springer.com/article/10.1186/s41038-018-0123-2Wound healingIon transportEndogenous electric fieldsElectrical stimulationCell migrationClinical trials |
| spellingShingle | Guangping Tai Michael Tai Min Zhao Electrically stimulated cell migration and its contribution to wound healing Burns & Trauma Wound healing Ion transport Endogenous electric fields Electrical stimulation Cell migration Clinical trials |
| title | Electrically stimulated cell migration and its contribution to wound healing |
| title_full | Electrically stimulated cell migration and its contribution to wound healing |
| title_fullStr | Electrically stimulated cell migration and its contribution to wound healing |
| title_full_unstemmed | Electrically stimulated cell migration and its contribution to wound healing |
| title_short | Electrically stimulated cell migration and its contribution to wound healing |
| title_sort | electrically stimulated cell migration and its contribution to wound healing |
| topic | Wound healing Ion transport Endogenous electric fields Electrical stimulation Cell migration Clinical trials |
| url | http://link.springer.com/article/10.1186/s41038-018-0123-2 |
| work_keys_str_mv | AT guangpingtai electricallystimulatedcellmigrationanditscontributiontowoundhealing AT michaeltai electricallystimulatedcellmigrationanditscontributiontowoundhealing AT minzhao electricallystimulatedcellmigrationanditscontributiontowoundhealing |