Synthesis, Characterization, Molecular Docking and Cytotoxicity Studies of Bagasse Xylem Ferulate-Acrylamide/Methyl Methacrylate Composite
BXFL (bagasse xylem ferulate)-g-AM (acrylamide)/MAA (methyl methacrylate) was synthesized based on bagasse xylan(BX)-g-AM/MAA in 1-Butyl-3-methylimidazolium chloride ([Bmim] Cl) ion solution with Ferulic Acid (FL) as esterification agent. The various factors that were investigated influenced carboxy...
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| Format: | Article |
| Language: | English |
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Iranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECR
2019-06-01
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| Series: | Iranian Journal of Chemistry & Chemical Engineering |
| Subjects: | |
| Online Access: | http://www.ijcce.ac.ir/article_34238_cc5f52b2c134d1afc1eb4d44d8163209.pdf |
| _version_ | 1811282103837392896 |
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| author | Kai Zuo Jingxia Qian Jun Gong Jun Zhang Heping Li Guoyong Zhou |
| author_facet | Kai Zuo Jingxia Qian Jun Gong Jun Zhang Heping Li Guoyong Zhou |
| author_sort | Kai Zuo |
| collection | DOAJ |
| description | BXFL (bagasse xylem ferulate)-g-AM (acrylamide)/MAA (methyl methacrylate) was synthesized based on bagasse xylan(BX)-g-AM/MAA in 1-Butyl-3-methylimidazolium chloride ([Bmim] Cl) ion solution with Ferulic Acid (FL) as esterification agent. The various factors that were investigated influenced carboxylic acid ester substitution degree (DSC) of BXFL-g-AM/MAA. The structures of BXFL-g-AM/MAA were confirmed by IR, SEM and 1H NMR analysis. The cytotoxicity of BXFL-g-AM/MAA was investigated against twelve kinds of protein through Surflex-Dock Mode of Sybyl-X 2.0 software, and on three kinds of human cancer cells line and the human normal cells line were detected by MTT assay. It was shown that the maximum DSC was 1.09 in ion solution, which was superior to DSC of conventional method in organic solvent. The results of MTT assay were consistent with docking results. BXFL-g-AM/MAA exhibited relative high cytotoxicity against human gastric cancer cells (MGC-803) line. |
| first_indexed | 2024-04-13T01:45:40Z |
| format | Article |
| id | doaj.art-c6284ef9499d48c5a8a3f1cf2bede86d |
| institution | Directory Open Access Journal |
| issn | 1021-9986 1021-9986 |
| language | English |
| last_indexed | 2024-04-13T01:45:40Z |
| publishDate | 2019-06-01 |
| publisher | Iranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECR |
| record_format | Article |
| series | Iranian Journal of Chemistry & Chemical Engineering |
| spelling | doaj.art-c6284ef9499d48c5a8a3f1cf2bede86d2022-12-22T03:08:03ZengIranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECRIranian Journal of Chemistry & Chemical Engineering1021-99861021-99862019-06-0138310711634238Synthesis, Characterization, Molecular Docking and Cytotoxicity Studies of Bagasse Xylem Ferulate-Acrylamide/Methyl Methacrylate CompositeKai Zuo0Jingxia Qian1Jun Gong2Jun Zhang3Heping Li4Guoyong Zhou5College of Chemistry and Bioengineering, Guilin University of Technology, Guilin 541006, Guangxi, P.R. CHINACollege of Chemistry and Bioengineering, Guilin University of Technology, Guilin 541006, Guangxi, P.R. CHINACollege of Chemistry and Bioengineering, Guilin University of Technology, Guilin 541006, Guangxi, P.R. CHINACollege of Chemistry and Bioengineering, Guilin University of Technology, Guilin 541006, Guangxi, P.R. CHINACollege of Chemistry and Bioengineering, Guilin University of Technology, Guilin 541006, Guangxi, P.R. CHINASchool of Chemistry and Eco-Environmental Engineering (School of Chinese Pharmacy), Guizhou Minzu University, Guiyang 550025, Guizhou, P.R. CHINABXFL (bagasse xylem ferulate)-g-AM (acrylamide)/MAA (methyl methacrylate) was synthesized based on bagasse xylan(BX)-g-AM/MAA in 1-Butyl-3-methylimidazolium chloride ([Bmim] Cl) ion solution with Ferulic Acid (FL) as esterification agent. The various factors that were investigated influenced carboxylic acid ester substitution degree (DSC) of BXFL-g-AM/MAA. The structures of BXFL-g-AM/MAA were confirmed by IR, SEM and 1H NMR analysis. The cytotoxicity of BXFL-g-AM/MAA was investigated against twelve kinds of protein through Surflex-Dock Mode of Sybyl-X 2.0 software, and on three kinds of human cancer cells line and the human normal cells line were detected by MTT assay. It was shown that the maximum DSC was 1.09 in ion solution, which was superior to DSC of conventional method in organic solvent. The results of MTT assay were consistent with docking results. BXFL-g-AM/MAA exhibited relative high cytotoxicity against human gastric cancer cells (MGC-803) line.http://www.ijcce.ac.ir/article_34238_cc5f52b2c134d1afc1eb4d44d8163209.pdfbagasse xylem ferulate-acrylamide/methyl methacrylatesynthesischaracterizationcytotoxicitymolecular docking |
| spellingShingle | Kai Zuo Jingxia Qian Jun Gong Jun Zhang Heping Li Guoyong Zhou Synthesis, Characterization, Molecular Docking and Cytotoxicity Studies of Bagasse Xylem Ferulate-Acrylamide/Methyl Methacrylate Composite Iranian Journal of Chemistry & Chemical Engineering bagasse xylem ferulate-acrylamide/methyl methacrylate synthesis characterization cytotoxicity molecular docking |
| title | Synthesis, Characterization, Molecular Docking and Cytotoxicity Studies of Bagasse Xylem Ferulate-Acrylamide/Methyl Methacrylate Composite |
| title_full | Synthesis, Characterization, Molecular Docking and Cytotoxicity Studies of Bagasse Xylem Ferulate-Acrylamide/Methyl Methacrylate Composite |
| title_fullStr | Synthesis, Characterization, Molecular Docking and Cytotoxicity Studies of Bagasse Xylem Ferulate-Acrylamide/Methyl Methacrylate Composite |
| title_full_unstemmed | Synthesis, Characterization, Molecular Docking and Cytotoxicity Studies of Bagasse Xylem Ferulate-Acrylamide/Methyl Methacrylate Composite |
| title_short | Synthesis, Characterization, Molecular Docking and Cytotoxicity Studies of Bagasse Xylem Ferulate-Acrylamide/Methyl Methacrylate Composite |
| title_sort | synthesis characterization molecular docking and cytotoxicity studies of bagasse xylem ferulate acrylamide methyl methacrylate composite |
| topic | bagasse xylem ferulate-acrylamide/methyl methacrylate synthesis characterization cytotoxicity molecular docking |
| url | http://www.ijcce.ac.ir/article_34238_cc5f52b2c134d1afc1eb4d44d8163209.pdf |
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