Rationale use of Thalidomide in erythema nodosum leprosum - A non-systematic critical analysis of published case reports
Abstract INTRODUCTION: Thalidomide is an anti- tumor necrosis factor alpha (TNF-a) drug used mainly in the management of moderate to severe form of Erythema Nodosum Leprosum (ENL). Because of its teratogenic potential it has to be used under proper supervision. Our critical analysis tries to look...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Medicina Tropical (SBMT)
2020-09-01
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| Series: | Revista da Sociedade Brasileira de Medicina Tropical |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822020000100333&tlng=en |
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| author | Pugazhenthan Thangaraju Sajitha Venkatesan Meenalotchini Gurunthalingam Shoban Babu Tamilselvan T |
| author_facet | Pugazhenthan Thangaraju Sajitha Venkatesan Meenalotchini Gurunthalingam Shoban Babu Tamilselvan T |
| author_sort | Pugazhenthan Thangaraju |
| collection | DOAJ |
| description | Abstract INTRODUCTION: Thalidomide is an anti- tumor necrosis factor alpha (TNF-a) drug used mainly in the management of moderate to severe form of Erythema Nodosum Leprosum (ENL). Because of its teratogenic potential it has to be used under proper supervision. Our critical analysis tries to look into the rationale with which it has been used by means of case reports on lepra reaction. METHODS: We looked for the case reports between December 2005 to June 2019 in databases like Pubmed, Embase and other relevant resources. We used search words like “erythema nodosum leprosum(ENL)”, “thalidomide”, “case report” in different combinations to get relevant reports that focus on thalidomide usage atleast once at any time point during management. The information extracted were indication of thalidomide use, dose, response, outcome, complication if any, along with all the demographic details and geographical distribution. RESULTS: We found 41 case reports eligible for analysis.The information was critically evaluated. From the analysis it was found that 7 of the case report mentioned the exact indication, 4 case report showed irrational use of thalidomide in the case of neuritis without use of steroids, 7 showed proper use of Clofazimine prior to thalidomide initiation, 26 case report showed case report of rationale dose range and in 4 case reports clofazimine was used prior to thalidomide along with the rational dose of thalidomide. CONCLUSIONS: This analysis helps to guide the rationale use of thalidomide focussing on few important points that anyone should keep in mind while managing a case of ENL. |
| first_indexed | 2024-12-11T18:14:41Z |
| format | Article |
| id | doaj.art-c629d17b8ea444eb8e35e10892a14b41 |
| institution | Directory Open Access Journal |
| issn | 1678-9849 |
| language | English |
| last_indexed | 2024-12-11T18:14:41Z |
| publishDate | 2020-09-01 |
| publisher | Sociedade Brasileira de Medicina Tropical (SBMT) |
| record_format | Article |
| series | Revista da Sociedade Brasileira de Medicina Tropical |
| spelling | doaj.art-c629d17b8ea444eb8e35e10892a14b412022-12-22T00:55:27ZengSociedade Brasileira de Medicina Tropical (SBMT)Revista da Sociedade Brasileira de Medicina Tropical1678-98492020-09-015310.1590/0037-8682-0454-2019Rationale use of Thalidomide in erythema nodosum leprosum - A non-systematic critical analysis of published case reportsPugazhenthan Thangarajuhttps://orcid.org/0000-0002-4090-2004Sajitha VenkatesanMeenalotchini GurunthalingamShoban BabuTamilselvan TAbstract INTRODUCTION: Thalidomide is an anti- tumor necrosis factor alpha (TNF-a) drug used mainly in the management of moderate to severe form of Erythema Nodosum Leprosum (ENL). Because of its teratogenic potential it has to be used under proper supervision. Our critical analysis tries to look into the rationale with which it has been used by means of case reports on lepra reaction. METHODS: We looked for the case reports between December 2005 to June 2019 in databases like Pubmed, Embase and other relevant resources. We used search words like “erythema nodosum leprosum(ENL)”, “thalidomide”, “case report” in different combinations to get relevant reports that focus on thalidomide usage atleast once at any time point during management. The information extracted were indication of thalidomide use, dose, response, outcome, complication if any, along with all the demographic details and geographical distribution. RESULTS: We found 41 case reports eligible for analysis.The information was critically evaluated. From the analysis it was found that 7 of the case report mentioned the exact indication, 4 case report showed irrational use of thalidomide in the case of neuritis without use of steroids, 7 showed proper use of Clofazimine prior to thalidomide initiation, 26 case report showed case report of rationale dose range and in 4 case reports clofazimine was used prior to thalidomide along with the rational dose of thalidomide. CONCLUSIONS: This analysis helps to guide the rationale use of thalidomide focussing on few important points that anyone should keep in mind while managing a case of ENL.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822020000100333&tlng=enENLManagementSeverityThalidomideRationaleUsage |
| spellingShingle | Pugazhenthan Thangaraju Sajitha Venkatesan Meenalotchini Gurunthalingam Shoban Babu Tamilselvan T Rationale use of Thalidomide in erythema nodosum leprosum - A non-systematic critical analysis of published case reports Revista da Sociedade Brasileira de Medicina Tropical ENL Management Severity Thalidomide Rationale Usage |
| title | Rationale use of Thalidomide in erythema nodosum leprosum - A non-systematic critical analysis of published case reports |
| title_full | Rationale use of Thalidomide in erythema nodosum leprosum - A non-systematic critical analysis of published case reports |
| title_fullStr | Rationale use of Thalidomide in erythema nodosum leprosum - A non-systematic critical analysis of published case reports |
| title_full_unstemmed | Rationale use of Thalidomide in erythema nodosum leprosum - A non-systematic critical analysis of published case reports |
| title_short | Rationale use of Thalidomide in erythema nodosum leprosum - A non-systematic critical analysis of published case reports |
| title_sort | rationale use of thalidomide in erythema nodosum leprosum a non systematic critical analysis of published case reports |
| topic | ENL Management Severity Thalidomide Rationale Usage |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822020000100333&tlng=en |
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