STUDYING ASSOCIATIONS OF TWO COMMON S27P AND -15С→T POLYMORPHISMS OF THE INTERLEUKIN-3 GENE WITH DEVELOPMENT OF ALLERGIC AND NON-ALLERGIC BRONCHIAL ASTHMA IN RUSSIANS FROM THE CENTRAL-CHERNOZEM REGION
Abstract. The purpose of our study was to investigate whether S27P and -15С→T single nucleotide polymorphisms of the IL3 gene are associated with susceptibility to bronchial asthma (BA) in Russians living in the Central-Chernozem region of Russia. DNA samples obtained from 216 unrelated patients wit...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/587 |
| Summary: | Abstract. The purpose of our study was to investigate whether S27P and -15С→T single nucleotide polymorphisms of the IL3 gene are associated with susceptibility to bronchial asthma (BA) in Russians living in the Central-Chernozem region of Russia. DNA samples obtained from 216 unrelated patients with BA and 214 healthy controls were typed for S27P and -15С→T polymorphisms in the IL3 gene by PCR-RFLP methods. Gender-based differences in the distribution of IL3 genotypes have been revealed between controls and patients with asthma. Both S27P and -15С→T polymorphisms were found to associate with common susceptibility to BA predominantly in females (p=0,05). Studied genetic variants of IL3 gene were in strong linkage disequilibrium with each other (p<0,0001). Further studies are required to investigate phenotypic expression of S27P and -15С→T polymorphisms of IL3 gene and to clarify their roles in the pathogenesis of bronchial asthma. |
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| ISSN: | 1563-0625 2313-741X |