Research efficacy of gaseous ozone therapy as an adjuvant to periodontal treatment on oxidative stress mediators in patients with type 2 diabetes: a randomized clinical trial
Abstract Background Chronic inflammation and cumulative oxidative stress have been theorized as two common pathways of the interconnection between periodontitis and diabetes. Improvement in oxidizing status has been demonstrated in periodontal patients with diabetes treated with proper non-surgical...
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| Format: | Article |
| Language: | English |
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BMC
2023-05-01
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| Series: | BMC Oral Health |
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| Online Access: | https://doi.org/10.1186/s12903-023-02985-1 |
| _version_ | 1797827304784658432 |
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| author | Biagio Rapone Elisabetta Ferrara Erda Qorri Francesco Inchingolo Gaetano Isola Paola Dongiovanni Gianluca Martino Tartaglia Antonio Scarano |
| author_facet | Biagio Rapone Elisabetta Ferrara Erda Qorri Francesco Inchingolo Gaetano Isola Paola Dongiovanni Gianluca Martino Tartaglia Antonio Scarano |
| author_sort | Biagio Rapone |
| collection | DOAJ |
| description | Abstract Background Chronic inflammation and cumulative oxidative stress have been theorized as two common pathways of the interconnection between periodontitis and diabetes. Improvement in oxidizing status has been demonstrated in periodontal patients with diabetes treated with proper non-surgical periodontal treatment. In addition to periodontal treatment, Gaseous ozone therapy has been reported to possess anti-inflammatory properties and the ability to stimulate the endogenous antioxidant defence mechanism. To date, the antioxidant effect of gaseous ozone, in addition with periodontal treatment in diabetic patients, has been examined in only one study. The aim of this study was to determine the efficacy of gaseous ozone therapy as an alternative approach to supporting non-surgical periodontal therapy (NSPT), aimed at improving antioxidant machinery and interfering with ROS production on plasma levels in diabetic individuals diagnosed with moderate or severe periodontitis. Methods One hundred and eighty patients with periodontitis and type 2 diabetes mellitus were randomly assigned to receive non-surgical periodontal treatment (NSPT) plus gaseous ozone therapy (A) NSPT alone (B). Clinical and periodontal parameters -Bleeding on probing (BOP), Periodontal pocket depth (PPD), and Clinical attachment Level (CAL)- and plasma levels of oxidant-antioxidant (TOS- TAOS) levels, glutathione (GSH), and malondialdehyde (MDA) were recorded at baseline and at 3- (T1) and at 6-months (T2) after treatment. Results Both treatments were efficacious in reducing clinical parameters. However, there were no significant differences regarding oxidative stress parameters in group A compared to group B. Conclusions In the present study, gaseous ozone therapy did not enhance the effect of periodontal treatment in reducing oxidative stress in plasma levels of periodontitis patients with type II diabetes. Trial registration The study was registered with ISRCTN1728169 (23/07/2022). |
| first_indexed | 2024-04-09T12:46:35Z |
| format | Article |
| id | doaj.art-c62d6a199c2549c9b2f8dee4252358e2 |
| institution | Directory Open Access Journal |
| issn | 1472-6831 |
| language | English |
| last_indexed | 2024-04-09T12:46:35Z |
| publishDate | 2023-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Oral Health |
| spelling | doaj.art-c62d6a199c2549c9b2f8dee4252358e22023-05-14T11:29:57ZengBMCBMC Oral Health1472-68312023-05-0123111110.1186/s12903-023-02985-1Research efficacy of gaseous ozone therapy as an adjuvant to periodontal treatment on oxidative stress mediators in patients with type 2 diabetes: a randomized clinical trialBiagio Rapone0Elisabetta Ferrara1Erda Qorri2Francesco Inchingolo3Gaetano Isola4Paola Dongiovanni5Gianluca Martino Tartaglia6Antonio Scarano7Interdisciplinary Department of Medicine, “Aldo Moro” University of BariDepartment of Medical, Oral and Biotechnological Sciences, University G. d’AnnunzioDean Faculty of Medical Sciences, Albanian UniversityInterdisciplinary Department of Medicine, “Aldo Moro” University of BariDepartment of General Surgery and Medical Surgery Specialties, School of Dentistry, University of CataniaGeneral Medicine and Metabolic Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore PoliclinicoUOC Maxillo-Facial Surgery and Dentistry, Ospedale Maggiore Policlinico, Fondazione IRCCS Ca GrandaDepartment of Innovative Technologies in Medicine and Dentistry, University of Chieti-PescaraAbstract Background Chronic inflammation and cumulative oxidative stress have been theorized as two common pathways of the interconnection between periodontitis and diabetes. Improvement in oxidizing status has been demonstrated in periodontal patients with diabetes treated with proper non-surgical periodontal treatment. In addition to periodontal treatment, Gaseous ozone therapy has been reported to possess anti-inflammatory properties and the ability to stimulate the endogenous antioxidant defence mechanism. To date, the antioxidant effect of gaseous ozone, in addition with periodontal treatment in diabetic patients, has been examined in only one study. The aim of this study was to determine the efficacy of gaseous ozone therapy as an alternative approach to supporting non-surgical periodontal therapy (NSPT), aimed at improving antioxidant machinery and interfering with ROS production on plasma levels in diabetic individuals diagnosed with moderate or severe periodontitis. Methods One hundred and eighty patients with periodontitis and type 2 diabetes mellitus were randomly assigned to receive non-surgical periodontal treatment (NSPT) plus gaseous ozone therapy (A) NSPT alone (B). Clinical and periodontal parameters -Bleeding on probing (BOP), Periodontal pocket depth (PPD), and Clinical attachment Level (CAL)- and plasma levels of oxidant-antioxidant (TOS- TAOS) levels, glutathione (GSH), and malondialdehyde (MDA) were recorded at baseline and at 3- (T1) and at 6-months (T2) after treatment. Results Both treatments were efficacious in reducing clinical parameters. However, there were no significant differences regarding oxidative stress parameters in group A compared to group B. Conclusions In the present study, gaseous ozone therapy did not enhance the effect of periodontal treatment in reducing oxidative stress in plasma levels of periodontitis patients with type II diabetes. Trial registration The study was registered with ISRCTN1728169 (23/07/2022).https://doi.org/10.1186/s12903-023-02985-1PeriodontitisPeriodontal inflammationType 2 diabetesOxidative stressAntioxidant status, pro-oxidant status |
| spellingShingle | Biagio Rapone Elisabetta Ferrara Erda Qorri Francesco Inchingolo Gaetano Isola Paola Dongiovanni Gianluca Martino Tartaglia Antonio Scarano Research efficacy of gaseous ozone therapy as an adjuvant to periodontal treatment on oxidative stress mediators in patients with type 2 diabetes: a randomized clinical trial BMC Oral Health Periodontitis Periodontal inflammation Type 2 diabetes Oxidative stress Antioxidant status, pro-oxidant status |
| title | Research efficacy of gaseous ozone therapy as an adjuvant to periodontal treatment on oxidative stress mediators in patients with type 2 diabetes: a randomized clinical trial |
| title_full | Research efficacy of gaseous ozone therapy as an adjuvant to periodontal treatment on oxidative stress mediators in patients with type 2 diabetes: a randomized clinical trial |
| title_fullStr | Research efficacy of gaseous ozone therapy as an adjuvant to periodontal treatment on oxidative stress mediators in patients with type 2 diabetes: a randomized clinical trial |
| title_full_unstemmed | Research efficacy of gaseous ozone therapy as an adjuvant to periodontal treatment on oxidative stress mediators in patients with type 2 diabetes: a randomized clinical trial |
| title_short | Research efficacy of gaseous ozone therapy as an adjuvant to periodontal treatment on oxidative stress mediators in patients with type 2 diabetes: a randomized clinical trial |
| title_sort | research efficacy of gaseous ozone therapy as an adjuvant to periodontal treatment on oxidative stress mediators in patients with type 2 diabetes a randomized clinical trial |
| topic | Periodontitis Periodontal inflammation Type 2 diabetes Oxidative stress Antioxidant status, pro-oxidant status |
| url | https://doi.org/10.1186/s12903-023-02985-1 |
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