A Review on Current Strategies for Extraction and Purification of Hyaluronic Acid
Since it is known that hyaluronic acid contributes to soft tissue growth, elasticity, and scar reduction, different strategies of producing HA have been explored in order to satisfy the current demand of HA in pharmaceutical products and formulations. The current interest deals with production via b...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/11/6038 |
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| author | Carlos Dariel Rodriguez-Marquez Susana Arteaga-Marin Andrea Rivas-Sánchez Renata Autrique-Hernández Roberto Castro-Muñoz |
| author_facet | Carlos Dariel Rodriguez-Marquez Susana Arteaga-Marin Andrea Rivas-Sánchez Renata Autrique-Hernández Roberto Castro-Muñoz |
| author_sort | Carlos Dariel Rodriguez-Marquez |
| collection | DOAJ |
| description | Since it is known that hyaluronic acid contributes to soft tissue growth, elasticity, and scar reduction, different strategies of producing HA have been explored in order to satisfy the current demand of HA in pharmaceutical products and formulations. The current interest deals with production via bacterial and yeast fermentation and extraction from animal sources; however, the main challenge is the right extraction technique and strategy since the original sources (e.g., fermentation broth) represent a complex system containing a number of components and solutes, which complicates the achievement of high extraction rates and purity. This review sheds light on the main pathways for the production of HA, advantages, and disadvantages, along with the current efforts in extracting and purifying this high-added-value molecule from different sources. Particular emphasis has been placed on specific case studies attempting production and successful recovery. For such works, full details are given together with their relevant outcomes. |
| first_indexed | 2024-03-10T01:16:28Z |
| format | Article |
| id | doaj.art-c62d8adeae2b4bdf94029bc1937fbb2f |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T01:16:28Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-c62d8adeae2b4bdf94029bc1937fbb2f2023-11-23T14:08:26ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-05-012311603810.3390/ijms23116038A Review on Current Strategies for Extraction and Purification of Hyaluronic AcidCarlos Dariel Rodriguez-Marquez0Susana Arteaga-Marin1Andrea Rivas-Sánchez2Renata Autrique-Hernández3Roberto Castro-Muñoz4Tecnologico de Monterrey, Campus Chihuahua, Avenida H. Colegio Militar 4700, Nombre de Dios, Chihuahua 31300, Chihuahua, MexicoTecnologico de Monterrey, Campus Querétaro, Avenida Epigmenio González 500, San Pablo, Santiago de Querétaro 76130, Qro., MexicoTecnologico de Monterrey, Campus Monterrey, Avenida Eugenio Garza Sada 2501 Sur, Tecnológico, Monterrey 64849, N.L., MexicoTecnologico de Monterrey, Campus Querétaro, Avenida Epigmenio González 500, San Pablo, Santiago de Querétaro 76130, Qro., MexicoTecnologico de Monterrey, Campus Toluca, Avenida Eduardo Monroy Cárdenas 2000 San Antonio Buenavista, Toluca de Lerdo 50110, MexicoSince it is known that hyaluronic acid contributes to soft tissue growth, elasticity, and scar reduction, different strategies of producing HA have been explored in order to satisfy the current demand of HA in pharmaceutical products and formulations. The current interest deals with production via bacterial and yeast fermentation and extraction from animal sources; however, the main challenge is the right extraction technique and strategy since the original sources (e.g., fermentation broth) represent a complex system containing a number of components and solutes, which complicates the achievement of high extraction rates and purity. This review sheds light on the main pathways for the production of HA, advantages, and disadvantages, along with the current efforts in extracting and purifying this high-added-value molecule from different sources. Particular emphasis has been placed on specific case studies attempting production and successful recovery. For such works, full details are given together with their relevant outcomes.https://www.mdpi.com/1422-0067/23/11/6038hyaluronic acid (HA)glycosaminoglycanfermentationprecipitationbacterial productionextraction |
| spellingShingle | Carlos Dariel Rodriguez-Marquez Susana Arteaga-Marin Andrea Rivas-Sánchez Renata Autrique-Hernández Roberto Castro-Muñoz A Review on Current Strategies for Extraction and Purification of Hyaluronic Acid International Journal of Molecular Sciences hyaluronic acid (HA) glycosaminoglycan fermentation precipitation bacterial production extraction |
| title | A Review on Current Strategies for Extraction and Purification of Hyaluronic Acid |
| title_full | A Review on Current Strategies for Extraction and Purification of Hyaluronic Acid |
| title_fullStr | A Review on Current Strategies for Extraction and Purification of Hyaluronic Acid |
| title_full_unstemmed | A Review on Current Strategies for Extraction and Purification of Hyaluronic Acid |
| title_short | A Review on Current Strategies for Extraction and Purification of Hyaluronic Acid |
| title_sort | review on current strategies for extraction and purification of hyaluronic acid |
| topic | hyaluronic acid (HA) glycosaminoglycan fermentation precipitation bacterial production extraction |
| url | https://www.mdpi.com/1422-0067/23/11/6038 |
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