Consumption of β-casomorphins-7/5 induce inflammatory immune response in mice gut through Th2 pathway
β-Casomorphins are opioid like bioactive peptides released on digestion of β-casein of milk. In the present study in vivo impact of consumption of β-casomorphins (BCM-7/5) was evaluated on immune response of murine gut. The peptides were given to mice through oral intubation at a dose of 7.5 × 10−8 ...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2014-05-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464614001169 |
| _version_ | 1819294315746164736 |
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| author | Mohammad Raies Ul Haq Rajeev Kapila Vamshi Saliganti |
| author_facet | Mohammad Raies Ul Haq Rajeev Kapila Vamshi Saliganti |
| author_sort | Mohammad Raies Ul Haq |
| collection | DOAJ |
| description | β-Casomorphins are opioid like bioactive peptides released on digestion of β-casein of milk. In the present study in vivo impact of consumption of β-casomorphins (BCM-7/5) was evaluated on immune response of murine gut. The peptides were given to mice through oral intubation at a dose of 7.5 × 10−8 mol/day/animal for 15 days. Oral administration of both peptides individually increased (p < 0.01) phenotypic expression of inflammation associated molecules (MPO, MCP-1, IL-4 and histamine), humoral immune response (IgE, IgG, IgG1/IgG2a), infiltration of leucocytes in intestinal villi and mRNA expression of toll like receptors (TLR-2 and TLR-4) in mice gut. However, no changes in sIgA, IgA+ and goblet cell numbers were recorded. These results clearly indicate that consumption of β-casein derived peptides BCM-7/5 induce inflammatory immune response in gut, most likely through Th2 pathway. |
| first_indexed | 2024-12-24T04:24:22Z |
| format | Article |
| id | doaj.art-c62e4c804d3142d787211c5874ce2ebf |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-24T04:24:22Z |
| publishDate | 2014-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-c62e4c804d3142d787211c5874ce2ebf2022-12-21T17:15:41ZengElsevierJournal of Functional Foods1756-46462014-05-018150160Consumption of β-casomorphins-7/5 induce inflammatory immune response in mice gut through Th2 pathwayMohammad Raies Ul Haq0Rajeev Kapila1Vamshi Saliganti2Animal Biochemistry Division, National Dairy Research Institute, Karnal 132001, IndiaCorresponding author. Tel.: +911842252128; fax: +911842252637..; Animal Biochemistry Division, National Dairy Research Institute, Karnal 132001, IndiaAnimal Biochemistry Division, National Dairy Research Institute, Karnal 132001, Indiaβ-Casomorphins are opioid like bioactive peptides released on digestion of β-casein of milk. In the present study in vivo impact of consumption of β-casomorphins (BCM-7/5) was evaluated on immune response of murine gut. The peptides were given to mice through oral intubation at a dose of 7.5 × 10−8 mol/day/animal for 15 days. Oral administration of both peptides individually increased (p < 0.01) phenotypic expression of inflammation associated molecules (MPO, MCP-1, IL-4 and histamine), humoral immune response (IgE, IgG, IgG1/IgG2a), infiltration of leucocytes in intestinal villi and mRNA expression of toll like receptors (TLR-2 and TLR-4) in mice gut. However, no changes in sIgA, IgA+ and goblet cell numbers were recorded. These results clearly indicate that consumption of β-casein derived peptides BCM-7/5 induce inflammatory immune response in gut, most likely through Th2 pathway.http://www.sciencedirect.com/science/article/pii/S1756464614001169β-CasomorphinsBCM-7BCM-5InflammationHumoral immune responseCytokines |
| spellingShingle | Mohammad Raies Ul Haq Rajeev Kapila Vamshi Saliganti Consumption of β-casomorphins-7/5 induce inflammatory immune response in mice gut through Th2 pathway Journal of Functional Foods β-Casomorphins BCM-7 BCM-5 Inflammation Humoral immune response Cytokines |
| title | Consumption of β-casomorphins-7/5 induce inflammatory immune response in mice gut through Th2 pathway |
| title_full | Consumption of β-casomorphins-7/5 induce inflammatory immune response in mice gut through Th2 pathway |
| title_fullStr | Consumption of β-casomorphins-7/5 induce inflammatory immune response in mice gut through Th2 pathway |
| title_full_unstemmed | Consumption of β-casomorphins-7/5 induce inflammatory immune response in mice gut through Th2 pathway |
| title_short | Consumption of β-casomorphins-7/5 induce inflammatory immune response in mice gut through Th2 pathway |
| title_sort | consumption of β casomorphins 7 5 induce inflammatory immune response in mice gut through th2 pathway |
| topic | β-Casomorphins BCM-7 BCM-5 Inflammation Humoral immune response Cytokines |
| url | http://www.sciencedirect.com/science/article/pii/S1756464614001169 |
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