Gestational Trophoblastic Disease at Sultan Qaboos University Hospital: Prevalence, Risk Factors, Histological Features, Sonographic Findings, and Outcomes
Objectives: We sought to assess the prevalence of gestational trophoblastic diseases (GTD) among pregnant women at Sultan Qaboos University Hospital (SQUH) and compare our results with the international studies. We also sought to determine the risk factors, histological features, sonographic finding...
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| Format: | Article |
| Language: | English |
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Oman Medical Specialty Board
2019-05-01
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| Series: | Oman Medical Journal |
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| Online Access: | http://www.omjournal.org/articleDetails.aspx?coType=1&aId=2453 |
| _version_ | 1828279769771278336 |
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| author | Nihal Al Riyami Marwa Al Riyami Al Thuriya Al Hajri Shaimaa Al Saidi Bushra Salman Moza Al Kalbani |
| author_facet | Nihal Al Riyami Marwa Al Riyami Al Thuriya Al Hajri Shaimaa Al Saidi Bushra Salman Moza Al Kalbani |
| author_sort | Nihal Al Riyami |
| collection | DOAJ |
| description | Objectives: We sought to assess the prevalence of gestational trophoblastic diseases (GTD) among pregnant women at Sultan Qaboos University Hospital (SQUH) and compare our results with the international studies. We also sought to determine the risk factors, histological features, sonographic findings, and outcomes in women with GTD. Methods: We conducted a retrospective cohort study of all women diagnosed with GTD and followed at SQUH between November 2007 and October 2015. We collected data on maternal demographics, risk factors, sonographic features, histological diagnosis, follow-up period, and chemotherapy treatment from the hospital information system. Results: Sixty-four women with GTD were included in the study with a mean age of 31.0±7.5 years, mean gravidity 4.0, and parity 2.0. The prevalence of GTD was 0.3% (one in 386 births), and the most common risk factors were increased maternal age and multiparity. A partial hydatidiform mole was diagnosed in 54.7%, complete hydatidiform mole in 43.8%, and invasive mole in 1.6% of women. Eleven percent of women required chemotherapy. Typical ultrasound features for partial molar pregnancy were present in 54.7% of our sample, while snowstorm appearance was seen in 89.3% of those with complete mole. Negative beta-human chorionic gonadotropin was achieved 70 days after diagnosis in 41 women. Conclusions: The awareness of the risks and complications of GTD among physicians with close follow-up is paramount. There is a need to establish a national registry of GTD cases in Oman. |
| first_indexed | 2024-04-13T07:48:30Z |
| format | Article |
| id | doaj.art-c6309f42bcda4f07a50b49b153a14785 |
| institution | Directory Open Access Journal |
| issn | 1999-768X 2070-5204 |
| language | English |
| last_indexed | 2024-04-13T07:48:30Z |
| publishDate | 2019-05-01 |
| publisher | Oman Medical Specialty Board |
| record_format | Article |
| series | Oman Medical Journal |
| spelling | doaj.art-c6309f42bcda4f07a50b49b153a147852022-12-22T02:55:37ZengOman Medical Specialty BoardOman Medical Journal1999-768X2070-52042019-05-0134320020410.5001/omj.2019.39Gestational Trophoblastic Disease at Sultan Qaboos University Hospital: Prevalence, Risk Factors, Histological Features, Sonographic Findings, and OutcomesNihal Al Riyami0Marwa Al Riyami1Al Thuriya Al Hajri2Shaimaa Al Saidi3Bushra Salman4Moza Al Kalbani5Department of Obstetrics and Gynecology, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, OmanDepartment of Pathology, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, OmanCollege of Medicine and Health Sciences, Sultan Qaboos University, Muscat, OmanCollege of Medicine and Health Sciences, Sultan Qaboos University, Muscat, OmanDepartment of Pharmacy, Sultan Qaboos University Hospital, Muscat, OmanDepartment of Obstetrics and Gynecology, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, OmanObjectives: We sought to assess the prevalence of gestational trophoblastic diseases (GTD) among pregnant women at Sultan Qaboos University Hospital (SQUH) and compare our results with the international studies. We also sought to determine the risk factors, histological features, sonographic findings, and outcomes in women with GTD. Methods: We conducted a retrospective cohort study of all women diagnosed with GTD and followed at SQUH between November 2007 and October 2015. We collected data on maternal demographics, risk factors, sonographic features, histological diagnosis, follow-up period, and chemotherapy treatment from the hospital information system. Results: Sixty-four women with GTD were included in the study with a mean age of 31.0±7.5 years, mean gravidity 4.0, and parity 2.0. The prevalence of GTD was 0.3% (one in 386 births), and the most common risk factors were increased maternal age and multiparity. A partial hydatidiform mole was diagnosed in 54.7%, complete hydatidiform mole in 43.8%, and invasive mole in 1.6% of women. Eleven percent of women required chemotherapy. Typical ultrasound features for partial molar pregnancy were present in 54.7% of our sample, while snowstorm appearance was seen in 89.3% of those with complete mole. Negative beta-human chorionic gonadotropin was achieved 70 days after diagnosis in 41 women. Conclusions: The awareness of the risks and complications of GTD among physicians with close follow-up is paramount. There is a need to establish a national registry of GTD cases in Oman.http://www.omjournal.org/articleDetails.aspx?coType=1&aId=2453Molar PregnancyGestational Trophoblastic Disease |
| spellingShingle | Nihal Al Riyami Marwa Al Riyami Al Thuriya Al Hajri Shaimaa Al Saidi Bushra Salman Moza Al Kalbani Gestational Trophoblastic Disease at Sultan Qaboos University Hospital: Prevalence, Risk Factors, Histological Features, Sonographic Findings, and Outcomes Oman Medical Journal Molar Pregnancy Gestational Trophoblastic Disease |
| title | Gestational Trophoblastic Disease at Sultan Qaboos University Hospital: Prevalence, Risk Factors, Histological Features, Sonographic Findings, and Outcomes |
| title_full | Gestational Trophoblastic Disease at Sultan Qaboos University Hospital: Prevalence, Risk Factors, Histological Features, Sonographic Findings, and Outcomes |
| title_fullStr | Gestational Trophoblastic Disease at Sultan Qaboos University Hospital: Prevalence, Risk Factors, Histological Features, Sonographic Findings, and Outcomes |
| title_full_unstemmed | Gestational Trophoblastic Disease at Sultan Qaboos University Hospital: Prevalence, Risk Factors, Histological Features, Sonographic Findings, and Outcomes |
| title_short | Gestational Trophoblastic Disease at Sultan Qaboos University Hospital: Prevalence, Risk Factors, Histological Features, Sonographic Findings, and Outcomes |
| title_sort | gestational trophoblastic disease at sultan qaboos university hospital prevalence risk factors histological features sonographic findings and outcomes |
| topic | Molar Pregnancy Gestational Trophoblastic Disease |
| url | http://www.omjournal.org/articleDetails.aspx?coType=1&aId=2453 |
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