The Elevation of Pancreatic Enzymes in Serum and Their Distribution at Different Stages of Renal Insufficiency Among Diabetic Patients Attending Goba Referral Hospital
Tadele Regasa,1 Yohannes Dinku,1 Bereket Gezahegn,1 Zegeye Feleke,2 Zegeye Regassa,2 Ayele Mamo,1 Tesfaye Assefa,2 Habtamu Gezahegn,1 Damtew Solomon,1 Daniel Atlaw,1 Mengistu Dessie3 1School of medicine, Madda Walabu University, Goba, Ethiopia; 2School of Health Science, Madda Walabu University, Gob...
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| Format: | Article |
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Dove Medical Press
2022-07-01
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| Series: | Diabetes, Metabolic Syndrome and Obesity |
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| Online Access: | https://www.dovepress.com/the-elevation-of-pancreatic-enzymes-in-serum-and-their-distribution-at-peer-reviewed-fulltext-article-DMSO |
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| author | Regasa T Dinku Y Gezahegn B Feleke Z Regassa Z Mamo A Assefa T Gezahegn H Solomon D Atlaw D Dessie M |
| author_facet | Regasa T Dinku Y Gezahegn B Feleke Z Regassa Z Mamo A Assefa T Gezahegn H Solomon D Atlaw D Dessie M |
| author_sort | Regasa T |
| collection | DOAJ |
| description | Tadele Regasa,1 Yohannes Dinku,1 Bereket Gezahegn,1 Zegeye Feleke,2 Zegeye Regassa,2 Ayele Mamo,1 Tesfaye Assefa,2 Habtamu Gezahegn,1 Damtew Solomon,1 Daniel Atlaw,1 Mengistu Dessie3 1School of medicine, Madda Walabu University, Goba, Ethiopia; 2School of Health Science, Madda Walabu University, Goba, Ethiopia; 3School of Medicine, Wolaita Sodo University, Wolaita Sodo, EthiopiaCorrespondence: Tadele Regasa, Tel +251922311812, Email tdlrgs104@gmail.comIntroduction: Acute pancreatitis is auto-cell destruction that is manifested by increased leakage of amylase and lipase into circulation. During pancreatitis, the activity of serum amylase and lipase is elevated three times above the upper limit of the normal range. This elevation was observed in both prediabetic and diabetic patients. Severe acute pancreatitis can result in acute kidney injury and other multi-organ dysfunction, which is one of the reasons for death.Objective: This study aimed to evaluate the elevation of serum amylase and lipase and their distribution at different stages of renal insufficiency among diabetic patients.Methods: This study included 286 diabetic patients (36 type 1 and 250 type 2), and data were collected from May 1 to June 30, 2019. The study design used was an institution-based cross-sectional study. A face-to-face interview was used to collect data, and serum creatinine, amylase, and lipase levels were measured using a chemistry analyzer. For data entry and statistical analysis, respectively, Epidata software version 3.02 and SPSS version 21 were used.Results: The mean serum amylase among diabetic patients suffering from G3b and G4 was 106.79 IU/L ± 118.18 IU/L and 104.85 ± 90.42 IU/L, respectively. Their mean serum lipase activity was 105.07 IU/L ± 127.54 IU/L and 106.98 IU/L ± 88.35 IU/L, respectively. Serum lipase activity was elevated above the normal range and three times above the upper limit of the normal range with a magnitude of 11.2% and 4.2%, respectively. Similarly, 9.1% and 0.7% of diabetic patients had increased serum amylase above the normal range and three-fold above the normal range, respectively.Conclusion: As glomerular filtration decreases, particularly in moderate-to-severe chronic kidney disease, serum amylase and lipase activity rise above the upper limit.Keywords: acute pancreatitis, chronic kidney disease, diabetes mellitus, serum amylase, serum lipase |
| first_indexed | 2024-03-12T19:11:29Z |
| format | Article |
| id | doaj.art-c63221fb87554ae2b123f24d1ea793f9 |
| institution | Directory Open Access Journal |
| issn | 1178-7007 |
| language | English |
| last_indexed | 2024-03-12T19:11:29Z |
| publishDate | 2022-07-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj.art-c63221fb87554ae2b123f24d1ea793f92023-08-02T05:55:59ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072022-07-01Volume 152087209376648The Elevation of Pancreatic Enzymes in Serum and Their Distribution at Different Stages of Renal Insufficiency Among Diabetic Patients Attending Goba Referral HospitalRegasa TDinku YGezahegn BFeleke ZRegassa ZMamo AAssefa TGezahegn HSolomon DAtlaw DDessie MTadele Regasa,1 Yohannes Dinku,1 Bereket Gezahegn,1 Zegeye Feleke,2 Zegeye Regassa,2 Ayele Mamo,1 Tesfaye Assefa,2 Habtamu Gezahegn,1 Damtew Solomon,1 Daniel Atlaw,1 Mengistu Dessie3 1School of medicine, Madda Walabu University, Goba, Ethiopia; 2School of Health Science, Madda Walabu University, Goba, Ethiopia; 3School of Medicine, Wolaita Sodo University, Wolaita Sodo, EthiopiaCorrespondence: Tadele Regasa, Tel +251922311812, Email tdlrgs104@gmail.comIntroduction: Acute pancreatitis is auto-cell destruction that is manifested by increased leakage of amylase and lipase into circulation. During pancreatitis, the activity of serum amylase and lipase is elevated three times above the upper limit of the normal range. This elevation was observed in both prediabetic and diabetic patients. Severe acute pancreatitis can result in acute kidney injury and other multi-organ dysfunction, which is one of the reasons for death.Objective: This study aimed to evaluate the elevation of serum amylase and lipase and their distribution at different stages of renal insufficiency among diabetic patients.Methods: This study included 286 diabetic patients (36 type 1 and 250 type 2), and data were collected from May 1 to June 30, 2019. The study design used was an institution-based cross-sectional study. A face-to-face interview was used to collect data, and serum creatinine, amylase, and lipase levels were measured using a chemistry analyzer. For data entry and statistical analysis, respectively, Epidata software version 3.02 and SPSS version 21 were used.Results: The mean serum amylase among diabetic patients suffering from G3b and G4 was 106.79 IU/L ± 118.18 IU/L and 104.85 ± 90.42 IU/L, respectively. Their mean serum lipase activity was 105.07 IU/L ± 127.54 IU/L and 106.98 IU/L ± 88.35 IU/L, respectively. Serum lipase activity was elevated above the normal range and three times above the upper limit of the normal range with a magnitude of 11.2% and 4.2%, respectively. Similarly, 9.1% and 0.7% of diabetic patients had increased serum amylase above the normal range and three-fold above the normal range, respectively.Conclusion: As glomerular filtration decreases, particularly in moderate-to-severe chronic kidney disease, serum amylase and lipase activity rise above the upper limit.Keywords: acute pancreatitis, chronic kidney disease, diabetes mellitus, serum amylase, serum lipasehttps://www.dovepress.com/the-elevation-of-pancreatic-enzymes-in-serum-and-their-distribution-at-peer-reviewed-fulltext-article-DMSOacute pancreatitischronic kidney diseasediabetes mellitusserum amylaseserum lipase |
| spellingShingle | Regasa T Dinku Y Gezahegn B Feleke Z Regassa Z Mamo A Assefa T Gezahegn H Solomon D Atlaw D Dessie M The Elevation of Pancreatic Enzymes in Serum and Their Distribution at Different Stages of Renal Insufficiency Among Diabetic Patients Attending Goba Referral Hospital Diabetes, Metabolic Syndrome and Obesity acute pancreatitis chronic kidney disease diabetes mellitus serum amylase serum lipase |
| title | The Elevation of Pancreatic Enzymes in Serum and Their Distribution at Different Stages of Renal Insufficiency Among Diabetic Patients Attending Goba Referral Hospital |
| title_full | The Elevation of Pancreatic Enzymes in Serum and Their Distribution at Different Stages of Renal Insufficiency Among Diabetic Patients Attending Goba Referral Hospital |
| title_fullStr | The Elevation of Pancreatic Enzymes in Serum and Their Distribution at Different Stages of Renal Insufficiency Among Diabetic Patients Attending Goba Referral Hospital |
| title_full_unstemmed | The Elevation of Pancreatic Enzymes in Serum and Their Distribution at Different Stages of Renal Insufficiency Among Diabetic Patients Attending Goba Referral Hospital |
| title_short | The Elevation of Pancreatic Enzymes in Serum and Their Distribution at Different Stages of Renal Insufficiency Among Diabetic Patients Attending Goba Referral Hospital |
| title_sort | elevation of pancreatic enzymes in serum and their distribution at different stages of renal insufficiency among diabetic patients attending goba referral hospital |
| topic | acute pancreatitis chronic kidney disease diabetes mellitus serum amylase serum lipase |
| url | https://www.dovepress.com/the-elevation-of-pancreatic-enzymes-in-serum-and-their-distribution-at-peer-reviewed-fulltext-article-DMSO |
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