Serum cystatin C and stroke risk: a national cohort and Mendelian randomization study
PurposeThe debate over the causal and longitudinal association between cystatin C and stroke in older adults persists. Our aim was to assess the link between cystatin C levels, both measured and genetically predicted, and stroke risk.MethodsThis study employed a retrospective cohort design using sam...
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1355948/full |
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| author | Yitian Qi Xinyun Shang Tianjiao Han Ning Han Ziwei Jiang Han Yan Siqi Yue Qichao Sun Lin Liu Cancan Cui |
| author_facet | Yitian Qi Xinyun Shang Tianjiao Han Ning Han Ziwei Jiang Han Yan Siqi Yue Qichao Sun Lin Liu Cancan Cui |
| author_sort | Yitian Qi |
| collection | DOAJ |
| description | PurposeThe debate over the causal and longitudinal association between cystatin C and stroke in older adults persists. Our aim was to assess the link between cystatin C levels, both measured and genetically predicted, and stroke risk.MethodsThis study employed a retrospective cohort design using samples of the China Health and Retirement Longitudinal Study (CHARLS), which is a nationally representative cohort recruiting individuals aged 45 years or above. A multivariate logistic model and the two-sample Mendelian randomization framework were used to investigate the longitudinal and genetically predicted effect of serum cystatin C on stroke.ResultsThe study population had a mean age of 59.6 (SD ±9.5), with 2,996 (46.1%) women. After adjusting for confounding factors, compared to those in the first quartile of cystatin C, those in the last quartile had the greatest risk of stroke incidence [odds ratio (OR), 1.380; 95% confidence interval (CI), 1.046–1.825]. The Mendelian randomization analysis showed that a genetically predicted cystatin C level was positively associated with total stroke (OR by inverse variance-weighted method, 1.114; 95% CI, 1.041–1.192).ConclusionsThis national cohort study suggests that higher serum cystatin C is associated with an increased risk of total stroke, which is further supported by Mendelian randomization. |
| first_indexed | 2024-04-24T10:58:57Z |
| format | Article |
| id | doaj.art-c634606bd7ae4a38829f2b2939c8f1a7 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-24T10:58:57Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-c634606bd7ae4a38829f2b2939c8f1a72024-04-12T04:27:22ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-04-011510.3389/fendo.2024.13559481355948Serum cystatin C and stroke risk: a national cohort and Mendelian randomization studyYitian Qi0Xinyun Shang1Tianjiao Han2Ning Han3Ziwei Jiang4Han Yan5Siqi Yue6Qichao Sun7Lin Liu8Cancan Cui9China-Japan Union Hospital of Jilin University, Jilin University, Changchun, Jilin, ChinaChina-Japan Union Hospital of Jilin University, Jilin University, Changchun, Jilin, ChinaChina-Japan Union Hospital of Jilin University, Jilin University, Changchun, Jilin, ChinaChina-Japan Union Hospital of Jilin University, Jilin University, Changchun, Jilin, ChinaChina-Japan Union Hospital of Jilin University, Jilin University, Changchun, Jilin, ChinaChina-Japan Union Hospital of Jilin University, Jilin University, Changchun, Jilin, ChinaChina-Japan Union Hospital of Jilin University, Jilin University, Changchun, Jilin, ChinaThe First Bethune Hospital of Jilin University, Jilin University, Changchun, Jilin, ChinaChina-Japan Union Hospital of Jilin University, Jilin University, Changchun, Jilin, ChinaChina-Japan Union Hospital of Jilin University, Jilin University, Changchun, Jilin, ChinaPurposeThe debate over the causal and longitudinal association between cystatin C and stroke in older adults persists. Our aim was to assess the link between cystatin C levels, both measured and genetically predicted, and stroke risk.MethodsThis study employed a retrospective cohort design using samples of the China Health and Retirement Longitudinal Study (CHARLS), which is a nationally representative cohort recruiting individuals aged 45 years or above. A multivariate logistic model and the two-sample Mendelian randomization framework were used to investigate the longitudinal and genetically predicted effect of serum cystatin C on stroke.ResultsThe study population had a mean age of 59.6 (SD ±9.5), with 2,996 (46.1%) women. After adjusting for confounding factors, compared to those in the first quartile of cystatin C, those in the last quartile had the greatest risk of stroke incidence [odds ratio (OR), 1.380; 95% confidence interval (CI), 1.046–1.825]. The Mendelian randomization analysis showed that a genetically predicted cystatin C level was positively associated with total stroke (OR by inverse variance-weighted method, 1.114; 95% CI, 1.041–1.192).ConclusionsThis national cohort study suggests that higher serum cystatin C is associated with an increased risk of total stroke, which is further supported by Mendelian randomization.https://www.frontiersin.org/articles/10.3389/fendo.2024.1355948/fullcystatin CstrokeEGFRcohort studyMendelian randomization |
| spellingShingle | Yitian Qi Xinyun Shang Tianjiao Han Ning Han Ziwei Jiang Han Yan Siqi Yue Qichao Sun Lin Liu Cancan Cui Serum cystatin C and stroke risk: a national cohort and Mendelian randomization study Frontiers in Endocrinology cystatin C stroke EGFR cohort study Mendelian randomization |
| title | Serum cystatin C and stroke risk: a national cohort and Mendelian randomization study |
| title_full | Serum cystatin C and stroke risk: a national cohort and Mendelian randomization study |
| title_fullStr | Serum cystatin C and stroke risk: a national cohort and Mendelian randomization study |
| title_full_unstemmed | Serum cystatin C and stroke risk: a national cohort and Mendelian randomization study |
| title_short | Serum cystatin C and stroke risk: a national cohort and Mendelian randomization study |
| title_sort | serum cystatin c and stroke risk a national cohort and mendelian randomization study |
| topic | cystatin C stroke EGFR cohort study Mendelian randomization |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1355948/full |
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