LIPID METABOLISM CORRECTION BY ANTISENSE TECHNOLOGY
Antisense oligonucleotides (ASO) technology in elaboration of drugs for lipid metabolism correction is discussed. The main ASO types and modes of its action on the target mRNA are analyzed. Advantages and disadvantages of different ASO are considered in the context of requirements for their therapeu...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Столичная издательская компания
2015-09-01
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| Series: | Рациональная фармакотерапия в кардиологии |
| Subjects: | |
| Online Access: | https://www.rpcardio.online/jour/article/view/229 |
| _version_ | 1826949913690243072 |
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| author | O. I. Afanasieva S. N. Pokrovsky |
| author_facet | O. I. Afanasieva S. N. Pokrovsky |
| author_sort | O. I. Afanasieva |
| collection | DOAJ |
| description | Antisense oligonucleotides (ASO) technology in elaboration of drugs for lipid metabolism correction is discussed. The main ASO types and modes of its action on the target mRNA are analyzed. Advantages and disadvantages of different ASO are considered in the context of requirements for their therapeutic applications.Methods of ASO chemical modification; advantages and disadvantages of different ways of ASO delivery into the cells; developments state of ASO-drugs for therapy of lipid metabolism disturbances; data from clinical trials of these drugs are described. |
| first_indexed | 2024-03-08T14:06:20Z |
| format | Article |
| id | doaj.art-c6369ef43e3b42ce8e267593413927fd |
| institution | Directory Open Access Journal |
| issn | 1819-6446 2225-3653 |
| language | English |
| last_indexed | 2025-02-17T22:22:29Z |
| publishDate | 2015-09-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj.art-c6369ef43e3b42ce8e267593413927fd2024-12-04T11:48:00ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532015-09-019553254110.20996/1819-6446-2013-9-5-532-541229LIPID METABOLISM CORRECTION BY ANTISENSE TECHNOLOGYO. I. Afanasieva0S. N. Pokrovsky1Russian Cardiology Research and Production Complex, MoscowRussian Cardiology Research and Production Complex, MoscowAntisense oligonucleotides (ASO) technology in elaboration of drugs for lipid metabolism correction is discussed. The main ASO types and modes of its action on the target mRNA are analyzed. Advantages and disadvantages of different ASO are considered in the context of requirements for their therapeutic applications.Methods of ASO chemical modification; advantages and disadvantages of different ways of ASO delivery into the cells; developments state of ASO-drugs for therapy of lipid metabolism disturbances; data from clinical trials of these drugs are described.https://www.rpcardio.online/jour/article/view/229antisense therapyantisense oligonucleotideslipid metabolism disturbancescardiovascular disease |
| spellingShingle | O. I. Afanasieva S. N. Pokrovsky LIPID METABOLISM CORRECTION BY ANTISENSE TECHNOLOGY Рациональная фармакотерапия в кардиологии antisense therapy antisense oligonucleotides lipid metabolism disturbances cardiovascular disease |
| title | LIPID METABOLISM CORRECTION BY ANTISENSE TECHNOLOGY |
| title_full | LIPID METABOLISM CORRECTION BY ANTISENSE TECHNOLOGY |
| title_fullStr | LIPID METABOLISM CORRECTION BY ANTISENSE TECHNOLOGY |
| title_full_unstemmed | LIPID METABOLISM CORRECTION BY ANTISENSE TECHNOLOGY |
| title_short | LIPID METABOLISM CORRECTION BY ANTISENSE TECHNOLOGY |
| title_sort | lipid metabolism correction by antisense technology |
| topic | antisense therapy antisense oligonucleotides lipid metabolism disturbances cardiovascular disease |
| url | https://www.rpcardio.online/jour/article/view/229 |
| work_keys_str_mv | AT oiafanasieva lipidmetabolismcorrectionbyantisensetechnology AT snpokrovsky lipidmetabolismcorrectionbyantisensetechnology |