Extracellular Vesicle-Based Therapeutics in Neurological Disorders
Neurological diseases remain some of the major causes of death and disability in the world. Few types of drugs and insufficient delivery across the blood–brain barrier limit the treatment of neurological disorders. The past two decades have seen the rapid development of extracellular vesicle-based t...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/12/2652 |
| _version_ | 1797455744254083072 |
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| author | Yiwen Yuan Jian Sun Tongyao You Weiwei Shen Wenqing Xu Qiang Dong Mei Cui |
| author_facet | Yiwen Yuan Jian Sun Tongyao You Weiwei Shen Wenqing Xu Qiang Dong Mei Cui |
| author_sort | Yiwen Yuan |
| collection | DOAJ |
| description | Neurological diseases remain some of the major causes of death and disability in the world. Few types of drugs and insufficient delivery across the blood–brain barrier limit the treatment of neurological disorders. The past two decades have seen the rapid development of extracellular vesicle-based therapeutics in many fields. As the physiological and pathophysiological roles of extracellular vesicles are recognized in neurological diseases, they have become promising therapeutics and targets for therapeutic interventions. Moreover, advanced nanomedicine technologies have explored the potential of extracellular vesicles as drug delivery systems in neurological diseases. In this review, we discussed the preclinical strategies for extracellular vesicle-based therapeutics in neurological disorders and the struggles involved in their clinical application. |
| first_indexed | 2024-03-09T15:58:43Z |
| format | Article |
| id | doaj.art-c6370d722fe040fb8c6563e4ebdfe70e |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T15:58:43Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-c6370d722fe040fb8c6563e4ebdfe70e2023-11-24T17:19:39ZengMDPI AGPharmaceutics1999-49232022-11-011412265210.3390/pharmaceutics14122652Extracellular Vesicle-Based Therapeutics in Neurological DisordersYiwen Yuan0Jian Sun1Tongyao You2Weiwei Shen3Wenqing Xu4Qiang Dong5Mei Cui6Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200031, ChinaDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai 200031, ChinaDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai 200031, ChinaDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai 200031, ChinaDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai 200031, ChinaDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai 200031, ChinaDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai 200031, ChinaNeurological diseases remain some of the major causes of death and disability in the world. Few types of drugs and insufficient delivery across the blood–brain barrier limit the treatment of neurological disorders. The past two decades have seen the rapid development of extracellular vesicle-based therapeutics in many fields. As the physiological and pathophysiological roles of extracellular vesicles are recognized in neurological diseases, they have become promising therapeutics and targets for therapeutic interventions. Moreover, advanced nanomedicine technologies have explored the potential of extracellular vesicles as drug delivery systems in neurological diseases. In this review, we discussed the preclinical strategies for extracellular vesicle-based therapeutics in neurological disorders and the struggles involved in their clinical application.https://www.mdpi.com/1999-4923/14/12/2652extracellular vesiclesneurological disordersmesenchymal stem cellsdrug deliverytherapeuticsneurodegenerative diseases |
| spellingShingle | Yiwen Yuan Jian Sun Tongyao You Weiwei Shen Wenqing Xu Qiang Dong Mei Cui Extracellular Vesicle-Based Therapeutics in Neurological Disorders Pharmaceutics extracellular vesicles neurological disorders mesenchymal stem cells drug delivery therapeutics neurodegenerative diseases |
| title | Extracellular Vesicle-Based Therapeutics in Neurological Disorders |
| title_full | Extracellular Vesicle-Based Therapeutics in Neurological Disorders |
| title_fullStr | Extracellular Vesicle-Based Therapeutics in Neurological Disorders |
| title_full_unstemmed | Extracellular Vesicle-Based Therapeutics in Neurological Disorders |
| title_short | Extracellular Vesicle-Based Therapeutics in Neurological Disorders |
| title_sort | extracellular vesicle based therapeutics in neurological disorders |
| topic | extracellular vesicles neurological disorders mesenchymal stem cells drug delivery therapeutics neurodegenerative diseases |
| url | https://www.mdpi.com/1999-4923/14/12/2652 |
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