Microwave-Assisted Synthesis of some Novel Azoles and Azolopyrimidines as Antimicrobial Agents
In this study, new derivatives of pyrazole, isoxazole, pyrazolylthiazole, and azolopyrimidine having a thiophene ring were synthesized under microwave irradiation. Their pharmacological activity toward bacteria and fungi inhibition was screened and compared to the references Chloramphenicol and Trim...
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-02-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/22/3/346 |
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| author | Sobhi M. Gomha Thoraya A. Farghaly Yahia Nasser Mabkhot Mohie E. M. Zayed Amany M. G. Mohamed |
| author_facet | Sobhi M. Gomha Thoraya A. Farghaly Yahia Nasser Mabkhot Mohie E. M. Zayed Amany M. G. Mohamed |
| author_sort | Sobhi M. Gomha |
| collection | DOAJ |
| description | In this study, new derivatives of pyrazole, isoxazole, pyrazolylthiazole, and azolopyrimidine having a thiophene ring were synthesized under microwave irradiation. Their pharmacological activity toward bacteria and fungi inhibition was screened and compared to the references Chloramphenicol and Trimethoprim/sulphamethoxazole. The antimicrobial results of the investigated compounds revealed promising results and some derivatives have activities similar to the references used. |
| first_indexed | 2024-12-23T19:13:45Z |
| format | Article |
| id | doaj.art-c63ac14277064fd3b6f9aba91b43b56c |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-23T19:13:45Z |
| publishDate | 2017-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-c63ac14277064fd3b6f9aba91b43b56c2022-12-21T17:34:22ZengMDPI AGMolecules1420-30492017-02-0122334610.3390/molecules22030346molecules22030346Microwave-Assisted Synthesis of some Novel Azoles and Azolopyrimidines as Antimicrobial AgentsSobhi M. Gomha0Thoraya A. Farghaly1Yahia Nasser Mabkhot2Mohie E. M. Zayed3Amany M. G. Mohamed4Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, EgyptDepartment of Chemistry, Faculty of Science, Cairo University, Giza 12613, EgyptDepartment of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh-11451, Saudi ArabiaChemistry Department, Faculty of Science, King Abdulaziz University, Jeddah B.O. 208203, Saudi ArabiaDepartment of Chemistry, Faculty of Science, Cairo University, Giza 12613, EgyptIn this study, new derivatives of pyrazole, isoxazole, pyrazolylthiazole, and azolopyrimidine having a thiophene ring were synthesized under microwave irradiation. Their pharmacological activity toward bacteria and fungi inhibition was screened and compared to the references Chloramphenicol and Trimethoprim/sulphamethoxazole. The antimicrobial results of the investigated compounds revealed promising results and some derivatives have activities similar to the references used.http://www.mdpi.com/1420-3049/22/3/346thiophenespyrazolesthiazolesantimicrobial activitymicrowave irradiation |
| spellingShingle | Sobhi M. Gomha Thoraya A. Farghaly Yahia Nasser Mabkhot Mohie E. M. Zayed Amany M. G. Mohamed Microwave-Assisted Synthesis of some Novel Azoles and Azolopyrimidines as Antimicrobial Agents Molecules thiophenes pyrazoles thiazoles antimicrobial activity microwave irradiation |
| title | Microwave-Assisted Synthesis of some Novel Azoles and Azolopyrimidines as Antimicrobial Agents |
| title_full | Microwave-Assisted Synthesis of some Novel Azoles and Azolopyrimidines as Antimicrobial Agents |
| title_fullStr | Microwave-Assisted Synthesis of some Novel Azoles and Azolopyrimidines as Antimicrobial Agents |
| title_full_unstemmed | Microwave-Assisted Synthesis of some Novel Azoles and Azolopyrimidines as Antimicrobial Agents |
| title_short | Microwave-Assisted Synthesis of some Novel Azoles and Azolopyrimidines as Antimicrobial Agents |
| title_sort | microwave assisted synthesis of some novel azoles and azolopyrimidines as antimicrobial agents |
| topic | thiophenes pyrazoles thiazoles antimicrobial activity microwave irradiation |
| url | http://www.mdpi.com/1420-3049/22/3/346 |
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