Lifestyle and Dietary Habits Affect Plasma Levels of Specific Cytokines in Healthy Subjects
Low-grade chronic inflammation (LGCI) is a common feature of non-communicable diseases. Cytokines play a crucial role in LGCI. This study aimed to assess how LGCI risk factors [e.g., age, body mass index (BMI), smoke, physical activity, and diet] may impact on specific cytokine levels in a healthy p...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.913176/full |
| _version_ | 1818248923822686208 |
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| author | Vittoria D'Esposito Vittoria D'Esposito Michele Francesco Di Tolla Manuela Lecce Francesco Cavalli Michele Libutti Saverio Misso Serena Cabaro Serena Cabaro Maria Rosaria Ambrosio Maria Rosaria Ambrosio Alessia Parascandolo Bianca Covelli Giuseppe Perruolo Mario Sansone Pietro Formisano Pietro Formisano |
| author_facet | Vittoria D'Esposito Vittoria D'Esposito Michele Francesco Di Tolla Manuela Lecce Francesco Cavalli Michele Libutti Saverio Misso Serena Cabaro Serena Cabaro Maria Rosaria Ambrosio Maria Rosaria Ambrosio Alessia Parascandolo Bianca Covelli Giuseppe Perruolo Mario Sansone Pietro Formisano Pietro Formisano |
| author_sort | Vittoria D'Esposito |
| collection | DOAJ |
| description | Low-grade chronic inflammation (LGCI) is a common feature of non-communicable diseases. Cytokines play a crucial role in LGCI. This study aimed to assess how LGCI risk factors [e.g., age, body mass index (BMI), smoke, physical activity, and diet] may impact on specific cytokine levels in a healthy population. In total, 150 healthy volunteers were recruited and subjected to questionnaires about the last 7-day lifestyle, including smoking habit, physical activity, and food frequency. A panel of circulating cytokines, chemokines, and growth factors was analyzed by multiplex ELISA. BMI showed the heaviest impact on the correlation between LGCI-related risk factors and cytokines and was significantly associated with CRP levels. Aging was characterized by an increase in IL-1b, eotaxin, MCP-1, and MIP-1α. Smoking was related to higher levels of IL-1b and CCL5/RANTES, while physical activity was related to MIP-1α. Within the different eating habits, CRP levels were modulated by eggs, red meat, shelled fruits, and greens consumption; however, these associations were not confirmed in a multivariate model after adjusting for BMI. Nevertheless, red meat consumption was associated with an inflammatory pattern, characterized by an increase in IL-6 and IL-8. IL-8 levels were also increased with the frequent intake of sweets, while a higher intake of shelled fruits correlated with lower levels of IL-6. Moreover, IL-6 and IL-8 formed a cluster that also included IL-1b and TNF-α. In conclusion, age, BMI, smoke, physical activity, and dietary habits are associated with specific cytokines that may represent potential markers for LGCI. |
| first_indexed | 2024-12-12T15:28:19Z |
| format | Article |
| id | doaj.art-c63bb26be87a410c8a82758997e3f067 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-12-12T15:28:19Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-c63bb26be87a410c8a82758997e3f0672022-12-22T00:20:11ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-06-01910.3389/fnut.2022.913176913176Lifestyle and Dietary Habits Affect Plasma Levels of Specific Cytokines in Healthy SubjectsVittoria D'Esposito0Vittoria D'Esposito1Michele Francesco Di Tolla2Manuela Lecce3Francesco Cavalli4Michele Libutti5Saverio Misso6Serena Cabaro7Serena Cabaro8Maria Rosaria Ambrosio9Maria Rosaria Ambrosio10Alessia Parascandolo11Bianca Covelli12Giuseppe Perruolo13Mario Sansone14Pietro Formisano15Pietro Formisano16URT “Genomic of Diabetes”, Institute of Experimental Endocrinology and Oncology (IEOS), National Research Council (CNR), Naples, ItalyDepartment of Translational Medical Sciences, University of Naples “Federico II”, Naples, ItalyDepartment of Translational Medical Sciences, University of Naples “Federico II”, Naples, ItalyDepartment of Translational Medical Sciences, University of Naples “Federico II”, Naples, ItalyThe Anti-inflammaging Company AG, Zurich, SwitzerlandOncology Department, Azienda Sanitaria Locale Napoli 3 Sud, Naples, ItalyUnit of Transfusion Medicine, Azienda Sanitaria Locale Caserta, Caserta, ItalyURT “Genomic of Diabetes”, Institute of Experimental Endocrinology and Oncology (IEOS), National Research Council (CNR), Naples, ItalyDepartment of Translational Medical Sciences, University of Naples “Federico II”, Naples, ItalyURT “Genomic of Diabetes”, Institute of Experimental Endocrinology and Oncology (IEOS), National Research Council (CNR), Naples, ItalyDepartment of Translational Medical Sciences, University of Naples “Federico II”, Naples, ItalyDepartment of Translational Medical Sciences, University of Naples “Federico II”, Naples, ItalyDepartment of Translational Medical Sciences, University of Naples “Federico II”, Naples, ItalyDepartment of Translational Medical Sciences, University of Naples “Federico II”, Naples, ItalyDepartment of Electrical Engineering and Information Technology, Polytechnic and Basic Sciences School, University of Naples Federico II, Naples, ItalyURT “Genomic of Diabetes”, Institute of Experimental Endocrinology and Oncology (IEOS), National Research Council (CNR), Naples, ItalyDepartment of Translational Medical Sciences, University of Naples “Federico II”, Naples, ItalyLow-grade chronic inflammation (LGCI) is a common feature of non-communicable diseases. Cytokines play a crucial role in LGCI. This study aimed to assess how LGCI risk factors [e.g., age, body mass index (BMI), smoke, physical activity, and diet] may impact on specific cytokine levels in a healthy population. In total, 150 healthy volunteers were recruited and subjected to questionnaires about the last 7-day lifestyle, including smoking habit, physical activity, and food frequency. A panel of circulating cytokines, chemokines, and growth factors was analyzed by multiplex ELISA. BMI showed the heaviest impact on the correlation between LGCI-related risk factors and cytokines and was significantly associated with CRP levels. Aging was characterized by an increase in IL-1b, eotaxin, MCP-1, and MIP-1α. Smoking was related to higher levels of IL-1b and CCL5/RANTES, while physical activity was related to MIP-1α. Within the different eating habits, CRP levels were modulated by eggs, red meat, shelled fruits, and greens consumption; however, these associations were not confirmed in a multivariate model after adjusting for BMI. Nevertheless, red meat consumption was associated with an inflammatory pattern, characterized by an increase in IL-6 and IL-8. IL-8 levels were also increased with the frequent intake of sweets, while a higher intake of shelled fruits correlated with lower levels of IL-6. Moreover, IL-6 and IL-8 formed a cluster that also included IL-1b and TNF-α. In conclusion, age, BMI, smoke, physical activity, and dietary habits are associated with specific cytokines that may represent potential markers for LGCI.https://www.frontiersin.org/articles/10.3389/fnut.2022.913176/fullcytokineslow-grade chronic inflammationbiomarkersbody mass indexinflammaging |
| spellingShingle | Vittoria D'Esposito Vittoria D'Esposito Michele Francesco Di Tolla Manuela Lecce Francesco Cavalli Michele Libutti Saverio Misso Serena Cabaro Serena Cabaro Maria Rosaria Ambrosio Maria Rosaria Ambrosio Alessia Parascandolo Bianca Covelli Giuseppe Perruolo Mario Sansone Pietro Formisano Pietro Formisano Lifestyle and Dietary Habits Affect Plasma Levels of Specific Cytokines in Healthy Subjects Frontiers in Nutrition cytokines low-grade chronic inflammation biomarkers body mass index inflammaging |
| title | Lifestyle and Dietary Habits Affect Plasma Levels of Specific Cytokines in Healthy Subjects |
| title_full | Lifestyle and Dietary Habits Affect Plasma Levels of Specific Cytokines in Healthy Subjects |
| title_fullStr | Lifestyle and Dietary Habits Affect Plasma Levels of Specific Cytokines in Healthy Subjects |
| title_full_unstemmed | Lifestyle and Dietary Habits Affect Plasma Levels of Specific Cytokines in Healthy Subjects |
| title_short | Lifestyle and Dietary Habits Affect Plasma Levels of Specific Cytokines in Healthy Subjects |
| title_sort | lifestyle and dietary habits affect plasma levels of specific cytokines in healthy subjects |
| topic | cytokines low-grade chronic inflammation biomarkers body mass index inflammaging |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.913176/full |
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