Modulating protein quality control
Small molecules that modulate the unfolded protein response have the potential to treat a variety of human protein misfolding diseases.
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
eLife Sciences Publications Ltd
2016-07-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/18431 |
| _version_ | 1818019653264343040 |
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| author | Lars Plate Ryan J Paxman R Luke Wiseman Jeffery W Kelly |
| author_facet | Lars Plate Ryan J Paxman R Luke Wiseman Jeffery W Kelly |
| author_sort | Lars Plate |
| collection | DOAJ |
| description | Small molecules that modulate the unfolded protein response have the potential to treat a variety of human protein misfolding diseases. |
| first_indexed | 2024-04-14T07:55:05Z |
| format | Article |
| id | doaj.art-c63fb05023cb44e1b3cc465198ad0e7d |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-14T07:55:05Z |
| publishDate | 2016-07-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-c63fb05023cb44e1b3cc465198ad0e7d2022-12-22T02:05:05ZengeLife Sciences Publications LtdeLife2050-084X2016-07-01510.7554/eLife.18431Modulating protein quality controlLars Plate0https://orcid.org/0000-0003-4363-6116Ryan J Paxman1https://orcid.org/0000-0001-6421-1892R Luke Wiseman2https://orcid.org/0000-0001-9287-6840Jeffery W Kelly3Department of Chemistry, The Scripps Research Institute, La Jolla, United States; Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, United StatesDepartment of Chemistry, The Scripps Research Institute, La Jolla, United StatesDepartment of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, United States; Department of Chemical Physiology, The Scripps Research Institute, La Jolla, United StatesDepartment of Chemistry, The Scripps Research Institute, La Jolla, United States; Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, United StatesSmall molecules that modulate the unfolded protein response have the potential to treat a variety of human protein misfolding diseases.https://elifesciences.org/articles/18431endoplasmic reticulumunfolded protein responsesmall molecule screeningATF6-alphaER stresssite-1-protease |
| spellingShingle | Lars Plate Ryan J Paxman R Luke Wiseman Jeffery W Kelly Modulating protein quality control eLife endoplasmic reticulum unfolded protein response small molecule screening ATF6-alpha ER stress site-1-protease |
| title | Modulating protein quality control |
| title_full | Modulating protein quality control |
| title_fullStr | Modulating protein quality control |
| title_full_unstemmed | Modulating protein quality control |
| title_short | Modulating protein quality control |
| title_sort | modulating protein quality control |
| topic | endoplasmic reticulum unfolded protein response small molecule screening ATF6-alpha ER stress site-1-protease |
| url | https://elifesciences.org/articles/18431 |
| work_keys_str_mv | AT larsplate modulatingproteinqualitycontrol AT ryanjpaxman modulatingproteinqualitycontrol AT rlukewiseman modulatingproteinqualitycontrol AT jefferywkelly modulatingproteinqualitycontrol |