Discovery of novel and potent CDK8 inhibitors for the treatment of acute myeloid leukaemia

Discovery of novel and potent CDK8 inhibitors for the treatment of acute myeloid leukaemia

It has been reported that CDK8 plays a key role in acute myeloid leukaemia. Here, a total of 40 compounds were rational designed and synthesised based on the previous SAR. Among them, compound 12 (3-(3-(furan-3-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)benzamide) showed the most potent inhibiting activity a...

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Bibliographic Details
Main Authors: Zhuoying Chen, Quan Wang, Yao Yao Yan, Dalong Jin, Yumeng Wang, Xing Xing Zhang, Xin Hua Liu
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
CDK8 inhibitor
STAT-1
STAT-5
AML
Online Access:https://www.tandfonline.com/doi/10.1080/14756366.2024.2305852

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