Clinical symptom profile of hospitalized COVID-19 Brazilian patients according to SARS-CoV-2 variants
OBJECTIVES The aim of this study was to investigate the prevalence of the main symptoms in Brazilian coronavirus disease 2019 (COVID-19) patients hospitalized during 4 distinct waves, based on their infection with different severe acute respiratory disease coronavirus 2 (SARS-CoV-2) variants. METHOD...
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| Format: | Article |
| Language: | English |
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Korean Society of Epidemiology
2023-08-01
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| Series: | Epidemiology and Health |
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| Online Access: | http://www.e-epih.org/upload/epih-45-e2023079.pdf |
| _version_ | 1797305319935705088 |
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| author | Natália Satchiko Hojo-Souza Vander Luis de Souza Freitas Daniel Ludovico Guidoni Fernanda Sumika Hojo de Souza |
| author_facet | Natália Satchiko Hojo-Souza Vander Luis de Souza Freitas Daniel Ludovico Guidoni Fernanda Sumika Hojo de Souza |
| author_sort | Natália Satchiko Hojo-Souza |
| collection | DOAJ |
| description | OBJECTIVES The aim of this study was to investigate the prevalence of the main symptoms in Brazilian coronavirus disease 2019 (COVID-19) patients hospitalized during 4 distinct waves, based on their infection with different severe acute respiratory disease coronavirus 2 (SARS-CoV-2) variants. METHODS This study included hospitalized patients who tested positive for SARS-CoV-2 during 15 weeks around the peak of each of 4 waves: W1, ancestral strain/B.1 lineage (May 31 to September 12, 2020); W2, Gamma/P.1 variant (January 31 to May 15, 2021); W3, Omicron variant (December 5, 2021 to March 19, 2022); and W4, BA.4/BA.5 subvariants (May 22 to September 3, 2022). Symptom data were extracted from the Brazilian Severe Acute Respiratory Syndrome Database. Relative risks were calculated, and an analysis of symptom networks was performed. RESULTS Patients who were hospitalized during the prevalence of the Gamma/P.1 variant demonstrated a higher risk, primarily for symptoms such as fatigue, abdominal pain, low oxygen saturation, and sore throat, than patients hospitalized during the first wave. Conversely, patients who were hospitalized during the predominance of the Omicron variant exhibited a lower relative risk, particularly for symptoms such as loss of smell, loss of taste, diarrhea, fever, respiratory distress, and dyspnea. Similar results were observed in COVID-19 patients who were hospitalized during the wave of the Omicron subvariants BA.4/BA.5. A symptom network analysis, conducted to explore co-occurrence patterns among different variants, revealed significant differential profiles across the 4 waves, with the most notable difference observed between the W2 and W4 networks. CONCLUSIONS Overall, the relative risks and patterns of symptom co-occurrence associated with different SARS-CoV-2 variants may reflect disease severity. |
| first_indexed | 2024-03-08T00:24:12Z |
| format | Article |
| id | doaj.art-c6441fba48ae43caa312f243600429c9 |
| institution | Directory Open Access Journal |
| issn | 2092-7193 |
| language | English |
| last_indexed | 2024-03-08T00:24:12Z |
| publishDate | 2023-08-01 |
| publisher | Korean Society of Epidemiology |
| record_format | Article |
| series | Epidemiology and Health |
| spelling | doaj.art-c6441fba48ae43caa312f243600429c92024-02-16T01:04:25ZengKorean Society of EpidemiologyEpidemiology and Health2092-71932023-08-014510.4178/epih.e20230791442Clinical symptom profile of hospitalized COVID-19 Brazilian patients according to SARS-CoV-2 variantsNatália Satchiko Hojo-Souza0Vander Luis de Souza Freitas1Daniel Ludovico Guidoni2Fernanda Sumika Hojo de Souza3 Laboratory of Immunopathology, René Rachou Institute, Oswaldo Cruz Foundation, Belo Horizonte, Brazil Department of Computing, Federal University of Ouro Preto, Ouro Preto, Brazil Department of Computing, Federal University of Ouro Preto, Ouro Preto, Brazil Department of Computing, Federal University of Ouro Preto, Ouro Preto, BrazilOBJECTIVES The aim of this study was to investigate the prevalence of the main symptoms in Brazilian coronavirus disease 2019 (COVID-19) patients hospitalized during 4 distinct waves, based on their infection with different severe acute respiratory disease coronavirus 2 (SARS-CoV-2) variants. METHODS This study included hospitalized patients who tested positive for SARS-CoV-2 during 15 weeks around the peak of each of 4 waves: W1, ancestral strain/B.1 lineage (May 31 to September 12, 2020); W2, Gamma/P.1 variant (January 31 to May 15, 2021); W3, Omicron variant (December 5, 2021 to March 19, 2022); and W4, BA.4/BA.5 subvariants (May 22 to September 3, 2022). Symptom data were extracted from the Brazilian Severe Acute Respiratory Syndrome Database. Relative risks were calculated, and an analysis of symptom networks was performed. RESULTS Patients who were hospitalized during the prevalence of the Gamma/P.1 variant demonstrated a higher risk, primarily for symptoms such as fatigue, abdominal pain, low oxygen saturation, and sore throat, than patients hospitalized during the first wave. Conversely, patients who were hospitalized during the predominance of the Omicron variant exhibited a lower relative risk, particularly for symptoms such as loss of smell, loss of taste, diarrhea, fever, respiratory distress, and dyspnea. Similar results were observed in COVID-19 patients who were hospitalized during the wave of the Omicron subvariants BA.4/BA.5. A symptom network analysis, conducted to explore co-occurrence patterns among different variants, revealed significant differential profiles across the 4 waves, with the most notable difference observed between the W2 and W4 networks. CONCLUSIONS Overall, the relative risks and patterns of symptom co-occurrence associated with different SARS-CoV-2 variants may reflect disease severity.http://www.e-epih.org/upload/epih-45-e2023079.pdfcovid-19symptom assessmentsars-cov-2 variantsdisease outbreaksbrazil |
| spellingShingle | Natália Satchiko Hojo-Souza Vander Luis de Souza Freitas Daniel Ludovico Guidoni Fernanda Sumika Hojo de Souza Clinical symptom profile of hospitalized COVID-19 Brazilian patients according to SARS-CoV-2 variants Epidemiology and Health covid-19 symptom assessment sars-cov-2 variants disease outbreaks brazil |
| title | Clinical symptom profile of hospitalized COVID-19 Brazilian patients according to SARS-CoV-2 variants |
| title_full | Clinical symptom profile of hospitalized COVID-19 Brazilian patients according to SARS-CoV-2 variants |
| title_fullStr | Clinical symptom profile of hospitalized COVID-19 Brazilian patients according to SARS-CoV-2 variants |
| title_full_unstemmed | Clinical symptom profile of hospitalized COVID-19 Brazilian patients according to SARS-CoV-2 variants |
| title_short | Clinical symptom profile of hospitalized COVID-19 Brazilian patients according to SARS-CoV-2 variants |
| title_sort | clinical symptom profile of hospitalized covid 19 brazilian patients according to sars cov 2 variants |
| topic | covid-19 symptom assessment sars-cov-2 variants disease outbreaks brazil |
| url | http://www.e-epih.org/upload/epih-45-e2023079.pdf |
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