OCT Imaging in Murine Models of Alzheimer’s Disease in a Systematic Review: Findings, Methodology and Future Perspectives
The murine models of Alzheimer’s disease (AD) have advanced our understanding of the pathophysiology. In vivo studies of the retina using optical coherence tomography (OCT) have complemented histological methods; however, the lack of standardisation in OCT methodologies for murine models of AD has l...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/12/3/528 |
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| author | Lidia Sánchez-Puebla Inés López-Cuenca Elena Salobrar-García Ana I. Ramírez José A. Fernández-Albarral José A. Matamoros Lorena Elvira-Hurtado Juan J. Salazar José M. Ramírez Rosa de Hoz |
| author_facet | Lidia Sánchez-Puebla Inés López-Cuenca Elena Salobrar-García Ana I. Ramírez José A. Fernández-Albarral José A. Matamoros Lorena Elvira-Hurtado Juan J. Salazar José M. Ramírez Rosa de Hoz |
| author_sort | Lidia Sánchez-Puebla |
| collection | DOAJ |
| description | The murine models of Alzheimer’s disease (AD) have advanced our understanding of the pathophysiology. In vivo studies of the retina using optical coherence tomography (OCT) have complemented histological methods; however, the lack of standardisation in OCT methodologies for murine models of AD has led to significant variations in the results of different studies. A literature search in PubMed and Scopus has been performed to review the different methods used in these models using OCT and to analyse the methodological characteristics of each study. In addition, some recommendations are offered to overcome the challenges of using OCT in murine models. The results reveal a lack of consensus on OCT device use, retinal area analysed, segmentation techniques, and analysis software. Although some studies use the same OCT device, variations in other parameters make the direct comparison of results difficult. Standardisation of retinal analysis criteria in murine models of AD using OCT is crucial to ensure consistent and comparable results. This implies the application of uniform measurement and segmentation protocols. Despite the absence of standardisation, OCT has proven valuable in advancing our understanding of the pathophysiology of AD. |
| first_indexed | 2024-04-24T18:31:37Z |
| format | Article |
| id | doaj.art-c6443dfe95444bb396119ce09df80050 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-04-24T18:31:37Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-c6443dfe95444bb396119ce09df800502024-03-27T13:22:42ZengMDPI AGBiomedicines2227-90592024-02-0112352810.3390/biomedicines12030528OCT Imaging in Murine Models of Alzheimer’s Disease in a Systematic Review: Findings, Methodology and Future PerspectivesLidia Sánchez-Puebla0Inés López-Cuenca1Elena Salobrar-García2Ana I. Ramírez3José A. Fernández-Albarral4José A. Matamoros5Lorena Elvira-Hurtado6Juan J. Salazar7José M. Ramírez8Rosa de Hoz9Ramon Castroviejo Institute for Ophthalmic Research, Complutense University of Madrid, 28040 Madrid, SpainRamon Castroviejo Institute for Ophthalmic Research, Complutense University of Madrid, 28040 Madrid, SpainRamon Castroviejo Institute for Ophthalmic Research, Complutense University of Madrid, 28040 Madrid, SpainRamon Castroviejo Institute for Ophthalmic Research, Complutense University of Madrid, 28040 Madrid, SpainRamon Castroviejo Institute for Ophthalmic Research, Complutense University of Madrid, 28040 Madrid, SpainRamon Castroviejo Institute for Ophthalmic Research, Complutense University of Madrid, 28040 Madrid, SpainRamon Castroviejo Institute for Ophthalmic Research, Complutense University of Madrid, 28040 Madrid, SpainRamon Castroviejo Institute for Ophthalmic Research, Complutense University of Madrid, 28040 Madrid, SpainRamon Castroviejo Institute for Ophthalmic Research, Complutense University of Madrid, 28040 Madrid, SpainRamon Castroviejo Institute for Ophthalmic Research, Complutense University of Madrid, 28040 Madrid, SpainThe murine models of Alzheimer’s disease (AD) have advanced our understanding of the pathophysiology. In vivo studies of the retina using optical coherence tomography (OCT) have complemented histological methods; however, the lack of standardisation in OCT methodologies for murine models of AD has led to significant variations in the results of different studies. A literature search in PubMed and Scopus has been performed to review the different methods used in these models using OCT and to analyse the methodological characteristics of each study. In addition, some recommendations are offered to overcome the challenges of using OCT in murine models. The results reveal a lack of consensus on OCT device use, retinal area analysed, segmentation techniques, and analysis software. Although some studies use the same OCT device, variations in other parameters make the direct comparison of results difficult. Standardisation of retinal analysis criteria in murine models of AD using OCT is crucial to ensure consistent and comparable results. This implies the application of uniform measurement and segmentation protocols. Despite the absence of standardisation, OCT has proven valuable in advancing our understanding of the pathophysiology of AD.https://www.mdpi.com/2227-9059/12/3/528Alzheimer’s diseaseAD mouse modeloptical coherence tomographyretina |
| spellingShingle | Lidia Sánchez-Puebla Inés López-Cuenca Elena Salobrar-García Ana I. Ramírez José A. Fernández-Albarral José A. Matamoros Lorena Elvira-Hurtado Juan J. Salazar José M. Ramírez Rosa de Hoz OCT Imaging in Murine Models of Alzheimer’s Disease in a Systematic Review: Findings, Methodology and Future Perspectives Biomedicines Alzheimer’s disease AD mouse model optical coherence tomography retina |
| title | OCT Imaging in Murine Models of Alzheimer’s Disease in a Systematic Review: Findings, Methodology and Future Perspectives |
| title_full | OCT Imaging in Murine Models of Alzheimer’s Disease in a Systematic Review: Findings, Methodology and Future Perspectives |
| title_fullStr | OCT Imaging in Murine Models of Alzheimer’s Disease in a Systematic Review: Findings, Methodology and Future Perspectives |
| title_full_unstemmed | OCT Imaging in Murine Models of Alzheimer’s Disease in a Systematic Review: Findings, Methodology and Future Perspectives |
| title_short | OCT Imaging in Murine Models of Alzheimer’s Disease in a Systematic Review: Findings, Methodology and Future Perspectives |
| title_sort | oct imaging in murine models of alzheimer s disease in a systematic review findings methodology and future perspectives |
| topic | Alzheimer’s disease AD mouse model optical coherence tomography retina |
| url | https://www.mdpi.com/2227-9059/12/3/528 |
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