Evaluation of the Anti-Obesity Effect of Zeaxanthin and Exercise in HFD-Induced Obese Rats
Obesity is a worldwide epidemic associated with many health problems. One of the new trends in health care is the emphasis on regular exercise and a healthy diet. Zeaxanthin (Zea) is a carotenoid with many beneficial effects on human health. The aim of this study was to investigate whether the combi...
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MDPI AG
2022-11-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/23/4944 |
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| author | Mona Al-thepyani Salha Algarni Hana Gashlan Mohamed Elzubier Lina Baz |
| author_facet | Mona Al-thepyani Salha Algarni Hana Gashlan Mohamed Elzubier Lina Baz |
| author_sort | Mona Al-thepyani |
| collection | DOAJ |
| description | Obesity is a worldwide epidemic associated with many health problems. One of the new trends in health care is the emphasis on regular exercise and a healthy diet. Zeaxanthin (Zea) is a carotenoid with many beneficial effects on human health. The aim of this study was to investigate whether the combination of Zea and exercise had therapeutic effects on obesity induced by an HFD in rats. Sixty male Wistar rats were randomly divided into five groups of twelve: rats fed a standard diet; rats fed a high-fat diet (HFD); rats fed an HFD with Zea; rats fed an HFD with Exc; and rats fed an HFD with both Zea and Exc. To induce obesity, rats were fed an HFD for twelve weeks. Then, Zea and exercise were introduced with the HFD for five weeks. The results showed that the HFD significantly increased visceral adipose tissue, oxidative stress, and inflammation biomarkers and reduced insulin, high-density lipoprotein, and antioxidant parameters. Treatments with Zea, Exc, and Zea plus Exc reduced body weight gain, triacylglycerol, glucose, total cholesterol, and nitric oxide levels and significantly increased catalase and insulin compared with the HFD group. This study demonstrated that Zea administration and Exc performance appeared to effectively alleviate the metabolic alterations induced by an HFD. Furthermore, Zea and Exc together had a better effect than either intervention alone. |
| first_indexed | 2024-03-09T17:38:02Z |
| format | Article |
| id | doaj.art-c64489df896e4538b3a64c2f4d14de45 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T17:38:02Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-c64489df896e4538b3a64c2f4d14de452023-11-24T11:49:33ZengMDPI AGNutrients2072-66432022-11-011423494410.3390/nu14234944Evaluation of the Anti-Obesity Effect of Zeaxanthin and Exercise in HFD-Induced Obese RatsMona Al-thepyani0Salha Algarni1Hana Gashlan2Mohamed Elzubier3Lina Baz4Department of Biochemistry, Faculty of Science, King AbdulAziz University, Jeddah 21589, Saudi ArabiaDepartment of Biochemistry, Faculty of Science, King AbdulAziz University, Jeddah 21589, Saudi ArabiaDepartment of Biochemistry, Faculty of Science, King AbdulAziz University, Jeddah 21589, Saudi ArabiaBiochemistry Department, Faculty of Medicine, Umm Al-Qura University, Al Abdeyah, Makkah P.O. Box 7607, Saudi ArabiaDepartment of Biochemistry, Faculty of Science, King AbdulAziz University, Jeddah 21589, Saudi ArabiaObesity is a worldwide epidemic associated with many health problems. One of the new trends in health care is the emphasis on regular exercise and a healthy diet. Zeaxanthin (Zea) is a carotenoid with many beneficial effects on human health. The aim of this study was to investigate whether the combination of Zea and exercise had therapeutic effects on obesity induced by an HFD in rats. Sixty male Wistar rats were randomly divided into five groups of twelve: rats fed a standard diet; rats fed a high-fat diet (HFD); rats fed an HFD with Zea; rats fed an HFD with Exc; and rats fed an HFD with both Zea and Exc. To induce obesity, rats were fed an HFD for twelve weeks. Then, Zea and exercise were introduced with the HFD for five weeks. The results showed that the HFD significantly increased visceral adipose tissue, oxidative stress, and inflammation biomarkers and reduced insulin, high-density lipoprotein, and antioxidant parameters. Treatments with Zea, Exc, and Zea plus Exc reduced body weight gain, triacylglycerol, glucose, total cholesterol, and nitric oxide levels and significantly increased catalase and insulin compared with the HFD group. This study demonstrated that Zea administration and Exc performance appeared to effectively alleviate the metabolic alterations induced by an HFD. Furthermore, Zea and Exc together had a better effect than either intervention alone.https://www.mdpi.com/2072-6643/14/23/4944zeaxanthinexerciseswimminganti-obesityhigh-fat dietantioxidants |
| spellingShingle | Mona Al-thepyani Salha Algarni Hana Gashlan Mohamed Elzubier Lina Baz Evaluation of the Anti-Obesity Effect of Zeaxanthin and Exercise in HFD-Induced Obese Rats Nutrients zeaxanthin exercise swimming anti-obesity high-fat diet antioxidants |
| title | Evaluation of the Anti-Obesity Effect of Zeaxanthin and Exercise in HFD-Induced Obese Rats |
| title_full | Evaluation of the Anti-Obesity Effect of Zeaxanthin and Exercise in HFD-Induced Obese Rats |
| title_fullStr | Evaluation of the Anti-Obesity Effect of Zeaxanthin and Exercise in HFD-Induced Obese Rats |
| title_full_unstemmed | Evaluation of the Anti-Obesity Effect of Zeaxanthin and Exercise in HFD-Induced Obese Rats |
| title_short | Evaluation of the Anti-Obesity Effect of Zeaxanthin and Exercise in HFD-Induced Obese Rats |
| title_sort | evaluation of the anti obesity effect of zeaxanthin and exercise in hfd induced obese rats |
| topic | zeaxanthin exercise swimming anti-obesity high-fat diet antioxidants |
| url | https://www.mdpi.com/2072-6643/14/23/4944 |
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