Complex II Biology in Aging, Health, and Disease
Aging is associated with a decline in mitochondrial function which may contribute to age-related diseases such as neurodegeneration, cancer, and cardiovascular diseases. Recently, mitochondrial Complex II has emerged as an important player in the aging process. Mitochondrial Complex II converts succ...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-07-01
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| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/12/7/1477 |
| _version_ | 1827734191181135872 |
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| author | Eric Goetzman Zhenwei Gong Bob Zhang Radhika Muzumdar |
| author_facet | Eric Goetzman Zhenwei Gong Bob Zhang Radhika Muzumdar |
| author_sort | Eric Goetzman |
| collection | DOAJ |
| description | Aging is associated with a decline in mitochondrial function which may contribute to age-related diseases such as neurodegeneration, cancer, and cardiovascular diseases. Recently, mitochondrial Complex II has emerged as an important player in the aging process. Mitochondrial Complex II converts succinate to fumarate and plays an essential role in both the tricarboxylic acid (TCA) cycle and the electron transport chain (ETC). The dysfunction of Complex II not only limits mitochondrial energy production; it may also promote oxidative stress, contributing, over time, to cellular damage, aging, and disease. Intriguingly, succinate, the substrate for Complex II which accumulates during mitochondrial dysfunction, has been shown to have widespread effects as a signaling molecule. Here, we review recent advances related to understanding the function of Complex II, succinate signaling, and their combined roles in aging and aging-related diseases. |
| first_indexed | 2024-03-11T01:21:56Z |
| format | Article |
| id | doaj.art-c6450af13088451c930e796a497a8122 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-11T01:21:56Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-c6450af13088451c930e796a497a81222023-11-18T18:06:33ZengMDPI AGAntioxidants2076-39212023-07-01127147710.3390/antiox12071477Complex II Biology in Aging, Health, and DiseaseEric Goetzman0Zhenwei Gong1Bob Zhang2Radhika Muzumdar3Division of Genetic and Genomic Medicine, Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA 15260, USADivision of Endocrinology, Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA 15260, USADivision of Genetic and Genomic Medicine, Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA 15260, USADivision of Endocrinology, Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA 15260, USAAging is associated with a decline in mitochondrial function which may contribute to age-related diseases such as neurodegeneration, cancer, and cardiovascular diseases. Recently, mitochondrial Complex II has emerged as an important player in the aging process. Mitochondrial Complex II converts succinate to fumarate and plays an essential role in both the tricarboxylic acid (TCA) cycle and the electron transport chain (ETC). The dysfunction of Complex II not only limits mitochondrial energy production; it may also promote oxidative stress, contributing, over time, to cellular damage, aging, and disease. Intriguingly, succinate, the substrate for Complex II which accumulates during mitochondrial dysfunction, has been shown to have widespread effects as a signaling molecule. Here, we review recent advances related to understanding the function of Complex II, succinate signaling, and their combined roles in aging and aging-related diseases.https://www.mdpi.com/2076-3921/12/7/1477agingComplex IIsuccinate dehydrogenasereactive oxygen species |
| spellingShingle | Eric Goetzman Zhenwei Gong Bob Zhang Radhika Muzumdar Complex II Biology in Aging, Health, and Disease Antioxidants aging Complex II succinate dehydrogenase reactive oxygen species |
| title | Complex II Biology in Aging, Health, and Disease |
| title_full | Complex II Biology in Aging, Health, and Disease |
| title_fullStr | Complex II Biology in Aging, Health, and Disease |
| title_full_unstemmed | Complex II Biology in Aging, Health, and Disease |
| title_short | Complex II Biology in Aging, Health, and Disease |
| title_sort | complex ii biology in aging health and disease |
| topic | aging Complex II succinate dehydrogenase reactive oxygen species |
| url | https://www.mdpi.com/2076-3921/12/7/1477 |
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