Exogenous H2S initiating Nrf2/GPx4/GSH pathway through promoting Syvn1-Keap1 interaction in diabetic hearts

Exogenous H2S initiating Nrf2/GPx4/GSH pathway through promoting Syvn1-Keap1 interaction in diabetic hearts

Abstract Excessive ROS accumulation contributes to cardiac injury in type 2 diabetes mellitus. Hydrogen sulfide (H2S) is a vital endogenous gasotransmitter to alleviate cardiac damage in diabetic cardiomyopathy (DCM). However, the underlying mechanisms remain unclear. In this study, we investigated...

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Bibliographic Details
Main Authors: Mengyi Wang, Jingyuan Tang, Shiwu Zhang, Kemiao Pang, Yajun Zhao, Ning Liu, Jiayi Huang, Jiaxin Kang, Shiyun Dong, Hongxia Li, Zhen Tian, Binhong Duan, Fanghao Lu, Weihua Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2023-10-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-023-01690-w

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