SARS-CoV-2 Delta Variant Pathogenesis and Host Response in Syrian Hamsters
B.1.617 is becoming a dominant Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) lineage worldwide with many sublineages, of which B.1.617.2 is designated as a variant of concern. The pathogenicity of B.1.617.2 (Delta) and B.1.617.3 lineage of SARS-CoV-2 was evaluated and compared with th...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/13/9/1773 |
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| author | Sreelekshmy Mohandas Pragya Dhruv Yadav Anita Shete Dimpal Nyayanit Gajanan Sapkal Kavita Lole Nivedita Gupta |
| author_facet | Sreelekshmy Mohandas Pragya Dhruv Yadav Anita Shete Dimpal Nyayanit Gajanan Sapkal Kavita Lole Nivedita Gupta |
| author_sort | Sreelekshmy Mohandas |
| collection | DOAJ |
| description | B.1.617 is becoming a dominant Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) lineage worldwide with many sublineages, of which B.1.617.2 is designated as a variant of concern. The pathogenicity of B.1.617.2 (Delta) and B.1.617.3 lineage of SARS-CoV-2 was evaluated and compared with that of B.1, an early virus isolate with D614G mutation in a Syrian hamster model. Viral load, antibody response, and lung disease were studied. There was no significant difference in the virus shedding pattern among these variants. High levels of SARS-CoV-2 sub genomic RNA were detected in the respiratory tract of hamsters infected with the Delta variant for 14 days, which warrants further transmission studies. The Delta variant induced lung disease of moderate severity in about 40% of infected animals, which supports the attributed disease severity of the variant. Cross neutralizing antibodies were detected in animals infected with B.1, Delta, and B.1.617.3 variant, but neutralizing capacity was significantly lower with B.1.351 (Beta variant). |
| first_indexed | 2024-03-10T07:09:01Z |
| format | Article |
| id | doaj.art-c650ca2143784cfd82492ff494d28348 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T07:09:01Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-c650ca2143784cfd82492ff494d283482023-11-22T15:37:45ZengMDPI AGViruses1999-49152021-09-01139177310.3390/v13091773SARS-CoV-2 Delta Variant Pathogenesis and Host Response in Syrian HamstersSreelekshmy Mohandas0Pragya Dhruv Yadav1Anita Shete2Dimpal Nyayanit3Gajanan Sapkal4Kavita Lole5Nivedita Gupta6Indian Council of Medical Research-National Institute of Virology, Pune 411021, IndiaIndian Council of Medical Research-National Institute of Virology, Pune 411021, IndiaIndian Council of Medical Research-National Institute of Virology, Pune 411021, IndiaIndian Council of Medical Research-National Institute of Virology, Pune 411021, IndiaIndian Council of Medical Research-National Institute of Virology, Pune 411021, IndiaIndian Council of Medical Research-National Institute of Virology, Pune 411021, IndiaIndian Council of Medical Research, V. Ramalingaswami Bhawan, P.O. Box No. 4911, Ansari Nagar, New Delhi 110029, IndiaB.1.617 is becoming a dominant Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) lineage worldwide with many sublineages, of which B.1.617.2 is designated as a variant of concern. The pathogenicity of B.1.617.2 (Delta) and B.1.617.3 lineage of SARS-CoV-2 was evaluated and compared with that of B.1, an early virus isolate with D614G mutation in a Syrian hamster model. Viral load, antibody response, and lung disease were studied. There was no significant difference in the virus shedding pattern among these variants. High levels of SARS-CoV-2 sub genomic RNA were detected in the respiratory tract of hamsters infected with the Delta variant for 14 days, which warrants further transmission studies. The Delta variant induced lung disease of moderate severity in about 40% of infected animals, which supports the attributed disease severity of the variant. Cross neutralizing antibodies were detected in animals infected with B.1, Delta, and B.1.617.3 variant, but neutralizing capacity was significantly lower with B.1.351 (Beta variant).https://www.mdpi.com/1999-4915/13/9/1773SARS-CoV-2Delta variantB.1.617.2B.1.617.3Syrian hamsterpathogenicity |
| spellingShingle | Sreelekshmy Mohandas Pragya Dhruv Yadav Anita Shete Dimpal Nyayanit Gajanan Sapkal Kavita Lole Nivedita Gupta SARS-CoV-2 Delta Variant Pathogenesis and Host Response in Syrian Hamsters Viruses SARS-CoV-2 Delta variant B.1.617.2 B.1.617.3 Syrian hamster pathogenicity |
| title | SARS-CoV-2 Delta Variant Pathogenesis and Host Response in Syrian Hamsters |
| title_full | SARS-CoV-2 Delta Variant Pathogenesis and Host Response in Syrian Hamsters |
| title_fullStr | SARS-CoV-2 Delta Variant Pathogenesis and Host Response in Syrian Hamsters |
| title_full_unstemmed | SARS-CoV-2 Delta Variant Pathogenesis and Host Response in Syrian Hamsters |
| title_short | SARS-CoV-2 Delta Variant Pathogenesis and Host Response in Syrian Hamsters |
| title_sort | sars cov 2 delta variant pathogenesis and host response in syrian hamsters |
| topic | SARS-CoV-2 Delta variant B.1.617.2 B.1.617.3 Syrian hamster pathogenicity |
| url | https://www.mdpi.com/1999-4915/13/9/1773 |
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