Intramolecular C2 Domain-Mediated Autoinhibition of Protein Kinase C βII

Intramolecular C2 Domain-Mediated Autoinhibition of Protein Kinase C βII

The signaling output of protein kinase C (PKC) is exquisitely controlled, with its disruption resulting in pathophysiologies. Identifying the structural basis for autoinhibition is central to developing effective therapies for cancer, where PKC activity needs to be enhanced, or neurodegenerative dis...

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Bibliographic Details
Main Authors: Corina E. Antal, Julia A. Callender, Alexandr P. Kornev, Susan S. Taylor, Alexandra C. Newton
Format: Article
Language:English
Published: Elsevier 2015-08-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715007998

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