Mammalian microRNAs: post-transcriptional gene regulation in RNA virus infection and therapeutic applications
RNA silencing mediated by microRNAs (miRNAs) is a recently discovered gene regulatory mechanism involved in various aspects of biology, such as development, cell differentiation and proliferation, and innate immunity against viral infections. miRNAs, which are a class of small (21–25 nucleotides) RN...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2010-10-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fmicb.2010.00108/full |
| _version_ | 1818387136173309952 |
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| author | Yasuko Tsunetsugu-Yokota Takuya Yamamoto |
| author_facet | Yasuko Tsunetsugu-Yokota Takuya Yamamoto |
| author_sort | Yasuko Tsunetsugu-Yokota |
| collection | DOAJ |
| description | RNA silencing mediated by microRNAs (miRNAs) is a recently discovered gene regulatory mechanism involved in various aspects of biology, such as development, cell differentiation and proliferation, and innate immunity against viral infections. miRNAs, which are a class of small (21–25 nucleotides) RNAs, target messenger RNA (mRNA) through incomplete base-pairing with their target sequences resulting in mRNA degradation or translational repression. Although studies of miRNAs have led to numerous sensational discoveries in biology, many fundamental questions about their expression and function still remain. In this review, we discuss the dynamics of the mammalian miRNA machinery and the biological function of miRNAs, focusing on RNA viruses and the various therapeutic applications of miRNAs against viral infections. |
| first_indexed | 2024-12-14T04:05:09Z |
| format | Article |
| id | doaj.art-c6521e95b412448686bacc3ee2e16737 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-14T04:05:09Z |
| publishDate | 2010-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-c6521e95b412448686bacc3ee2e167372022-12-21T23:17:51ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2010-10-01110.3389/fmicb.2010.001082282Mammalian microRNAs: post-transcriptional gene regulation in RNA virus infection and therapeutic applicationsYasuko Tsunetsugu-Yokota0Takuya Yamamoto1National Institute of Infectious DiseasesThe Immunology Laboratory,National Institute on Alcohol Abuse and Alcoholism (NIAAA),National Institutes of HealthRNA silencing mediated by microRNAs (miRNAs) is a recently discovered gene regulatory mechanism involved in various aspects of biology, such as development, cell differentiation and proliferation, and innate immunity against viral infections. miRNAs, which are a class of small (21–25 nucleotides) RNAs, target messenger RNA (mRNA) through incomplete base-pairing with their target sequences resulting in mRNA degradation or translational repression. Although studies of miRNAs have led to numerous sensational discoveries in biology, many fundamental questions about their expression and function still remain. In this review, we discuss the dynamics of the mammalian miRNA machinery and the biological function of miRNAs, focusing on RNA viruses and the various therapeutic applications of miRNAs against viral infections.http://journal.frontiersin.org/Journal/10.3389/fmicb.2010.00108/fullGene Therapyhost-virus inetractionmammalian microRNAsRNA virus infection |
| spellingShingle | Yasuko Tsunetsugu-Yokota Takuya Yamamoto Mammalian microRNAs: post-transcriptional gene regulation in RNA virus infection and therapeutic applications Frontiers in Microbiology Gene Therapy host-virus inetraction mammalian microRNAs RNA virus infection |
| title | Mammalian microRNAs: post-transcriptional gene regulation in RNA virus infection and therapeutic applications |
| title_full | Mammalian microRNAs: post-transcriptional gene regulation in RNA virus infection and therapeutic applications |
| title_fullStr | Mammalian microRNAs: post-transcriptional gene regulation in RNA virus infection and therapeutic applications |
| title_full_unstemmed | Mammalian microRNAs: post-transcriptional gene regulation in RNA virus infection and therapeutic applications |
| title_short | Mammalian microRNAs: post-transcriptional gene regulation in RNA virus infection and therapeutic applications |
| title_sort | mammalian micrornas post transcriptional gene regulation in rna virus infection and therapeutic applications |
| topic | Gene Therapy host-virus inetraction mammalian microRNAs RNA virus infection |
| url | http://journal.frontiersin.org/Journal/10.3389/fmicb.2010.00108/full |
| work_keys_str_mv | AT yasukotsunetsuguyokota mammalianmicrornasposttranscriptionalgeneregulationinrnavirusinfectionandtherapeuticapplications AT takuyayamamoto mammalianmicrornasposttranscriptionalgeneregulationinrnavirusinfectionandtherapeuticapplications |