Kahweol Induces Apoptosis in Hepatocellular Carcinoma Cells by Inhibiting the Src/mTOR/STAT3 Signaling Pathway
Kahweol, a coffee-specific diterpene, induces apoptosis in human cancer cells, and some targets of kahweol-mediated apoptosis have been identified. However, the specific apoptotic effects and mechanism of action of kahweol in hepatocellular carcinoma (HCC) cells are unknown. This study was performed...
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MDPI AG
2021-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/19/10509 |
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| author | Hye-Young Seo So-Hee Lee Ji-Ha Lee Jae-Ho Lee Byoung Kuk Jang Mi Kyung Kim |
| author_facet | Hye-Young Seo So-Hee Lee Ji-Ha Lee Jae-Ho Lee Byoung Kuk Jang Mi Kyung Kim |
| author_sort | Hye-Young Seo |
| collection | DOAJ |
| description | Kahweol, a coffee-specific diterpene, induces apoptosis in human cancer cells, and some targets of kahweol-mediated apoptosis have been identified. However, the specific apoptotic effects and mechanism of action of kahweol in hepatocellular carcinoma (HCC) cells are unknown. This study was performed to investigate the molecular mechanism by which kahweol induces apoptosis in HCC cells. The Src pathway is associated with apoptosis in cancer. In this study, we found that kahweol induces apoptosis by inhibiting phosphorylation of Src, and also inhibiting p-mTOR and p-STAT3. Therefore, we suggest that kahweol is a potent inhibitor of HCC cell growth. |
| first_indexed | 2024-03-10T07:00:13Z |
| format | Article |
| id | doaj.art-c655b441d2e94169a09f43bb657b859f |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T07:00:13Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-c655b441d2e94169a09f43bb657b859f2023-11-22T16:11:01ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-09-0122191050910.3390/ijms221910509Kahweol Induces Apoptosis in Hepatocellular Carcinoma Cells by Inhibiting the Src/mTOR/STAT3 Signaling PathwayHye-Young Seo0So-Hee Lee1Ji-Ha Lee2Jae-Ho Lee3Byoung Kuk Jang4Mi Kyung Kim5Department of Internal Medicine, School of Medicine, Institute for Medical Science, Keimyung University, Daegu 42601, KoreaDepartment of Internal Medicine, School of Medicine, Institute for Medical Science, Keimyung University, Daegu 42601, KoreaDepartment of Internal Medicine, School of Medicine, Institute for Medical Science, Keimyung University, Daegu 42601, KoreaDepartment of Anatomy, Keimyung University School of Medicine, Dageu 42601, KoreaDepartment of Internal Medicine, School of Medicine, Institute for Medical Science, Keimyung University, Daegu 42601, KoreaDepartment of Internal Medicine, School of Medicine, Institute for Medical Science, Keimyung University, Daegu 42601, KoreaKahweol, a coffee-specific diterpene, induces apoptosis in human cancer cells, and some targets of kahweol-mediated apoptosis have been identified. However, the specific apoptotic effects and mechanism of action of kahweol in hepatocellular carcinoma (HCC) cells are unknown. This study was performed to investigate the molecular mechanism by which kahweol induces apoptosis in HCC cells. The Src pathway is associated with apoptosis in cancer. In this study, we found that kahweol induces apoptosis by inhibiting phosphorylation of Src, and also inhibiting p-mTOR and p-STAT3. Therefore, we suggest that kahweol is a potent inhibitor of HCC cell growth.https://www.mdpi.com/1422-0067/22/19/10509kahweolSrc kinaseHCCapoptosis |
| spellingShingle | Hye-Young Seo So-Hee Lee Ji-Ha Lee Jae-Ho Lee Byoung Kuk Jang Mi Kyung Kim Kahweol Induces Apoptosis in Hepatocellular Carcinoma Cells by Inhibiting the Src/mTOR/STAT3 Signaling Pathway International Journal of Molecular Sciences kahweol Src kinase HCC apoptosis |
| title | Kahweol Induces Apoptosis in Hepatocellular Carcinoma Cells by Inhibiting the Src/mTOR/STAT3 Signaling Pathway |
| title_full | Kahweol Induces Apoptosis in Hepatocellular Carcinoma Cells by Inhibiting the Src/mTOR/STAT3 Signaling Pathway |
| title_fullStr | Kahweol Induces Apoptosis in Hepatocellular Carcinoma Cells by Inhibiting the Src/mTOR/STAT3 Signaling Pathway |
| title_full_unstemmed | Kahweol Induces Apoptosis in Hepatocellular Carcinoma Cells by Inhibiting the Src/mTOR/STAT3 Signaling Pathway |
| title_short | Kahweol Induces Apoptosis in Hepatocellular Carcinoma Cells by Inhibiting the Src/mTOR/STAT3 Signaling Pathway |
| title_sort | kahweol induces apoptosis in hepatocellular carcinoma cells by inhibiting the src mtor stat3 signaling pathway |
| topic | kahweol Src kinase HCC apoptosis |
| url | https://www.mdpi.com/1422-0067/22/19/10509 |
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