Brain Delivery of Cisplatin Using Microbubbles in Combination with Ultrasound as an Effective Therapy for Glioblastoma

Brain Delivery of Cisplatin Using Microbubbles in Combination with Ultrasound as an Effective Therapy for Glioblastoma

Glioblastoma is a highly invasive and fatal disease. Temozolomide, a blood–brain barrier (BBB)-penetrant therapeutic agent currently used for glioblastoma, does not exhibit sufficient therapeutic effect. Cisplatin (CDDP), a versatile anticancer drug, is not considered a therapeutic option for gliobl...

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Bibliographic Details
Main Authors: Fumiko Hagiwara, Daiki Omata, Lisa Munakata, Saori Kageyama, Kazuo Maruyama, Nobuki Kudo, Ryo Suzuki
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Pharmaceuticals
Subjects:
blood–brain barrier
microbubble
ultrasound
drug delivery system
cisplatin
glioblastoma
Online Access:https://www.mdpi.com/1424-8247/16/11/1599

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