Harnessing Autophagy to Overcome Antigen-Specific T-Cell Dysfunction: Implication for People Living with HIV-1

Harnessing Autophagy to Overcome Antigen-Specific T-Cell Dysfunction: Implication for People Living with HIV-1

Like other chronic viral infections, HIV-1 persistence inhibits the development of antigen-specific memory T-cells, resulting in the exhaustion of the immune response and chronic inflammation. Autophagy is a major lysosome-dependent mechanism of intracellular large-target degradation such as lipid a...

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Bibliographic Details
Main Authors: Nazanin Ghahari, Roman Telittchenko, Hamza Loucif, Stephane Isnard, Jean-Pierre Routy, David Olagnier, Julien van Grevenynghe
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:International Journal of Molecular Sciences
Subjects:
autophagy
Ag-specific T-cells
HIV-1
PLWH
EC
metabolism
Online Access:https://www.mdpi.com/1422-0067/24/13/11018

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