Tectorigenin: A Review of Its Sources, Pharmacology, Toxicity, and Pharmacokinetics
Tectorigenin is a well-known natural flavonoid aglycone and an active component that exists in numerous plants. Growing evidence suggests that tectorigenin has multiple pharmacological effects, such as anticancer, antidiabetic, hepatoprotective, anti-inflammatory, antioxidative, antimicrobial, cardi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/15/5904 |
| _version_ | 1797586263648239616 |
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| author | Juan Rong Fei Fu Chenxia Han Yaling Wu Qing Xia Dan Du |
| author_facet | Juan Rong Fei Fu Chenxia Han Yaling Wu Qing Xia Dan Du |
| author_sort | Juan Rong |
| collection | DOAJ |
| description | Tectorigenin is a well-known natural flavonoid aglycone and an active component that exists in numerous plants. Growing evidence suggests that tectorigenin has multiple pharmacological effects, such as anticancer, antidiabetic, hepatoprotective, anti-inflammatory, antioxidative, antimicrobial, cardioprotective, and neuroprotective. These pharmacological properties provide the basis for the treatment of many kinds of illnesses, including several types of cancer, diabetes, hepatic fibrosis, osteoarthritis, Alzheimer’s disease, etc. The purpose of this paper is to provide a comprehensive summary and review of the sources, extraction and synthesis, pharmacological effects, toxicity, pharmacokinetics, and delivery strategy aspects of tectorigenin. Tectorigenin may exert certain cytotoxicity, which is related to the administration time and concentration. Pharmacokinetic studies have demonstrated that the main metabolic pathways in rats for tectorigenin are glucuronidation, sulfation, demethylation and methoxylation, but that it exhibits poor bioavailability. From our perspective, further research on tectorigenin should cover: exploring the pharmacological targets and mechanisms of action; finding an appropriate concentration to balance pharmacological effects and toxicity; attempting diversified delivery strategies to improve the bioavailability; and structural modification to obtain tectorigenin derivatives with higher pharmacological activity. |
| first_indexed | 2024-03-11T00:20:52Z |
| format | Article |
| id | doaj.art-c65e342025d945c3835272aa8c77f0b6 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T00:20:52Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-c65e342025d945c3835272aa8c77f0b62023-11-18T23:20:24ZengMDPI AGMolecules1420-30492023-08-012815590410.3390/molecules28155904Tectorigenin: A Review of Its Sources, Pharmacology, Toxicity, and PharmacokineticsJuan Rong0Fei Fu1Chenxia Han2Yaling Wu3Qing Xia4Dan Du5West China Centre of Excellence for Pancreatitis, Institute of Integrated Traditional Chinese and Western Medicine, Sichuan Provincial Pancreatitis Centre and West China-Liverpool Biomedical Research Centre, West China Hospital, Sichuan University, Chengdu 610041, ChinaAdvanced Mass Spectrometry Center, Research Core Facility, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, ChinaWest China Centre of Excellence for Pancreatitis, Institute of Integrated Traditional Chinese and Western Medicine, Sichuan Provincial Pancreatitis Centre and West China-Liverpool Biomedical Research Centre, West China Hospital, Sichuan University, Chengdu 610041, ChinaAdvanced Mass Spectrometry Center, Research Core Facility, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, ChinaWest China Centre of Excellence for Pancreatitis, Institute of Integrated Traditional Chinese and Western Medicine, Sichuan Provincial Pancreatitis Centre and West China-Liverpool Biomedical Research Centre, West China Hospital, Sichuan University, Chengdu 610041, ChinaWest China Centre of Excellence for Pancreatitis, Institute of Integrated Traditional Chinese and Western Medicine, Sichuan Provincial Pancreatitis Centre and West China-Liverpool Biomedical Research Centre, West China Hospital, Sichuan University, Chengdu 610041, ChinaTectorigenin is a well-known natural flavonoid aglycone and an active component that exists in numerous plants. Growing evidence suggests that tectorigenin has multiple pharmacological effects, such as anticancer, antidiabetic, hepatoprotective, anti-inflammatory, antioxidative, antimicrobial, cardioprotective, and neuroprotective. These pharmacological properties provide the basis for the treatment of many kinds of illnesses, including several types of cancer, diabetes, hepatic fibrosis, osteoarthritis, Alzheimer’s disease, etc. The purpose of this paper is to provide a comprehensive summary and review of the sources, extraction and synthesis, pharmacological effects, toxicity, pharmacokinetics, and delivery strategy aspects of tectorigenin. Tectorigenin may exert certain cytotoxicity, which is related to the administration time and concentration. Pharmacokinetic studies have demonstrated that the main metabolic pathways in rats for tectorigenin are glucuronidation, sulfation, demethylation and methoxylation, but that it exhibits poor bioavailability. From our perspective, further research on tectorigenin should cover: exploring the pharmacological targets and mechanisms of action; finding an appropriate concentration to balance pharmacological effects and toxicity; attempting diversified delivery strategies to improve the bioavailability; and structural modification to obtain tectorigenin derivatives with higher pharmacological activity.https://www.mdpi.com/1420-3049/28/15/5904tectorigeninsourcesextraction and synthesispharmacologytoxicologypharmacokinetics |
| spellingShingle | Juan Rong Fei Fu Chenxia Han Yaling Wu Qing Xia Dan Du Tectorigenin: A Review of Its Sources, Pharmacology, Toxicity, and Pharmacokinetics Molecules tectorigenin sources extraction and synthesis pharmacology toxicology pharmacokinetics |
| title | Tectorigenin: A Review of Its Sources, Pharmacology, Toxicity, and Pharmacokinetics |
| title_full | Tectorigenin: A Review of Its Sources, Pharmacology, Toxicity, and Pharmacokinetics |
| title_fullStr | Tectorigenin: A Review of Its Sources, Pharmacology, Toxicity, and Pharmacokinetics |
| title_full_unstemmed | Tectorigenin: A Review of Its Sources, Pharmacology, Toxicity, and Pharmacokinetics |
| title_short | Tectorigenin: A Review of Its Sources, Pharmacology, Toxicity, and Pharmacokinetics |
| title_sort | tectorigenin a review of its sources pharmacology toxicity and pharmacokinetics |
| topic | tectorigenin sources extraction and synthesis pharmacology toxicology pharmacokinetics |
| url | https://www.mdpi.com/1420-3049/28/15/5904 |
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