Gradient light interference microscopy for 3D imaging of unlabeled specimens
Challenges in biological imaging include labeling, photobleaching and phototoxicity, as well as light scattering. Here, Nguyen et al. develop a quantitative phase method that uses low-coherence interferometry for label-free 3D imaging in scattering tissue.
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-00190-7 |
| _version_ | 1818851311204958208 |
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| author | Tan H. Nguyen Mikhail E. Kandel Marcello Rubessa Matthew B. Wheeler Gabriel Popescu |
| author_facet | Tan H. Nguyen Mikhail E. Kandel Marcello Rubessa Matthew B. Wheeler Gabriel Popescu |
| author_sort | Tan H. Nguyen |
| collection | DOAJ |
| description | Challenges in biological imaging include labeling, photobleaching and phototoxicity, as well as light scattering. Here, Nguyen et al. develop a quantitative phase method that uses low-coherence interferometry for label-free 3D imaging in scattering tissue. |
| first_indexed | 2024-12-19T07:03:00Z |
| format | Article |
| id | doaj.art-c65e37646af14d50945de891b9a135e7 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T07:03:00Z |
| publishDate | 2017-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-c65e37646af14d50945de891b9a135e72022-12-21T20:31:22ZengNature PortfolioNature Communications2041-17232017-08-01811910.1038/s41467-017-00190-7Gradient light interference microscopy for 3D imaging of unlabeled specimensTan H. Nguyen0Mikhail E. Kandel1Marcello Rubessa2Matthew B. Wheeler3Gabriel Popescu4Department of Electrical and Computer Engineering, University of Illinois at Urbana-ChampaignDepartment of Electrical and Computer Engineering, University of Illinois at Urbana-ChampaignCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-ChampaignCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-ChampaignDepartment of Electrical and Computer Engineering, University of Illinois at Urbana-ChampaignChallenges in biological imaging include labeling, photobleaching and phototoxicity, as well as light scattering. Here, Nguyen et al. develop a quantitative phase method that uses low-coherence interferometry for label-free 3D imaging in scattering tissue.https://doi.org/10.1038/s41467-017-00190-7 |
| spellingShingle | Tan H. Nguyen Mikhail E. Kandel Marcello Rubessa Matthew B. Wheeler Gabriel Popescu Gradient light interference microscopy for 3D imaging of unlabeled specimens Nature Communications |
| title | Gradient light interference microscopy for 3D imaging of unlabeled specimens |
| title_full | Gradient light interference microscopy for 3D imaging of unlabeled specimens |
| title_fullStr | Gradient light interference microscopy for 3D imaging of unlabeled specimens |
| title_full_unstemmed | Gradient light interference microscopy for 3D imaging of unlabeled specimens |
| title_short | Gradient light interference microscopy for 3D imaging of unlabeled specimens |
| title_sort | gradient light interference microscopy for 3d imaging of unlabeled specimens |
| url | https://doi.org/10.1038/s41467-017-00190-7 |
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