Roles of airway basal stem cells in lung homeostasis and regenerative medicine
Abstract Airway basal stem cells (BSCs) in the proximal airways are recognized as resident stem cells capable of self-renewing and differentiating to virtually every pseudostratified epithelium cell type under steady-state and after acute injury. In homeostasis, BSCs typically maintain a quiescent s...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-05-01
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| Series: | Respiratory Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12931-022-02042-5 |
| _version_ | 1811235431548715008 |
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| author | Meirong Wu Xiaojing Zhang Yijian Lin Yiming Zeng |
| author_facet | Meirong Wu Xiaojing Zhang Yijian Lin Yiming Zeng |
| author_sort | Meirong Wu |
| collection | DOAJ |
| description | Abstract Airway basal stem cells (BSCs) in the proximal airways are recognized as resident stem cells capable of self-renewing and differentiating to virtually every pseudostratified epithelium cell type under steady-state and after acute injury. In homeostasis, BSCs typically maintain a quiescent state. However, when exposed to acute injuries by either physical insults, chemical damage, or pathogen infection, the remaining BSCs increase their proliferation rate apace within the first 24 h and differentiate to restore lung homeostasis. Given the progenitor property of airway BSCs, it is attractive to research their biological characteristics and how they maintain homeostatic airway structure and respond to injury. In this review, we focus on the roles of BSCs in lung homeostasis and regeneration, detail the research progress in the characteristics of airway BSCs, the cellular and molecular signaling communications involved in BSCs-related airway repair and regeneration, and further discuss the in vitro models for airway BSC propagation and their applications in lung regenerative medicine therapy. |
| first_indexed | 2024-04-12T11:50:47Z |
| format | Article |
| id | doaj.art-c65f03c908344e9dbc228fad1f92d74b |
| institution | Directory Open Access Journal |
| issn | 1465-993X |
| language | English |
| last_indexed | 2024-04-12T11:50:47Z |
| publishDate | 2022-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Respiratory Research |
| spelling | doaj.art-c65f03c908344e9dbc228fad1f92d74b2022-12-22T03:34:10ZengBMCRespiratory Research1465-993X2022-05-0123111210.1186/s12931-022-02042-5Roles of airway basal stem cells in lung homeostasis and regenerative medicineMeirong Wu0Xiaojing Zhang1Yijian Lin2Yiming Zeng3Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Fujian Medical UniversityDepartment of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Fujian Medical UniversityDepartment of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Fujian Medical UniversityDepartment of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Fujian Medical UniversityAbstract Airway basal stem cells (BSCs) in the proximal airways are recognized as resident stem cells capable of self-renewing and differentiating to virtually every pseudostratified epithelium cell type under steady-state and after acute injury. In homeostasis, BSCs typically maintain a quiescent state. However, when exposed to acute injuries by either physical insults, chemical damage, or pathogen infection, the remaining BSCs increase their proliferation rate apace within the first 24 h and differentiate to restore lung homeostasis. Given the progenitor property of airway BSCs, it is attractive to research their biological characteristics and how they maintain homeostatic airway structure and respond to injury. In this review, we focus on the roles of BSCs in lung homeostasis and regeneration, detail the research progress in the characteristics of airway BSCs, the cellular and molecular signaling communications involved in BSCs-related airway repair and regeneration, and further discuss the in vitro models for airway BSC propagation and their applications in lung regenerative medicine therapy.https://doi.org/10.1186/s12931-022-02042-5Airway basal stem cellsLung regenerationHomeostasisSelf-renewDifferentiation |
| spellingShingle | Meirong Wu Xiaojing Zhang Yijian Lin Yiming Zeng Roles of airway basal stem cells in lung homeostasis and regenerative medicine Respiratory Research Airway basal stem cells Lung regeneration Homeostasis Self-renew Differentiation |
| title | Roles of airway basal stem cells in lung homeostasis and regenerative medicine |
| title_full | Roles of airway basal stem cells in lung homeostasis and regenerative medicine |
| title_fullStr | Roles of airway basal stem cells in lung homeostasis and regenerative medicine |
| title_full_unstemmed | Roles of airway basal stem cells in lung homeostasis and regenerative medicine |
| title_short | Roles of airway basal stem cells in lung homeostasis and regenerative medicine |
| title_sort | roles of airway basal stem cells in lung homeostasis and regenerative medicine |
| topic | Airway basal stem cells Lung regeneration Homeostasis Self-renew Differentiation |
| url | https://doi.org/10.1186/s12931-022-02042-5 |
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