A20 Establishes Negative Feedback With TRAF6/NF-κB and Attenuates Early Brain Injury After Experimental Subarachnoid Hemorrhage

A20 Establishes Negative Feedback With TRAF6/NF-κB and Attenuates Early Brain Injury After Experimental Subarachnoid Hemorrhage

Nuclear factor (NF)-κB–ty -50mediated neuroinflammation plays a crucial role in early brain injury (EBI) after subarachnoid hemorrhage (SAH). As an important negative feedback regulator of NF-κB, A20 is essential for inflammatory homeostasis. Herein, we tested the hypothesis that A20 attenuates EBI...

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Bibliographic Details
Main Authors: Hong-Ji Deng, QuZhen Deji, WangDui Zhaba, Jia-Qiang Liu, Sheng-Qing Gao, Yan-Ling Han, Meng-Liang Zhou, Chun-Xi Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Immunology
Subjects:
A20
TRAF6
NF-κB
subarachnoid hemorrhage
neuroinflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.623256/full

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