Epidemiologic characterization of human papillomavirus infection in rural Chaozhou, eastern Guangdong Province of China.
BACKGROUND: Human papilloma virus (HPV) infection was the main cause of cervical cancer. There were only a few reports and detailed data about epidemiological research of HPV infection in rural population of China. MATERIALS AND METHODS: The cervical cells of rural Chaozhou women were collected, and...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3286448?pdf=render |
| _version_ | 1818587282513330176 |
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| author | Qiang Chen Long-Xu Xie Zhi-Rong Qing Lie-Jun Li Zhao-Yun Luo Min Lin Shi-Ming Zhang Wen-Zhou Chen Bing-Zhong Lin Qi-Li Lin Hui Li Wei-Pian Chen Pei-Yao Zheng Ling-Zhi Mao Chan-Yu Chen Chun Yang Yong-Zhong Zhan Xiang-Zhi Liu Jia-Kun Zheng Li-Ye Yang |
| author_facet | Qiang Chen Long-Xu Xie Zhi-Rong Qing Lie-Jun Li Zhao-Yun Luo Min Lin Shi-Ming Zhang Wen-Zhou Chen Bing-Zhong Lin Qi-Li Lin Hui Li Wei-Pian Chen Pei-Yao Zheng Ling-Zhi Mao Chan-Yu Chen Chun Yang Yong-Zhong Zhan Xiang-Zhi Liu Jia-Kun Zheng Li-Ye Yang |
| author_sort | Qiang Chen |
| collection | DOAJ |
| description | BACKGROUND: Human papilloma virus (HPV) infection was the main cause of cervical cancer. There were only a few reports and detailed data about epidemiological research of HPV infection in rural population of China. MATERIALS AND METHODS: The cervical cells of rural Chaozhou women were collected, and multiplex real time PCR was firstly performed to detect high-risk HPV (HR-HPV) infection, which could detect 13 types of HR-HPV (types 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, and 68). Then, HPV-positive samples were typed by HPV GenoArray test. RESULTS: HR-HPV DNA was detected by multiplex real time-PCR in 3830 of 48559 cases (7.89%). There was a peak incidence in age of 55-60 years group, and a lower incidence in who lived in plain group compared with suburban, mountain and seashore group. 3380 cases of HPV positive sample were genotyped, 11.01% (372/3380) cases could not be classified, among the typed 3008 cases, 101 cases were identified without HR-HPV type infection, 2907 cases were infected with one HR-HPV type at least, the 6 most common HR-HPV types in descending order of infection, were type 52 (33.4%, 16 (20.95%), 58 (15.93%), 33 (9.94%), 68 (9.22%) and 18 (8.36%). The combined prevalence of HPV types 16 and 18 accounted for 28.52% of total infection. However, type 52 plus 58 presented 48.23% of total infection. 2209/2907 cases were infected with a single HPV type and 698/2907 cases were infected with multiple types, and multiple infection constituent ratio increased with age, with a peak incidence in age 55-60 years group. CONCLUSIONS: Our findings showed low prevalence of HPV vaccine types (16 and 18) and relatively high prevalence of HPV-52 and -58, support the hypothesis that the second-generation HPV vaccines including HPV-52 and -58 may offer higher protection for women in rural Guangdong Province. |
| first_indexed | 2024-12-16T09:06:23Z |
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| id | doaj.art-c65fadcbf002403ebf88a7ed5e2c4cae |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-16T09:06:23Z |
| publishDate | 2012-01-01 |
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| spelling | doaj.art-c65fadcbf002403ebf88a7ed5e2c4cae2022-12-21T22:37:03ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0172e3214910.1371/journal.pone.0032149Epidemiologic characterization of human papillomavirus infection in rural Chaozhou, eastern Guangdong Province of China.Qiang ChenLong-Xu XieZhi-Rong QingLie-Jun LiZhao-Yun LuoMin LinShi-Ming ZhangWen-Zhou ChenBing-Zhong LinQi-Li LinHui LiWei-Pian ChenPei-Yao ZhengLing-Zhi MaoChan-Yu ChenChun YangYong-Zhong ZhanXiang-Zhi LiuJia-Kun ZhengLi-Ye YangBACKGROUND: Human papilloma virus (HPV) infection was the main cause of cervical cancer. There were only a few reports and detailed data about epidemiological research of HPV infection in rural population of China. MATERIALS AND METHODS: The cervical cells of rural Chaozhou women were collected, and multiplex real time PCR was firstly performed to detect high-risk HPV (HR-HPV) infection, which could detect 13 types of HR-HPV (types 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, and 68). Then, HPV-positive samples were typed by HPV GenoArray test. RESULTS: HR-HPV DNA was detected by multiplex real time-PCR in 3830 of 48559 cases (7.89%). There was a peak incidence in age of 55-60 years group, and a lower incidence in who lived in plain group compared with suburban, mountain and seashore group. 3380 cases of HPV positive sample were genotyped, 11.01% (372/3380) cases could not be classified, among the typed 3008 cases, 101 cases were identified without HR-HPV type infection, 2907 cases were infected with one HR-HPV type at least, the 6 most common HR-HPV types in descending order of infection, were type 52 (33.4%, 16 (20.95%), 58 (15.93%), 33 (9.94%), 68 (9.22%) and 18 (8.36%). The combined prevalence of HPV types 16 and 18 accounted for 28.52% of total infection. However, type 52 plus 58 presented 48.23% of total infection. 2209/2907 cases were infected with a single HPV type and 698/2907 cases were infected with multiple types, and multiple infection constituent ratio increased with age, with a peak incidence in age 55-60 years group. CONCLUSIONS: Our findings showed low prevalence of HPV vaccine types (16 and 18) and relatively high prevalence of HPV-52 and -58, support the hypothesis that the second-generation HPV vaccines including HPV-52 and -58 may offer higher protection for women in rural Guangdong Province.http://europepmc.org/articles/PMC3286448?pdf=render |
| spellingShingle | Qiang Chen Long-Xu Xie Zhi-Rong Qing Lie-Jun Li Zhao-Yun Luo Min Lin Shi-Ming Zhang Wen-Zhou Chen Bing-Zhong Lin Qi-Li Lin Hui Li Wei-Pian Chen Pei-Yao Zheng Ling-Zhi Mao Chan-Yu Chen Chun Yang Yong-Zhong Zhan Xiang-Zhi Liu Jia-Kun Zheng Li-Ye Yang Epidemiologic characterization of human papillomavirus infection in rural Chaozhou, eastern Guangdong Province of China. PLoS ONE |
| title | Epidemiologic characterization of human papillomavirus infection in rural Chaozhou, eastern Guangdong Province of China. |
| title_full | Epidemiologic characterization of human papillomavirus infection in rural Chaozhou, eastern Guangdong Province of China. |
| title_fullStr | Epidemiologic characterization of human papillomavirus infection in rural Chaozhou, eastern Guangdong Province of China. |
| title_full_unstemmed | Epidemiologic characterization of human papillomavirus infection in rural Chaozhou, eastern Guangdong Province of China. |
| title_short | Epidemiologic characterization of human papillomavirus infection in rural Chaozhou, eastern Guangdong Province of China. |
| title_sort | epidemiologic characterization of human papillomavirus infection in rural chaozhou eastern guangdong province of china |
| url | http://europepmc.org/articles/PMC3286448?pdf=render |
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