Comparison of Pulmonary Artery Pressure before and after Kidney Transplantation in Kidney Transplant Patients with Pulmonary Hypertension
Background: Pulmonary hypertension (PH) is a common finding in chronic kidney disease (CKD) and is associated with increased mortality and morbidity. The effect of kidney transplantation on PH is not yet well evaluated. This study aimed to compare pulmonary artery pressure (PAP) before and after kid...
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| Format: | Article |
| Language: | English |
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Vesnu Publications
2022-11-01
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| Series: | ARYA Atherosclerosis |
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| Online Access: | https://arya.mui.ac.ir/article_17201_7400032ae9e1432bc855fc96959aba48.pdf |
| _version_ | 1828004086444720128 |
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| author | Sahar Ravanshad Anoush Azarfar Negin Jafarnezhad Sani Maryam Miri Yalda Ravanshad |
| author_facet | Sahar Ravanshad Anoush Azarfar Negin Jafarnezhad Sani Maryam Miri Yalda Ravanshad |
| author_sort | Sahar Ravanshad |
| collection | DOAJ |
| description | Background: Pulmonary hypertension (PH) is a common finding in chronic kidney disease (CKD) and is associated with increased mortality and morbidity. The effect of kidney transplantation on PH is not yet well evaluated. This study aimed to compare pulmonary artery pressure (PAP) before and after kidney transplantation in CKD patients.Methods: This longitudinal study was conducted on 33 CKD patients who were candidates for kidney transplantation in a tertiary hospital in Mashhad, Iran. Pulmonary artery pressure and ejection fraction (EF) were assessed using trans-thoracic echocardiography (TTE). Demographic and clinical findings, including age, gender, and body mass index (BMI), as well as laboratory assessments, including hemoglobin, serum calcium and phosphorus level, and parathyroid hormone, were recorded before transplantation. TTE assessment was repeated one year after transplantation. Results: Mean age of the study patients (17 males and 16 females) was 30.42 ± 9.71 years. The majority of patients (85%) received hemodialysis before transplantation. Compared to before transplantation, PAP significantly decreased (from 33.67 ± 6.78 to 26.06 ± 5.78 mmHg, p<0.001) and EF increased (from 52.85 ± 7.12 to 57.03 ± 4.08, p=0.003) one year after transplantation. A significant positive correlation was found between PAP difference and EF before transplantation.Conclusions: The findings of this study showed that kidney transplantation was correlated with improved PAP and EF one year after transplantation and EF before kidney transplantation was correlated with PAP changes. |
| first_indexed | 2024-04-10T07:08:47Z |
| format | Article |
| id | doaj.art-c662b3135f7843ca9910ec89dafe05d4 |
| institution | Directory Open Access Journal |
| issn | 1735-3955 2251-6638 |
| language | English |
| last_indexed | 2024-04-10T07:08:47Z |
| publishDate | 2022-11-01 |
| publisher | Vesnu Publications |
| record_format | Article |
| series | ARYA Atherosclerosis |
| spelling | doaj.art-c662b3135f7843ca9910ec89dafe05d42023-02-27T04:51:19ZengVesnu PublicationsARYA Atherosclerosis1735-39552251-66382022-11-0118November1610.48305/arya.2022.11802.245817201Comparison of Pulmonary Artery Pressure before and after Kidney Transplantation in Kidney Transplant Patients with Pulmonary HypertensionSahar Ravanshad0Anoush Azarfar1Negin Jafarnezhad Sani2Maryam Miri3Yalda Ravanshad4Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranKidney Transplantation Complications Research Center, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranKidney Transplantation Complications Research Center, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Community Medicine, Mashhad Branch, Islamic Azad University, Mashhad, IranBackground: Pulmonary hypertension (PH) is a common finding in chronic kidney disease (CKD) and is associated with increased mortality and morbidity. The effect of kidney transplantation on PH is not yet well evaluated. This study aimed to compare pulmonary artery pressure (PAP) before and after kidney transplantation in CKD patients.Methods: This longitudinal study was conducted on 33 CKD patients who were candidates for kidney transplantation in a tertiary hospital in Mashhad, Iran. Pulmonary artery pressure and ejection fraction (EF) were assessed using trans-thoracic echocardiography (TTE). Demographic and clinical findings, including age, gender, and body mass index (BMI), as well as laboratory assessments, including hemoglobin, serum calcium and phosphorus level, and parathyroid hormone, were recorded before transplantation. TTE assessment was repeated one year after transplantation. Results: Mean age of the study patients (17 males and 16 females) was 30.42 ± 9.71 years. The majority of patients (85%) received hemodialysis before transplantation. Compared to before transplantation, PAP significantly decreased (from 33.67 ± 6.78 to 26.06 ± 5.78 mmHg, p<0.001) and EF increased (from 52.85 ± 7.12 to 57.03 ± 4.08, p=0.003) one year after transplantation. A significant positive correlation was found between PAP difference and EF before transplantation.Conclusions: The findings of this study showed that kidney transplantation was correlated with improved PAP and EF one year after transplantation and EF before kidney transplantation was correlated with PAP changes.https://arya.mui.ac.ir/article_17201_7400032ae9e1432bc855fc96959aba48.pdfpulmonary hypertensionpulmonary artery pressurekidney transplantationchronic kidney failure |
| spellingShingle | Sahar Ravanshad Anoush Azarfar Negin Jafarnezhad Sani Maryam Miri Yalda Ravanshad Comparison of Pulmonary Artery Pressure before and after Kidney Transplantation in Kidney Transplant Patients with Pulmonary Hypertension ARYA Atherosclerosis pulmonary hypertension pulmonary artery pressure kidney transplantation chronic kidney failure |
| title | Comparison of Pulmonary Artery Pressure before and after Kidney Transplantation in Kidney Transplant Patients with Pulmonary Hypertension |
| title_full | Comparison of Pulmonary Artery Pressure before and after Kidney Transplantation in Kidney Transplant Patients with Pulmonary Hypertension |
| title_fullStr | Comparison of Pulmonary Artery Pressure before and after Kidney Transplantation in Kidney Transplant Patients with Pulmonary Hypertension |
| title_full_unstemmed | Comparison of Pulmonary Artery Pressure before and after Kidney Transplantation in Kidney Transplant Patients with Pulmonary Hypertension |
| title_short | Comparison of Pulmonary Artery Pressure before and after Kidney Transplantation in Kidney Transplant Patients with Pulmonary Hypertension |
| title_sort | comparison of pulmonary artery pressure before and after kidney transplantation in kidney transplant patients with pulmonary hypertension |
| topic | pulmonary hypertension pulmonary artery pressure kidney transplantation chronic kidney failure |
| url | https://arya.mui.ac.ir/article_17201_7400032ae9e1432bc855fc96959aba48.pdf |
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