Generation of human induced pluripotent stem cells (SDUKIi002-A) from a 22-year-old male diagnosed with autism spectrum disorder
Autism spectrum disorders are characterized by impaired social interaction and communication as well as restricted and repetitive interests and behavior. Increasing evidence points to an early-stage disruption of brain development. A human-induced pluripotent stem cell line (SDUKIi002-A) was created...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-07-01
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| Series: | Stem Cell Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1873506120301355 |
| _version_ | 1818276957459054592 |
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| author | Morad Kamand Mirolyuba Ilieva Sheena Louise Forsberg Mads Thomassen Åsa Fex Svenningsen Bjørn Holst Morten Meyer Tanja Maria Michel |
| author_facet | Morad Kamand Mirolyuba Ilieva Sheena Louise Forsberg Mads Thomassen Åsa Fex Svenningsen Bjørn Holst Morten Meyer Tanja Maria Michel |
| author_sort | Morad Kamand |
| collection | DOAJ |
| description | Autism spectrum disorders are characterized by impaired social interaction and communication as well as restricted and repetitive interests and behavior. Increasing evidence points to an early-stage disruption of brain development. A human-induced pluripotent stem cell line (SDUKIi002-A) was created from skin fibroblasts from a 22-year old autistic male identified in the “FYNEN-cohort” of Southern Denmark. Reprogramming of the fibroblasts was performed using integration-free episomal plasmids. Further characterization confirmed the expression of pluripotency markers, differentiation into the three germ layers, absence of chromosomal abnormalities, and mycoplasma infection. |
| first_indexed | 2024-12-12T22:53:54Z |
| format | Article |
| id | doaj.art-c662f9766e0b452595b4a3a0e2d39be7 |
| institution | Directory Open Access Journal |
| issn | 1873-5061 |
| language | English |
| last_indexed | 2024-12-12T22:53:54Z |
| publishDate | 2020-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Stem Cell Research |
| spelling | doaj.art-c662f9766e0b452595b4a3a0e2d39be72022-12-22T00:09:00ZengElsevierStem Cell Research1873-50612020-07-0146101834Generation of human induced pluripotent stem cells (SDUKIi002-A) from a 22-year-old male diagnosed with autism spectrum disorderMorad Kamand0Mirolyuba Ilieva1Sheena Louise Forsberg2Mads Thomassen3Åsa Fex Svenningsen4Bjørn Holst5Morten Meyer6Tanja Maria Michel7Institute of Clinical Research, Department of Psychiatry Research, University of Southern Denmark, Odense, Denmark; Institute of Molecular Medicine, Department of Neurobiology Research, University of Southern Denmark, Odense, Denmark; Psychiatry in the Region of Southern Denmark, Odense University Hospital, DenmarkInstitute of Clinical Research, Department of Psychiatry Research, University of Southern Denmark, Odense, Denmark; Psychiatry in the Region of Southern Denmark, Odense University Hospital, DenmarkInstitute of Clinical Research, Department of Psychiatry Research, University of Southern Denmark, Odense, Denmark; Psychiatry in the Region of Southern Denmark, Odense University Hospital, DenmarkInstitute of Clinical Research, Department of Human Genetics, Odense University Hospital, DenmarkInstitute of Molecular Medicine, Department of Neurobiology Research, University of Southern Denmark, Odense, Denmark; Brain Research – Inter Disciplinary Guided Excellence (BRIDGE), Odense, DenmarkBioneer A/S, Hørsholm, DenmarkInstitute of Molecular Medicine, Department of Neurobiology Research, University of Southern Denmark, Odense, Denmark; Brain Research – Inter Disciplinary Guided Excellence (BRIDGE), Odense, Denmark; Department of Neurology, Odense University Hospital, DenmarkInstitute of Clinical Research, Department of Psychiatry Research, University of Southern Denmark, Odense, Denmark; Brain Research – Inter Disciplinary Guided Excellence (BRIDGE), Odense, Denmark; Psychiatry in the Region of Southern Denmark, Odense University Hospital, Denmark; Corresponding author at: Institute of Clinical Research, Department of Psychiatry Research, University of Southern Denmark, Odense, Denmark.Autism spectrum disorders are characterized by impaired social interaction and communication as well as restricted and repetitive interests and behavior. Increasing evidence points to an early-stage disruption of brain development. A human-induced pluripotent stem cell line (SDUKIi002-A) was created from skin fibroblasts from a 22-year old autistic male identified in the “FYNEN-cohort” of Southern Denmark. Reprogramming of the fibroblasts was performed using integration-free episomal plasmids. Further characterization confirmed the expression of pluripotency markers, differentiation into the three germ layers, absence of chromosomal abnormalities, and mycoplasma infection.http://www.sciencedirect.com/science/article/pii/S1873506120301355 |
| spellingShingle | Morad Kamand Mirolyuba Ilieva Sheena Louise Forsberg Mads Thomassen Åsa Fex Svenningsen Bjørn Holst Morten Meyer Tanja Maria Michel Generation of human induced pluripotent stem cells (SDUKIi002-A) from a 22-year-old male diagnosed with autism spectrum disorder Stem Cell Research |
| title | Generation of human induced pluripotent stem cells (SDUKIi002-A) from a 22-year-old male diagnosed with autism spectrum disorder |
| title_full | Generation of human induced pluripotent stem cells (SDUKIi002-A) from a 22-year-old male diagnosed with autism spectrum disorder |
| title_fullStr | Generation of human induced pluripotent stem cells (SDUKIi002-A) from a 22-year-old male diagnosed with autism spectrum disorder |
| title_full_unstemmed | Generation of human induced pluripotent stem cells (SDUKIi002-A) from a 22-year-old male diagnosed with autism spectrum disorder |
| title_short | Generation of human induced pluripotent stem cells (SDUKIi002-A) from a 22-year-old male diagnosed with autism spectrum disorder |
| title_sort | generation of human induced pluripotent stem cells sdukii002 a from a 22 year old male diagnosed with autism spectrum disorder |
| url | http://www.sciencedirect.com/science/article/pii/S1873506120301355 |
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