Cell Attachment to Hydrogel-Electrospun Fiber Mat Composite Materials
Hydrogels, electrospun fiber mats (EFMs), and their composites have been extensively studied for tissue engineering because of their physical and chemical similarity to native biological systems. However, while chemically similar, hydrogels and electrospun fiber mats display very different topograph...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2012-07-01
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| Series: | Journal of Functional Biomaterials |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2079-4983/3/3/497 |
| _version_ | 1818007821650755584 |
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| author | Jessica O. Winter John J. Lannutti Ning Han Jed K. Johnson Kunal S. Parikh Patrick A. Bradley |
| author_facet | Jessica O. Winter John J. Lannutti Ning Han Jed K. Johnson Kunal S. Parikh Patrick A. Bradley |
| author_sort | Jessica O. Winter |
| collection | DOAJ |
| description | Hydrogels, electrospun fiber mats (EFMs), and their composites have been extensively studied for tissue engineering because of their physical and chemical similarity to native biological systems. However, while chemically similar, hydrogels and electrospun fiber mats display very different topographical features. Here, we examine the influence of surface topography and composition of hydrogels, EFMs, and hydrogel-EFM composites on cell behavior. Materials studied were composed of synthetic poly(ethylene glycol) (PEG) and poly(ethylene glycol)-poly(ε-caprolactone) (PEGPCL) hydrogels and electrospun poly(caprolactone) (PCL) and core/shell PCL/PEGPCL constituent materials. The number of adherent cells and cell circularity were most strongly influenced by the fibrous nature of materials (e.g., topography), whereas cell spreading was more strongly influenced by material composition (e.g., chemistry). These results suggest that cell attachment and proliferation to hydrogel-EFM composites can be tuned by varying these properties to provide important insights for the future design of such composite materials. |
| first_indexed | 2024-04-14T05:21:58Z |
| format | Article |
| id | doaj.art-c66367f718c6433086bae30804861bc0 |
| institution | Directory Open Access Journal |
| issn | 2079-4983 |
| language | English |
| last_indexed | 2024-04-14T05:21:58Z |
| publishDate | 2012-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj.art-c66367f718c6433086bae30804861bc02022-12-22T02:10:10ZengMDPI AGJournal of Functional Biomaterials2079-49832012-07-013349751310.3390/jfb3030497Cell Attachment to Hydrogel-Electrospun Fiber Mat Composite MaterialsJessica O. WinterJohn J. LannuttiNing HanJed K. JohnsonKunal S. ParikhPatrick A. BradleyHydrogels, electrospun fiber mats (EFMs), and their composites have been extensively studied for tissue engineering because of their physical and chemical similarity to native biological systems. However, while chemically similar, hydrogels and electrospun fiber mats display very different topographical features. Here, we examine the influence of surface topography and composition of hydrogels, EFMs, and hydrogel-EFM composites on cell behavior. Materials studied were composed of synthetic poly(ethylene glycol) (PEG) and poly(ethylene glycol)-poly(ε-caprolactone) (PEGPCL) hydrogels and electrospun poly(caprolactone) (PCL) and core/shell PCL/PEGPCL constituent materials. The number of adherent cells and cell circularity were most strongly influenced by the fibrous nature of materials (e.g., topography), whereas cell spreading was more strongly influenced by material composition (e.g., chemistry). These results suggest that cell attachment and proliferation to hydrogel-EFM composites can be tuned by varying these properties to provide important insights for the future design of such composite materials.http://www.mdpi.com/2079-4983/3/3/497hydrogelselectrospun fiberscell attachmentnanotopographycomposite materials |
| spellingShingle | Jessica O. Winter John J. Lannutti Ning Han Jed K. Johnson Kunal S. Parikh Patrick A. Bradley Cell Attachment to Hydrogel-Electrospun Fiber Mat Composite Materials Journal of Functional Biomaterials hydrogels electrospun fibers cell attachment nanotopography composite materials |
| title | Cell Attachment to Hydrogel-Electrospun Fiber Mat Composite Materials |
| title_full | Cell Attachment to Hydrogel-Electrospun Fiber Mat Composite Materials |
| title_fullStr | Cell Attachment to Hydrogel-Electrospun Fiber Mat Composite Materials |
| title_full_unstemmed | Cell Attachment to Hydrogel-Electrospun Fiber Mat Composite Materials |
| title_short | Cell Attachment to Hydrogel-Electrospun Fiber Mat Composite Materials |
| title_sort | cell attachment to hydrogel electrospun fiber mat composite materials |
| topic | hydrogels electrospun fibers cell attachment nanotopography composite materials |
| url | http://www.mdpi.com/2079-4983/3/3/497 |
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