Recent advances of γ-aminobutyric acid: Physiological and immunity function, enrichment, and metabolic pathway
γ-aminobutyric acid (GABA) is a non-protein amino acid which naturally and widely occurs in animals, plants, and microorganisms. As the chief inhibitory neurotransmitter in the central nervous system of mammals, it has become a popular dietary supplement and has promising application in food industr...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Nutrition |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.1076223/full |
| _version_ | 1797979557130665984 |
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| author | Zhou Heli Chen Hongyu Bao Dapeng Bao Dapeng Tan Yee Shin Zhong Yejun Zhang Xi Wu Yingying |
| author_facet | Zhou Heli Chen Hongyu Bao Dapeng Bao Dapeng Tan Yee Shin Zhong Yejun Zhang Xi Wu Yingying |
| author_sort | Zhou Heli |
| collection | DOAJ |
| description | γ-aminobutyric acid (GABA) is a non-protein amino acid which naturally and widely occurs in animals, plants, and microorganisms. As the chief inhibitory neurotransmitter in the central nervous system of mammals, it has become a popular dietary supplement and has promising application in food industry. The current article reviews the most recent literature regarding the physiological functions, preparation methods, enrichment methods, metabolic pathways, and applications of GABA. This review sheds light on developing GABA-enriched plant varieties and food products, and provides insights for efficient production of GABA through synthetic biology approaches. |
| first_indexed | 2024-04-11T05:40:32Z |
| format | Article |
| id | doaj.art-c66381aabe8f4fc79ef564e8993a7adb |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-11T05:40:32Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-c66381aabe8f4fc79ef564e8993a7adb2022-12-22T04:59:35ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-12-01910.3389/fnut.2022.10762231076223Recent advances of γ-aminobutyric acid: Physiological and immunity function, enrichment, and metabolic pathwayZhou Heli0Chen Hongyu1Bao Dapeng2Bao Dapeng3Tan Yee Shin4Zhong Yejun5Zhang Xi6Wu Yingying7School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, ChinaNational Engineering Research Center of Edible Fungi, Key Laboratory of Applied Mycological Resources and Utilization of Ministry of Agriculture, Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, Shanghai, ChinaSchool of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, ChinaNational Engineering Research Center of Edible Fungi, Key Laboratory of Applied Mycological Resources and Utilization of Ministry of Agriculture, Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, Shanghai, ChinaFaculty of Science and Mushroom Research Centre, Institute of Biological Sciences, University of Malaya, Kuala Lumpur, MalaysiaState Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, Jiangxi, ChinaBannerBio Nutraceuticals Inc., Shenzhen, ChinaNational Engineering Research Center of Edible Fungi, Key Laboratory of Applied Mycological Resources and Utilization of Ministry of Agriculture, Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, Shanghai, Chinaγ-aminobutyric acid (GABA) is a non-protein amino acid which naturally and widely occurs in animals, plants, and microorganisms. As the chief inhibitory neurotransmitter in the central nervous system of mammals, it has become a popular dietary supplement and has promising application in food industry. The current article reviews the most recent literature regarding the physiological functions, preparation methods, enrichment methods, metabolic pathways, and applications of GABA. This review sheds light on developing GABA-enriched plant varieties and food products, and provides insights for efficient production of GABA through synthetic biology approaches.https://www.frontiersin.org/articles/10.3389/fnut.2022.1076223/fullGABAenvironmental stressmicrobial fermentationneurotransmitteranabolismcatabolism |
| spellingShingle | Zhou Heli Chen Hongyu Bao Dapeng Bao Dapeng Tan Yee Shin Zhong Yejun Zhang Xi Wu Yingying Recent advances of γ-aminobutyric acid: Physiological and immunity function, enrichment, and metabolic pathway Frontiers in Nutrition GABA environmental stress microbial fermentation neurotransmitter anabolism catabolism |
| title | Recent advances of γ-aminobutyric acid: Physiological and immunity function, enrichment, and metabolic pathway |
| title_full | Recent advances of γ-aminobutyric acid: Physiological and immunity function, enrichment, and metabolic pathway |
| title_fullStr | Recent advances of γ-aminobutyric acid: Physiological and immunity function, enrichment, and metabolic pathway |
| title_full_unstemmed | Recent advances of γ-aminobutyric acid: Physiological and immunity function, enrichment, and metabolic pathway |
| title_short | Recent advances of γ-aminobutyric acid: Physiological and immunity function, enrichment, and metabolic pathway |
| title_sort | recent advances of γ aminobutyric acid physiological and immunity function enrichment and metabolic pathway |
| topic | GABA environmental stress microbial fermentation neurotransmitter anabolism catabolism |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.1076223/full |
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