PTPRD-inactivation-induced CXCL8 promotes angiogenesis and metastasis in gastric cancer and is inhibited by metformin

PTPRD-inactivation-induced CXCL8 promotes angiogenesis and metastasis in gastric cancer and is inhibited by metformin

Abstract Background Protein tyrosine phosphatase receptor delta (PTPRD) is frequently inactivated in various types of cancers. Here, we explored the underlying mechanism of PTPRD-loss-induced cancer metastasis and investigated an efficient treatment option for PTPRD-inactivated gastric cancers (GCs)...

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Bibliographic Details
Main Authors: Won Jung Bae, Ji Mi Ahn, Hye Eun Byeon, Seokwhi Kim, Dakeun Lee
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Angiogenesis
CXCL8
Gastric cancer
Metastasis
PTPRD
Online Access:https://doi.org/10.1186/s13046-019-1469-4

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