Soluble PD-L1 generated by endogenous retroelement exaptation is a receptor antagonist
Immune regulation is a finely balanced process of positive and negative signals. PD-L1 and its receptor PD-1 are critical regulators of autoimmune, antiviral and antitumoural T cell responses. Although the function of its predominant membrane-bound form is well established, the source and biological...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2019-11-01
|
Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/50256 |