Soluble PD-L1 generated by endogenous retroelement exaptation is a receptor antagonist

Soluble PD-L1 generated by endogenous retroelement exaptation is a receptor antagonist

Immune regulation is a finely balanced process of positive and negative signals. PD-L1 and its receptor PD-1 are critical regulators of autoimmune, antiviral and antitumoural T cell responses. Although the function of its predominant membrane-bound form is well established, the source and biological...

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Bibliographic Details
Main Authors: Kevin W Ng, Jan Attig, George R Young, Eleonora Ottina, Spyros I Papamichos, Ioannis Kotsianidis, George Kassiotis
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-11-01
Series:eLife
Subjects:
PD-L1
LINE
retroelement
receptor antagonist
Online Access:https://elifesciences.org/articles/50256

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