Evaluation of the ATN model in a longitudinal memory clinic sample with different underlying disorders
Abstract Introduction To evaluate the usefulness of the 2018 NIA‐AA (National Institute on Aging and Alzheimer's Association) research framework in a longitudinal memory clinic study with different clinical outcomes and underlying disorders. Methods We included 420 patients with mild cognitive...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/dad2.12031 |
| _version_ | 1797975547797569536 |
|---|---|
| author | C. Eckerström J. Svensson P. Kettunen M. Jonsson M. Eckerström |
| author_facet | C. Eckerström J. Svensson P. Kettunen M. Jonsson M. Eckerström |
| author_sort | C. Eckerström |
| collection | DOAJ |
| description | Abstract Introduction To evaluate the usefulness of the 2018 NIA‐AA (National Institute on Aging and Alzheimer's Association) research framework in a longitudinal memory clinic study with different clinical outcomes and underlying disorders. Methods We included 420 patients with mild cognitive impairment or subjective cognitive impairment. During the follow up, 27% of the patients converted to dementia, with the majority converting to Alzheimer's disease (AD) or mixed dementia. Based on the baseline values of the cerebrospinal fluid biomarkers, the patients were classified into one of the eight possible ATN groups (amyloid beta [Aβ] aggregation [A], tau aggregation reflecting neurofibrillary tangles [T], and neurodegeneration [N]). Results The majority of the patients converting to AD and mixed dementia were in ATN groups positive for A (71%). The A+T+N+ group was highly overrepresented among converters to AD and mixed dementia. Patients converting to dementias other than AD or mixed dementia were evenly distributed across the ATN groups Discussion Our findings provide support for the usefulness of the ATN system to detect incipient AD or mixed dementia. |
| first_indexed | 2024-04-11T04:37:17Z |
| format | Article |
| id | doaj.art-c66af62925c74274ba30887b234fdc10 |
| institution | Directory Open Access Journal |
| issn | 2352-8729 |
| language | English |
| last_indexed | 2024-04-11T04:37:17Z |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| spelling | doaj.art-c66af62925c74274ba30887b234fdc102022-12-28T09:12:13ZengWileyAlzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring2352-87292021-01-01131n/an/a10.1002/dad2.12031Evaluation of the ATN model in a longitudinal memory clinic sample with different underlying disordersC. Eckerström0J. Svensson1P. Kettunen2M. Jonsson3M. Eckerström4Department of Psychiatry and Neurochemistry Sahlgrenska Academy Institute of Neuroscience and Physiology University of Gothenburg SwedenDepartment of Internal Medicine, Institute of Medicine, Sahlgrenska Academy University of Gothenburg SwedenDepartment of Psychiatry and Neurochemistry Sahlgrenska Academy Institute of Neuroscience and Physiology University of Gothenburg SwedenDepartment of Psychiatry and Neurochemistry Sahlgrenska Academy Institute of Neuroscience and Physiology University of Gothenburg SwedenDepartment of Psychiatry and Neurochemistry Sahlgrenska Academy Institute of Neuroscience and Physiology University of Gothenburg SwedenAbstract Introduction To evaluate the usefulness of the 2018 NIA‐AA (National Institute on Aging and Alzheimer's Association) research framework in a longitudinal memory clinic study with different clinical outcomes and underlying disorders. Methods We included 420 patients with mild cognitive impairment or subjective cognitive impairment. During the follow up, 27% of the patients converted to dementia, with the majority converting to Alzheimer's disease (AD) or mixed dementia. Based on the baseline values of the cerebrospinal fluid biomarkers, the patients were classified into one of the eight possible ATN groups (amyloid beta [Aβ] aggregation [A], tau aggregation reflecting neurofibrillary tangles [T], and neurodegeneration [N]). Results The majority of the patients converting to AD and mixed dementia were in ATN groups positive for A (71%). The A+T+N+ group was highly overrepresented among converters to AD and mixed dementia. Patients converting to dementias other than AD or mixed dementia were evenly distributed across the ATN groups Discussion Our findings provide support for the usefulness of the ATN system to detect incipient AD or mixed dementia.https://doi.org/10.1002/dad2.12031Alzheimer's diseasecerebrospinal fluid biomarkersdementiadiagnosisfrontotemporal dementiaLewy body dementia |
| spellingShingle | C. Eckerström J. Svensson P. Kettunen M. Jonsson M. Eckerström Evaluation of the ATN model in a longitudinal memory clinic sample with different underlying disorders Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring Alzheimer's disease cerebrospinal fluid biomarkers dementia diagnosis frontotemporal dementia Lewy body dementia |
| title | Evaluation of the ATN model in a longitudinal memory clinic sample with different underlying disorders |
| title_full | Evaluation of the ATN model in a longitudinal memory clinic sample with different underlying disorders |
| title_fullStr | Evaluation of the ATN model in a longitudinal memory clinic sample with different underlying disorders |
| title_full_unstemmed | Evaluation of the ATN model in a longitudinal memory clinic sample with different underlying disorders |
| title_short | Evaluation of the ATN model in a longitudinal memory clinic sample with different underlying disorders |
| title_sort | evaluation of the atn model in a longitudinal memory clinic sample with different underlying disorders |
| topic | Alzheimer's disease cerebrospinal fluid biomarkers dementia diagnosis frontotemporal dementia Lewy body dementia |
| url | https://doi.org/10.1002/dad2.12031 |
| work_keys_str_mv | AT ceckerstrom evaluationoftheatnmodelinalongitudinalmemoryclinicsamplewithdifferentunderlyingdisorders AT jsvensson evaluationoftheatnmodelinalongitudinalmemoryclinicsamplewithdifferentunderlyingdisorders AT pkettunen evaluationoftheatnmodelinalongitudinalmemoryclinicsamplewithdifferentunderlyingdisorders AT mjonsson evaluationoftheatnmodelinalongitudinalmemoryclinicsamplewithdifferentunderlyingdisorders AT meckerstrom evaluationoftheatnmodelinalongitudinalmemoryclinicsamplewithdifferentunderlyingdisorders |