Applied physiologically‐based pharmacokinetic modeling to assess uridine diphosphate‐glucuronosyltransferase‐mediated drug–drug interactions for Vericiguat

Applied physiologically‐based pharmacokinetic modeling to assess uridine diphosphate‐glucuronosyltransferase‐mediated drug–drug interactions for Vericiguat

Abstract Vericiguat (Verquvo; US: Merck, other countries: Bayer) is a novel drug for the treatment of chronic heart failure. Preclinical studies have demonstrated that the primary route of metabolism for vericiguat is glucuronidation, mainly catalyzed by uridine diphosphate‐glucuronosyltransferase (...

Full description

Bibliographic Details
Main Authors:	Sebastian Frechen, Ibrahim Ince, André Dallmann, Michael Gerisch, Natalia A. Jungmann, Corina Becker, Maximilian Lobmeyer, Maria E. Trujillo, Shiyao Xu, Rolf Burghaus, Michaela Meyer
Format:	Article
Language:	English
Published:	Wiley 2024-01-01
Series:	CPT: Pharmacometrics & Systems Pharmacology
Online Access:	https://doi.org/10.1002/psp4.13059

Similar Items

Effects of Andrographis paniculata extract on uridine diphosphate-glucuronosyltransferase activity
by: Norzainah Ahmad, et al.
Published: (2005-01-01)

Influence of uridine diphosphate-glucuronosyltransferases (1A9) polymorphisms on mycophenolic acid pharmacokinetics in patients with renal transplant
by: H. S. Ciftci, et al.
Published: (2018-10-01)

Revisiting the Latency of Uridine Diphosphate-Glucuronosyltransferases (UGTs)—How Does the Endoplasmic Reticulum Membrane Influence Their Function?
by: Yuejian Liu, et al.
Published: (2017-08-01)

Effect of the genetic mutant G71R in uridine diphosphate-glucuronosyltransferase 1A1 on the conjugation of bilirubin
by: Chen Hong, et al.
Published: (2022-03-01)

Results from in vitro and in vivo studies evaluating the bioavailability, effects of food, and administration as crushed tablet suspension on vericiguat pharmacokinetics
by: Corina Becker, et al.
Published: (2022-11-01)

A generic framework for the physiologically‐based pharmacokinetic platform qualification of PK‐Sim and its application to predicting cytochrome P450 3A4–mediated drug–drug interactions
by: Sebastian Frechen, et al.
Published: (2021-06-01)

Bilirubin - Uridine Diphosphate Glucuronosyltransferase (Ugt1a1) Gene Mutations Among Newborn Babies In The Malay Population In Kelantan With Hyperbilirubinaemia
by: Yusoff, Surini
Published: (2005)

Homology Modeling of Human Uridine-5′-diphosphate-glucuronosyltransferase 1A6 Reveals Insights into Factors Influencing Substrate and Cosubstrate Binding
by: Alexander D. Smith, et al.
Published: (2020-03-01)

Properties of Dietary Flavone Glycosides, Aglycones, and Metabolites on the Catalysis of Human Endoplasmic Reticulum Uridine Diphosphate Glucuronosyltransferase 2B7 (UGT2B7)
by: Ting Xu, et al.
Published: (2023-11-01)

Physiologically‐based pharmacokinetic modeling to predict CYP3A4‐mediated drug‐drug interactions of finerenone
by: Thomas Wendl, et al.
Published: (2022-02-01)

Bilirubin-uridine diphosphate glucuronosyltransferase (UGT1A1) gene mutations among newborn babies in the Malay population in Kelantan with hyperbilirubinaemia [RJ276. S961 2005 f rb].
by: Yusoff, Surini
Published: (2005)

Glucosylation of (±)-Menthol by Uridine-Diphosphate-Sugar Dependent Glucosyltransferases from Plants
by: Elisabeth Kurze, et al.
Published: (2021-09-01)

Analysis of nucleotide variants in the promoter region of the uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) gene among neonatal jaundice Malay infants without variations in the exonic regions
by: Ismail, Rosliza
Published: (2015)

The Uridine diphosphate (UDP)-glycosyltransferases (UGTs) superfamily: the role in tumor cell metabolism
by: Wenyu Liu, et al.
Published: (2023-01-01)

The function of uridine diphosphate glucose pyrophosphorylase in the lyophilization-stress response of Lactobacillus acidophilus
by: Chaoran Xia, et al.
Published: (2022-06-01)

Regorafenib plus FOLFIRI with irinotecan dose escalated according to uridine diphosphate glucuronosyltransferase 1A1genotyping in previous treated metastatic colorectal cancer patients:study protocol for a randomized controlled trial
by: Cheng-Jen Ma, et al.
Published: (2019-12-01)

PBPK Modeling as a Tool for Predicting and Understanding Intestinal Metabolism of Uridine 5′-Diphospho-glucuronosyltransferase Substrates
by: Micaela B. Reddy, et al.
Published: (2021-08-01)

Uridine Diphosphate Promotes Rheumatoid Arthritis Through P2Y6 Activation
by: Hongxing Wang, et al.
Published: (2021-04-01)

Uridine Diphosphate Glucose (UDP-G) Activates Oxidative Stress and Respiratory Burst in Isolated Neutrophils
by: Fabiana Lairion, et al.
Published: (2023-10-01)

Mechanisms underlying the methylglyoxal-induced enhancement of uridine diphosphate-mediated contraction in rat femoral artery
by: Takayuki Matsumoto, et al.
Published: (2022-10-01)

Inhibitory Effects of Aschantin on Cytochrome P450 and Uridine 5′-diphospho-glucuronosyltransferase Enzyme Activities in Human Liver Microsomes
by: Soon-Sang Kwon, et al.
Published: (2016-04-01)

Genomic-Wide Identification and Characterization of the Uridine Diphosphate Glycosyltransferase Family in <i>Eucommia ulmoides</i> Oliver
by: Dan Ouyang, et al.
Published: (2021-09-01)

Ganglioside biosynthesis. Characterization of uridine diphosphate galactose: GM2 galactosyltransferase in Golgiapparatus from rat liver
by: F E Wilkinson, et al.
Published: (1976-03-01)

Deletion in the uridine diphosphate glucuronyltransferase 2B17 gene is associated with delayed pubarche in healthy boys
by: Annette Mouritsen, et al.
Published: (2018-03-01)

AM-2201 Inhibits Multiple Cytochrome P450 and Uridine 5′-Diphospho-Glucuronosyltransferase Enzyme Activities in Human Liver Microsomes
by: Ju-Hyun Kim, et al.
Published: (2017-03-01)

Cascade synthesis of uridine-5′-diphosphate glucuronic acid by coupling multiple whole cells expressing hyperthermophilic enzymes
by: Dan-Hua Meng, et al.
Published: (2019-07-01)

Metabolites Profiling of Melanoma Interstitial Fluids Reveals Uridine Diphosphate as Potent Immune Modulator Capable of Limiting Tumor Growth
by: Eleonora Vecchio, et al.
Published: (2021-09-01)

Mertansine Inhibits mRNA Expression and Enzyme Activities of Cytochrome P450s and Uridine 5′-Diphospho-Glucuronosyltransferases in Human Hepatocytes and Liver Microsomes
by: Won-Gu Choi, et al.
Published: (2020-03-01)

The Functionality of UDP-Glucuronosyltransferase Genetic Variants and their Association with Drug Responses and Human Diseases
by: Yazun Jarrar, et al.
Published: (2021-06-01)

Anti-cancer drugs elicit re-expression of UDP-glucuronosyltransferases in melanoma cells.
by: Ryan W Dellinger, et al.
Published: (2012-01-01)

Study of Bil-Uridine Diphosphate Glucuronyl Transferase (BILUDGPT- 1) Mutation in Neonatal Hyperbilirubinaemia with Glucose-6-Phosphate Dehydrogenase Deficiency.
by: Mohd Yusoff, Dr Narazah
Published: (2005)

ATP binding cassette transporters and uridine diphosphate glycosyltransferases are ancient protein families that evolved roles in herbicide resistance through exaptation
by: Samuel Caygill, et al.
Published: (2023-01-01)

ATP binding cassette transporters and uridine diphosphate glycosyltransferases are ancient protein families that evolved roles in herbicide resistance through exaptation.
by: Samuel Caygill, et al.
Published: (2023-01-01)

SsAGM1-Mediated Uridine Diphosphate-N-Acetylglucosamine Synthesis Is Essential for Development, Stress Response, and Pathogenicity of Sclerotinia sclerotiorum
by: Junting Zhang, et al.
Published: (2022-06-01)

Biosynthesis of rare 20(R)-protopanaxadiol/protopanaxatriol type ginsenosides through Escherichia coli engineered with uridine diphosphate glycosyltransferase genes
by: Lu Yu, et al.
Published: (2019-01-01)

YvcK, a protein required for cell wall integrity and optimal carbon source utilization, binds uridine diphosphate-sugars
by: Elodie Foulquier, et al.
Published: (2017-06-01)

Vericiguat: A New Hope for Heart Failure Patients
by: Raquel Chiles, et al.
Published: (2022-01-01)

Blood Pressure and Safety Events With Vericiguat in the VICTORIA Trial
by: Carolyn S. P. Lam, et al.
Published: (2021-11-01)

Victoria Trial: Vericiguat Joins the Big League, or does it?
by: Andrew J Stewart Coats
Published: (2020-01-01)

Vericiguat, a novel sGC stimulator: Mechanism of action, clinical, and translational science
by: Maria E. Trujillo, et al.
Published: (2023-12-01)