OCT4: A penetrant pluripotency inducer
Native OCT4 protein has the intrinsic ability of crossing cellular membranes to enter cells. This finding could revive efforts to induce pluripotency with proteins replacing nucleic acid-based approaches, and raises the intriguing question as to whether OCT4 can act non-cell-autonomously.
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2014-01-01
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| Series: | Cell Regeneration |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2045976917300202 |
| _version_ | 1818354384838328320 |
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| author | Xuecong Wang Ralf Jauch |
| author_facet | Xuecong Wang Ralf Jauch |
| author_sort | Xuecong Wang |
| collection | DOAJ |
| description | Native OCT4 protein has the intrinsic ability of crossing cellular membranes to enter cells. This finding could revive efforts to induce pluripotency with proteins replacing nucleic acid-based approaches, and raises the intriguing question as to whether OCT4 can act non-cell-autonomously. |
| first_indexed | 2024-12-13T19:24:34Z |
| format | Article |
| id | doaj.art-c66e73d2e362460688685fc56cc6e90b |
| institution | Directory Open Access Journal |
| issn | 2045-9769 |
| language | English |
| last_indexed | 2024-12-13T19:24:34Z |
| publishDate | 2014-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Cell Regeneration |
| spelling | doaj.art-c66e73d2e362460688685fc56cc6e90b2022-12-21T23:34:04ZengSpringerOpenCell Regeneration2045-97692014-01-013110.1186/2045-9769-3-6OCT4: A penetrant pluripotency inducerXuecong Wang0Ralf Jauch1Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences (GIBH), 190 Kai Yuan Avenue, Science Park, Guangzhou 510530, ChinaGuangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences (GIBH), 190 Kai Yuan Avenue, Science Park, Guangzhou 510530, ChinaNative OCT4 protein has the intrinsic ability of crossing cellular membranes to enter cells. This finding could revive efforts to induce pluripotency with proteins replacing nucleic acid-based approaches, and raises the intriguing question as to whether OCT4 can act non-cell-autonomously.http://www.sciencedirect.com/science/article/pii/S2045976917300202OCT4Cell penetrating peptideInduced pluripotent stem cellsReprogrammingPluripotency |
| spellingShingle | Xuecong Wang Ralf Jauch OCT4: A penetrant pluripotency inducer Cell Regeneration OCT4 Cell penetrating peptide Induced pluripotent stem cells Reprogramming Pluripotency |
| title | OCT4: A penetrant pluripotency inducer |
| title_full | OCT4: A penetrant pluripotency inducer |
| title_fullStr | OCT4: A penetrant pluripotency inducer |
| title_full_unstemmed | OCT4: A penetrant pluripotency inducer |
| title_short | OCT4: A penetrant pluripotency inducer |
| title_sort | oct4 a penetrant pluripotency inducer |
| topic | OCT4 Cell penetrating peptide Induced pluripotent stem cells Reprogramming Pluripotency |
| url | http://www.sciencedirect.com/science/article/pii/S2045976917300202 |
| work_keys_str_mv | AT xuecongwang oct4apenetrantpluripotencyinducer AT ralfjauch oct4apenetrantpluripotencyinducer |