Rhodanine scaffold: A review of antidiabetic potential and structure–activity relationships (SAR)
Diabetes is a chronic medical condition due to the lack of insulin or ineffective use of insulin. In recent years, diabetes has become one of the rapidly growing chronic diseases, and it has caused a burden on the individual and the economy. Rhodanine has been identified as an important scaffold in...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-09-01
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| Series: | Medicine in Drug Discovery |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590098622000124 |
| _version_ | 1798037068795871232 |
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| author | Ahmad Khairul Daniel bin Ahmad Kamar Lim Ju Yin Chin Tze Liang Gan Tjin Fung Vasudeva Rao Avupati |
| author_facet | Ahmad Khairul Daniel bin Ahmad Kamar Lim Ju Yin Chin Tze Liang Gan Tjin Fung Vasudeva Rao Avupati |
| author_sort | Ahmad Khairul Daniel bin Ahmad Kamar |
| collection | DOAJ |
| description | Diabetes is a chronic medical condition due to the lack of insulin or ineffective use of insulin. In recent years, diabetes has become one of the rapidly growing chronic diseases, and it has caused a burden on the individual and the economy. Rhodanine has been identified as an important scaffold in drug discovery because of its wide range of biological properties including antidiabetic. A number of studies have been reported regarding the activity of rhodanine-based compounds in the treatment of diabetes mellitus and its complications. This review aimed to explore the antidiabetic activity of rhodanine-based compounds and their structure–activity relationship (SAR) based on studies that have been reported. Our study discovered several studies about the compounds’ biological screening against a variety of targets, including aldose reductase, α-glucosidase, α-amylase, PPAR-γ and PTPT1B. Some compounds mentioned are also tested in vivo in living organisms. This review offers a resource for future antidiabetic drug development, as many of the hit compounds listed exhibited good antidiabetic properties. |
| first_indexed | 2024-04-11T21:21:09Z |
| format | Article |
| id | doaj.art-c670bba567754a6e8370bc2868119cec |
| institution | Directory Open Access Journal |
| issn | 2590-0986 |
| language | English |
| last_indexed | 2024-04-11T21:21:09Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Medicine in Drug Discovery |
| spelling | doaj.art-c670bba567754a6e8370bc2868119cec2022-12-22T04:02:37ZengElsevierMedicine in Drug Discovery2590-09862022-09-0115100131Rhodanine scaffold: A review of antidiabetic potential and structure–activity relationships (SAR)Ahmad Khairul Daniel bin Ahmad Kamar0Lim Ju Yin1Chin Tze Liang2Gan Tjin Fung3Vasudeva Rao Avupati4School of Pharmacy, International Medical University (IMU), Kuala Lumpur 57000, MalaysiaSchool of Pharmacy, International Medical University (IMU), Kuala Lumpur 57000, MalaysiaSchool of Pharmacy, International Medical University (IMU), Kuala Lumpur 57000, MalaysiaSchool of Pharmacy, International Medical University (IMU), Kuala Lumpur 57000, MalaysiaDepartment of Pharmaceutical Chemistry, School of Pharmacy, International Medical University (IMU), Kuala Lumpur 57000, Malaysia; Centre for Bioactive Molecules and Drug Delivery, Institute for Research, Development and Innovation (IRDI), International Medical University (IMU), Kuala Lumpur 57000, Malaysia; Corresponding author at: Department of Pharmaceutical Chemistry, E-Learning Lead, School of Pharmacy, International Medical University (IMU), Kuala Lumpur 57000, Malaysia.Diabetes is a chronic medical condition due to the lack of insulin or ineffective use of insulin. In recent years, diabetes has become one of the rapidly growing chronic diseases, and it has caused a burden on the individual and the economy. Rhodanine has been identified as an important scaffold in drug discovery because of its wide range of biological properties including antidiabetic. A number of studies have been reported regarding the activity of rhodanine-based compounds in the treatment of diabetes mellitus and its complications. This review aimed to explore the antidiabetic activity of rhodanine-based compounds and their structure–activity relationship (SAR) based on studies that have been reported. Our study discovered several studies about the compounds’ biological screening against a variety of targets, including aldose reductase, α-glucosidase, α-amylase, PPAR-γ and PTPT1B. Some compounds mentioned are also tested in vivo in living organisms. This review offers a resource for future antidiabetic drug development, as many of the hit compounds listed exhibited good antidiabetic properties.http://www.sciencedirect.com/science/article/pii/S2590098622000124Rhodanine2-Thioxo-4-thiazolidinoneDrug discoveryDiabetesAntidiabeticStructure–activity relationship (SAR) |
| spellingShingle | Ahmad Khairul Daniel bin Ahmad Kamar Lim Ju Yin Chin Tze Liang Gan Tjin Fung Vasudeva Rao Avupati Rhodanine scaffold: A review of antidiabetic potential and structure–activity relationships (SAR) Medicine in Drug Discovery Rhodanine 2-Thioxo-4-thiazolidinone Drug discovery Diabetes Antidiabetic Structure–activity relationship (SAR) |
| title | Rhodanine scaffold: A review of antidiabetic potential and structure–activity relationships (SAR) |
| title_full | Rhodanine scaffold: A review of antidiabetic potential and structure–activity relationships (SAR) |
| title_fullStr | Rhodanine scaffold: A review of antidiabetic potential and structure–activity relationships (SAR) |
| title_full_unstemmed | Rhodanine scaffold: A review of antidiabetic potential and structure–activity relationships (SAR) |
| title_short | Rhodanine scaffold: A review of antidiabetic potential and structure–activity relationships (SAR) |
| title_sort | rhodanine scaffold a review of antidiabetic potential and structure activity relationships sar |
| topic | Rhodanine 2-Thioxo-4-thiazolidinone Drug discovery Diabetes Antidiabetic Structure–activity relationship (SAR) |
| url | http://www.sciencedirect.com/science/article/pii/S2590098622000124 |
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