Cell-free RNA signatures predict Alzheimer’s disease

Cell-free RNA signatures predict Alzheimer’s disease

Summary: There is a need for affordable, scalable, and specific blood-based biomarkers for Alzheimer’s disease that can be applied to a population level. We have developed and validated disease-specific cell-free transcriptomic blood-based biomarkers composed by a scalable number of transcripts that...

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Bibliographic Details
Main Authors: Alejandro Cisterna-García, Aleksandra Beric, Muhammad Ali, Jose Adrian Pardo, Hsiang-Han Chen, Maria Victoria Fernandez, Joanne Norton, Jen Gentsch, Kristy Bergmann, John Budde, Joel S. Perlmutter, John C. Morris, Carlos Cruchaga, Juan A. Botia, Laura Ibanez
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:iScience
Subjects:
Clinical finding
Disease
Biochemistry
Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223026111
Description
Summary:Summary: There is a need for affordable, scalable, and specific blood-based biomarkers for Alzheimer’s disease that can be applied to a population level. We have developed and validated disease-specific cell-free transcriptomic blood-based biomarkers composed by a scalable number of transcripts that capture AD pathobiology even in the presymptomatic stages of the disease. Accuracies are in the range of the current CSF and plasma biomarkers, and specificities are high against other neurodegenerative diseases.
ISSN:2589-0042

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