The Secretome of Filarial Nematodes and Its Role in Host-Parasite Interactions and Pathogenicity in Onchocerciasis-Associated Epilepsy
Filarial nematodes secrete bioactive molecules which are of interest as potential mediators for manipulating host biology, as they are readily available at the host-parasite interface. The adult parasites can survive for years in the mammalian host, due to their successful modulation of the host imm...
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| Format: | Article |
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Frontiers Media S.A.
2021-04-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2021.662766/full |
| _version_ | 1818601020858564608 |
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| author | An Hotterbeekx An Hotterbeekx Jolien Perneel Jolien Perneel Melissa Krizia Vieri Melissa Krizia Vieri Robert Colebunders Samir Kumar-Singh |
| author_facet | An Hotterbeekx An Hotterbeekx Jolien Perneel Jolien Perneel Melissa Krizia Vieri Melissa Krizia Vieri Robert Colebunders Samir Kumar-Singh |
| author_sort | An Hotterbeekx |
| collection | DOAJ |
| description | Filarial nematodes secrete bioactive molecules which are of interest as potential mediators for manipulating host biology, as they are readily available at the host-parasite interface. The adult parasites can survive for years in the mammalian host, due to their successful modulation of the host immune system and most of these immunomodulatory strategies are based on soluble mediators excreted by the parasite. The secretome of filarial nematodes is a key player in both infection and pathology, making them an interesting target for further investigation. This review summarises the current knowledge regarding the components of the excretory-secretory products (ESPs) of filarial parasites and their bioactive functions in the human host. In addition, the pathogenic potential of the identified components, which are mostly proteins, in the pathophysiology of onchocerciasis-associated epilepsy is discussed. |
| first_indexed | 2024-12-16T12:44:45Z |
| format | Article |
| id | doaj.art-c6748fd508564adb9905d9229ad97982 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-12-16T12:44:45Z |
| publishDate | 2021-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-c6748fd508564adb9905d9229ad979822022-12-21T22:31:19ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882021-04-011110.3389/fcimb.2021.662766662766The Secretome of Filarial Nematodes and Its Role in Host-Parasite Interactions and Pathogenicity in Onchocerciasis-Associated EpilepsyAn Hotterbeekx0An Hotterbeekx1Jolien Perneel2Jolien Perneel3Melissa Krizia Vieri4Melissa Krizia Vieri5Robert Colebunders6Samir Kumar-Singh7Molecular Pathology Group, Laboratory of Cell Biology and Histology, University of Antwerp, Antwerp, BelgiumGlobal Health Institute, University of Antwerp, Antwerp, BelgiumMolecular Pathology Group, Laboratory of Cell Biology and Histology, University of Antwerp, Antwerp, BelgiumGlobal Health Institute, University of Antwerp, Antwerp, BelgiumMolecular Pathology Group, Laboratory of Cell Biology and Histology, University of Antwerp, Antwerp, BelgiumGlobal Health Institute, University of Antwerp, Antwerp, BelgiumGlobal Health Institute, University of Antwerp, Antwerp, BelgiumMolecular Pathology Group, Laboratory of Cell Biology and Histology, University of Antwerp, Antwerp, BelgiumFilarial nematodes secrete bioactive molecules which are of interest as potential mediators for manipulating host biology, as they are readily available at the host-parasite interface. The adult parasites can survive for years in the mammalian host, due to their successful modulation of the host immune system and most of these immunomodulatory strategies are based on soluble mediators excreted by the parasite. The secretome of filarial nematodes is a key player in both infection and pathology, making them an interesting target for further investigation. This review summarises the current knowledge regarding the components of the excretory-secretory products (ESPs) of filarial parasites and their bioactive functions in the human host. In addition, the pathogenic potential of the identified components, which are mostly proteins, in the pathophysiology of onchocerciasis-associated epilepsy is discussed.https://www.frontiersin.org/articles/10.3389/fcimb.2021.662766/fullfilarial nematodesexcretory productsonchocerciasis-associated epilepsyhost-pathogen interactionimmune response |
| spellingShingle | An Hotterbeekx An Hotterbeekx Jolien Perneel Jolien Perneel Melissa Krizia Vieri Melissa Krizia Vieri Robert Colebunders Samir Kumar-Singh The Secretome of Filarial Nematodes and Its Role in Host-Parasite Interactions and Pathogenicity in Onchocerciasis-Associated Epilepsy Frontiers in Cellular and Infection Microbiology filarial nematodes excretory products onchocerciasis-associated epilepsy host-pathogen interaction immune response |
| title | The Secretome of Filarial Nematodes and Its Role in Host-Parasite Interactions and Pathogenicity in Onchocerciasis-Associated Epilepsy |
| title_full | The Secretome of Filarial Nematodes and Its Role in Host-Parasite Interactions and Pathogenicity in Onchocerciasis-Associated Epilepsy |
| title_fullStr | The Secretome of Filarial Nematodes and Its Role in Host-Parasite Interactions and Pathogenicity in Onchocerciasis-Associated Epilepsy |
| title_full_unstemmed | The Secretome of Filarial Nematodes and Its Role in Host-Parasite Interactions and Pathogenicity in Onchocerciasis-Associated Epilepsy |
| title_short | The Secretome of Filarial Nematodes and Its Role in Host-Parasite Interactions and Pathogenicity in Onchocerciasis-Associated Epilepsy |
| title_sort | secretome of filarial nematodes and its role in host parasite interactions and pathogenicity in onchocerciasis associated epilepsy |
| topic | filarial nematodes excretory products onchocerciasis-associated epilepsy host-pathogen interaction immune response |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2021.662766/full |
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