Intravenous pathogenicity of influenza virus A/H5N1/2014 isolated from pig in Ogbomoso, Nigeria
Understanding the pathogenicity of avian influenza viruses in poultry is an important scientific and public health challenge because of antigenic shift/drift and a source of novel, potentially human-pathogenic strains. We have previously isolated an influenza A strain (H5N1/2014/Ogbomoso) from an ou...
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| Format: | Article |
| Language: | English |
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Tripoli University
2018-09-01
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| Series: | Open Veterinary Journal |
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| Online Access: | https://www.openveterinaryjournal.com/OVJ-2017-11-206%20E.K.%20Oladipo%20et%20al.pdf |
| _version_ | 1819114080706756608 |
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| author | E. Kolawole Oladipo J. Kola Oloke J. Adekunle Adeniji |
| author_facet | E. Kolawole Oladipo J. Kola Oloke J. Adekunle Adeniji |
| author_sort | E. Kolawole Oladipo |
| collection | DOAJ |
| description | Understanding the pathogenicity of avian influenza viruses in poultry is an important scientific and public health challenge because of antigenic shift/drift and a source of novel, potentially human-pathogenic strains. We have previously isolated an influenza A strain (H5N1/2014/Ogbomoso) from an outbreak among pig and have now aimed to assess its pathogenicity in an avian host and to categorize it as a low or high pathogenic strain. Intravenous pathogenicity index of the isolated virus was assayed using experimental infection of 6 weeks old pathogen-specific free chicken. The peak of clinical signs was on day three post-infection, and one death was observed on day eight. The intravenous pathogenicity index of this isolate was 0.08. This results classify this isolate as a low pathogenic avian influenza strain. |
| first_indexed | 2024-12-22T04:39:37Z |
| format | Article |
| id | doaj.art-c674d8e96f4045dcbe11aaa873e7b28d |
| institution | Directory Open Access Journal |
| issn | 2218-6050 2218-6050 |
| language | English |
| last_indexed | 2024-12-22T04:39:37Z |
| publishDate | 2018-09-01 |
| publisher | Tripoli University |
| record_format | Article |
| series | Open Veterinary Journal |
| spelling | doaj.art-c674d8e96f4045dcbe11aaa873e7b28d2022-12-21T18:38:47ZengTripoli UniversityOpen Veterinary Journal2218-60502218-60502018-09-0183347350http://dx.doi.org/10.4314/ovj.v8i3.16Intravenous pathogenicity of influenza virus A/H5N1/2014 isolated from pig in Ogbomoso, NigeriaE. Kolawole Oladipo0J. Kola Oloke1J. Adekunle Adeniji2Department of Microbiology, Virus Research Laboratory, Adeleke University, P.M.B. 250, Ede, Osun State, Nigeria and Department of Pure and Applied Biology (Microbiology Unit), Ladoke Akintola University of Technology, P.M.B. 4000, Ogbomoso, Oyo State, NigeriaDepartment of Pure and Applied Biology (Microbiology Unit), Ladoke Akintola University of Technology, P.M.B. 4000, Ogbomoso, Oyo State, NigeriaVirology Department, College of Medicine, University of Ibadan, Ibadan, Oyo State, NigeriaUnderstanding the pathogenicity of avian influenza viruses in poultry is an important scientific and public health challenge because of antigenic shift/drift and a source of novel, potentially human-pathogenic strains. We have previously isolated an influenza A strain (H5N1/2014/Ogbomoso) from an outbreak among pig and have now aimed to assess its pathogenicity in an avian host and to categorize it as a low or high pathogenic strain. Intravenous pathogenicity index of the isolated virus was assayed using experimental infection of 6 weeks old pathogen-specific free chicken. The peak of clinical signs was on day three post-infection, and one death was observed on day eight. The intravenous pathogenicity index of this isolate was 0.08. This results classify this isolate as a low pathogenic avian influenza strain.https://www.openveterinaryjournal.com/OVJ-2017-11-206%20E.K.%20Oladipo%20et%20al.pdfH5N1InfluenzaIntravenous pathogenicityNigeriaOgbomoso |
| spellingShingle | E. Kolawole Oladipo J. Kola Oloke J. Adekunle Adeniji Intravenous pathogenicity of influenza virus A/H5N1/2014 isolated from pig in Ogbomoso, Nigeria Open Veterinary Journal H5N1 Influenza Intravenous pathogenicity Nigeria Ogbomoso |
| title | Intravenous pathogenicity of influenza virus A/H5N1/2014 isolated from pig in Ogbomoso, Nigeria |
| title_full | Intravenous pathogenicity of influenza virus A/H5N1/2014 isolated from pig in Ogbomoso, Nigeria |
| title_fullStr | Intravenous pathogenicity of influenza virus A/H5N1/2014 isolated from pig in Ogbomoso, Nigeria |
| title_full_unstemmed | Intravenous pathogenicity of influenza virus A/H5N1/2014 isolated from pig in Ogbomoso, Nigeria |
| title_short | Intravenous pathogenicity of influenza virus A/H5N1/2014 isolated from pig in Ogbomoso, Nigeria |
| title_sort | intravenous pathogenicity of influenza virus a h5n1 2014 isolated from pig in ogbomoso nigeria |
| topic | H5N1 Influenza Intravenous pathogenicity Nigeria Ogbomoso |
| url | https://www.openveterinaryjournal.com/OVJ-2017-11-206%20E.K.%20Oladipo%20et%20al.pdf |
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